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Very huge step forward for brain sensory mapping.


Data from functional magnetic resonance imaging (fMRI) have provided eye-popping pictures of the way the brain is wired, and allowed neuroscientists and laypeople alike to view intricate anatomical and functional connections between regions of the brain. But what if a new tool could be applied to MRI and other data, to listen to the way the brain works and how it is forged with connections?

An emerging effort to “sonify” imaging data is taking root at UT Dallas’ Center for Vital Longevity, in the lab of Dr. Gagan Wig. The approach, now funded by the Defense Advanced Research Projects Agency (DARPA), allows data to be represented by sounds from which a trained listener might be able to discern patterns of brain connectivity not readily seen in available visualization strategies.

Wig, an assistant professor in the School of Behavioral and Brain Sciences, is working with his UT Dallas colleagues Dr. Roger Malina, Arts and Technology Distinguished Chair, Scot Gresham-Lancaster, assistant professor in the sound design program in the School of Arts, Technology, and Emerging Communication, and a mix of scientists, computer programmers and artists to translate data to sight and sound.

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A rabbit’s brain has been successfully returned from long-term cryogenic storage, marking the first time a whole mammalian brain has been recovered in near-perfect condition.

It marks a significant breakthrough in the field of cryonics and boosts the prospect of one day bringing frozen human brains back to life.

Researchers from 21st Century Medicine (21CM) used a new technique called Aldehyde-stabilized cryopreservation that filled the vascular system of the rabbit brain with chemicals that would allow it to be cooled to −211 degrees Fahrenheit (−135 degrees Celsius). When it was thawed, the cell membranes, synapses, and intracellular structures remained intact.

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Researchers from 21st Century Medicine have developed a new technique to allow long term storage of a near-perfect mammalian brain. It’s a breakthrough that could have serious implications for cryonics, and the futuristic prospect of bringing the frozen dead back to life.

By using a chemical compound to turn a rabbit’s brain into a near glass-like state, and then cooling it to −211 degrees Fahrenheit (−135 degrees Celsius), a research team from California-based 21st Century Medicine (21CM) showed that it’s possible to enable near-perfect, long-term structural preservation of an intact mammalian brain. The achievement has earned not just accolades from the scientific community, but a prestigious award as well; the 21CM researchers are today being awarded the $26,735 Small Mammal Brain Preservation Prize, which is run by the Brain Preservation Foundation (BPF).

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The Brain Preservation Foundation (BPF) announced that the Small Mammal Brain Preservation Prize has officially been won. The spectacular result achieved by 21st Century Medicine researchers provides the first demonstration that near-perfect, long-term structural preservation of an intact mammalian brain is achievable.

A team from 21st Century Medicine, spearheaded by recent MIT graduate Robert McIntyre, has discovered a way to preserve the delicate neural circuits of an intact rabbit brain for very long-term storage using a combination of chemical fixation and cryogenic cooling. Proof of this accomplishment, and the full “Aldehyde-Stabilized Cryopreservation” (ASC) protocol, was recently published in the journal Cryobiology and has been independently verified by the BPF through extensive electron microscopic examination conducted by the two official judges of the prize: BPF President Ken Hayworth and Princeton neuroscience professor Sebastian Seung, author of “Connectome: How the Brain’s Wiring Makes Us Who We Are.”

“Every neuron and synapse looks beautifully preserved across the entire brain,” said Hayworth. “Simply amazing given that I held in my hand this very same brain when it was frozen solid… This is not your father’s cryonics.”

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Researchers at Sanford Burnham Prebys Medical Research Institute (SBP) have conclusively identified the protein complex that controls the genes needed to repair skeletal muscle. The discovery clears up deep-rooted conflicting data and will now help streamline efforts towards boosting stem cell-mediated muscle regeneration. Such strategies could treat muscle degenerative diseases such as muscular dystrophies, and those associated with aging and cancer.

The research, published today in eLife, describes the essential role of a TBP-containing TFIID-protein complex in activating genes that regenerate muscle tissue, and shows that an alternative protein called TBP2 is not involved in this task in adult muscles.

“Our discovery clarifies the identity of the ‘molecular switches’ that control the activation of muscle genes in (MuSCs),” said Barbora Malecova, Ph.D., postdoctoral fellow in the laboratory of Pier Lorenzo Puri, M.D., professor in the Development, Aging and Regeneration Program at SBP, and first author of the article. “Understanding what drives muscle gene expression gives us insights into molecular targets for regenerative medicine-based interventions (drugs) to treat muscle degenerative disorders.”

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HRP Area of Study: Environment | NASA

The Rise of the Rest and Mars Colonization
The Chinese word for crisis has two characters (危機). The first character represents danger and the second can be interpreted as opportunity, change of time, moment or chance. Even though the meaning of these Chinese characters can vary according to the context and nearby characters, the understanding of crisis (危機) as danger (危) plus opportunity (機) can help us think about the challenges faced by humanity in 2030.

In the coming years, China will have the largest economy of the planet, dethroning the USA to number two, both economically and scientifically. India will also be catching up fast as the third largest economy in the world, and its population will continue increasing after overtaking that of China in 2025. The re-emergence of Asia, as represented by China and India, will create a dramatic shift in power and geopolitics from what has been called the West to the East. The international hegemony enjoyed by the West during the last half millennium will move back to the East, which already led the world in many areas before the European Renaissance.

Fortunately, during the next two decades, the world economy will keep expanding and human conditions will get better throughout the whole planet. Indeed, a rising tide lifts all boats. Poverty will be substantially reduced and the environment will be significantly improved thanks to a growing global conscience and continuous advances in technology. Even Africa, the historic cradle of civilization, but considered a basket case during the last few centuries, will experience its own re-emergence in the world stage. After experiencing growth of 5% during the 2010s, and even higher during the 2020s, most African countries will be joining the rapid development of China and India, like most of the rest of the world.

The world in 2030 will be radically different from the world today. Rapid economic growth and convergence will have lifted the conditions of the bottom of the pyramid, and many people will raise their eyes into outer space. The colonization of Mars will start during the 2020s according to different plans by many governments (like those of China, Europe, India, Japan, Russia, and the USA) and even some private enterprises (for example, MarsOne, SpaceX, and Virgin Galactic).

Exponential Technologies and Immortality
Change is not constant, in fact, change is accelerating very fast. We will see more transformations in the next 20 years than in the past 200 years. Some technologies are radically changing humanity, in general, and also changing human beings, in particular. Many experts now talk about the four sciences and technologies of the future: NBIC (nano-bio-info-cogno). The NBIC fields are converging at an accelerating rate and they will help to transcend many human limitations in order to improve lives all around the world, and eventually beyond our tiny planet.

We might think of nano and bio as the hardware of life, and info and cogno as the software of life. In the next two decades, we will be able to replicate and improve the complexity of both the hardware and software of human beings. The complexity of our hardware is embodied in the human genome and its 3 gigabits of data, while the complexity of our software is implied by the human brain and its 1017 operations per second.

According to some technology trends, we might achieve physical immortality by copying, reproducing, augmenting, and enhancing our current hardware and software. In medicine, some scientists say that aging is actually a disease, but a curable disease. In fact, some cells do not age, for example, bacteria, germinal cells, stem cells, and cancer cells do not go through the aging process. It is fundamental to understand why this happens and use that knowledge to stop aging in more complex organisms like us. By so doing, our hardware might live indefinitely thanks to longevity discoveries related to genetic treatments, regenerative medicine, and stem cell therapies, for example.

We might also reach immortality through backing up our software. Thanks to research like the Human Brain Project in Europe and the BRAIN Initiative in the USA, we will be able to reengineer our brains. As computer-to-brain interfaces keep improving, some scientists believe that we will eventually be able to upload our brains into machines. In the next two decades, we might well see the “death of death”.

Humanity is fast approaching what some people call the “Singularity”: the moment when artificial intelligence will reach human intelligence levels, and then quickly overtake it. Perhaps then some humans might become transhumans and posthumans, changing forever life on Earth and the universe.

José Luis Cordeiro, MBA, PhD (www.cordeiro.org)

Visiting Research Fellow, IDE-JETRO, Tokyo, Japan (www.ide.go.jp)
Director, The Millennium Project, Venezuela Node (www.Millennium-Project.org)
Adjunct Professor, Moscow Institute of Physics and Technology, Russia (www.mipt.ru)
Founder and President Emeritus, World Future Society, Venezuela Chapter (www.FuturoVenezuela.net)
Founding Energy Advisor/Faculty, Singularity University, NASA Research Park, California, USA (www.SingularityU.org)