Lifeboat Foundation

As the brain ages, it becomes less efficient at recycling and eliminating build up of waste; ‘removal vans’ fail to do the rounds, and accumulation starts to overtake removal.

“We found that people in their 30s typically take about four hours to clear half the amyloid beta 42 from the brain,” says Randall J. Bateman. “In this new study, we show that at over 80 years old, it takes more than 10 hours.”

Research has uncovered that a protein called amyloid beta 42 (a natural byproduct of neural activity), is normally removed effectively in youth but the rate of clearance was found to slow progressively with age. Accumulation of amyloid beta 42 can lead to aggregation and consequent plaque formation and a slowdown in removal was tied to symptoms of dysfunction including memory loss and personality change. The study found that the brain disposes of this protein through a number of channels, and more work could uncover ways of boosting waste mangement in ailing brains, thus avoiding this toxic accumulation.

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My new Huff Post Op-Ed on the Immortality Bus and transhumanism: http://www.huffingtonpost.com/zoltan-istvan/why-a-presidenti…28826.html And if you haven’t donated something to the Indiegogo campaign for the bus, please consider doing so, as there’s only four days left and we’re currently short $9000. Anyone from any country can donate. Please also share the campaign. Thanks! https://www.indiegogo.com/projects/immortality-bus-with-pres…406#/story

On my tour called the “Immortality Bus,” I’m hoping to share with others that we should support a society and culture that is strongly pro-science and pro-longevity. My team and I plan to have embedded journalists aboard the bus, documenting our trip and enlivening the conversation.

Unfortunately, many people in America and around the world — especially those who believe in afterlives — are neutral or even oppose stopping biological death and aging with science. They feel it challenges what is natural in the human species. Transhumanists call these people “deathists,” those who believe and accept that death is a desirable fate.

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It can be all too easy to drift through life on automatic, forever putting things off, but statistics and data can give a physicality to things we barely notice or consider most of the time. These diagrams might just give you an entirely new perspective on your life.

Read the full article at The Longevity Reporter: http://www.longevityreporter.org/blog/2015/7/16/think-80-yea…hink-again.

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Peter Thiel, Larry Page, Sergey Brin, Bill Maris, Mark Zuckerberg…investment in biotech by leading figures in the world of technology is reaching new heights, with the regenerative medicine market projected to reach $20 billion by 2025 and the overall anti-aging market $345.8 billion by 2018.

These forecasts combined with a recent biotech boom mean that the economic reasons for investing are becoming clear and rising demand is virtually inevitable as the proportion of older individuals continues to grow to unparalleled levels. Bill Gates may have labelled anti-aging efforts as ‘egocentric’, but the investment doesn’t appear to be due to economic reasons alone; there is also a strong humanitarian and aspirational aspect that links some of these individuals together — the desire to utilise technology to create a better society.

‘With all being from a scientific background, Page, Brin and Maris particularly are clear in their belief that science holds the key to radically improving both the human condition and the world we live in — the pinnacle of this being radically prolonging human lifespan. In a recent Bloomberg interview Maris points out we live in an era where science can make all the tools available for any audacious vision out there…To these tech billionaires, evolution is meant to be transcended, and the resources put into organ regeneration, drugs that control ageing, or reprogramming DNA reflects their conviction that people have the right to lead better lives.’

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Misfolding proteins and aggregates are a serious problem for a cell; a great range of research has been able to link poor protein ‘quality control’ with a whole range of diseases, perhaps most famously Alzheimer’s disease. Recent work also suggests that the ‘heat shock’ response, a mechanism that protects against misfolding and corrects badly made proteins, may also become impaired with aging. This gradual deterioration could turn out to be one of the most significant drivers of both aging and age-related disease.

In research that support this theory, a recent paper provides evidence that the endoplasmic reticulum (ER), a cellular compartment which is responsible for creating and correctly forming protein structures, loses its oxidative power with age. This means that it loses the ability to form a type of bond called a disulphide bridge, a strong chemical bond which normally stabilises protein structures and holds them in particular shapes. The chemical environment within the ER was shown to change with age, disrupting the delicate equilibrium in the cell and leading to increased oxidative damage in other areas. Proteins moving through the ER on a production line often require disulphide linkages to mature correctly and stabilise their structure, but without this step they’re unable to do so and remain unstable.

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Once again telomeres are shown to be key players in aging.

The secret to living long, healthy lives and ageing beyond 100 has finally been cracked, according to a new study.

Scientists at Newcastle University say they have identified the key to longevity and good health amongst centenarians and how they pass that gift onto their offspring.

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“I am prepared to meet my Maker. Whether my Maker is prepared for the great ordeal of meeting me is another matter.” — Winston Churchill

Death still enjoys a steady paycheck, but being the Grim Reaper isn’t the cushy job that it used to be.

August 3, 2015 The question of why we age is one of the most fascinating questions for humankind, but nothing close to a satisfactory answer has been found to date. Scientists at the Leibniz-Institut für Molekulare Pharmakologie in Berlin have now shown, for the first time, that the ER loses its oxidative power in advanced age, which shifts the reducing/oxidising equilibrium — redox for short — in this compartment. This leads to a decline in the capacity to form the disulphide bridges that are so important for correct protein folding. As a consequence, many proteins can no longer mature properly and become unstable.

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Serendipity has as much a place in science as in love. That’s what Northeastern physicists Swastik Kar and Srinivas Sridhar found during their four-year project to modify graphene, a stronger-than-steel infinitesimally thin lattice of tightly packed carbon atoms. Primarily funded by the Army Research Laboratory and Defense Advanced Research Projects Agency, or DARPA, the researchers were charged with imbuing the decade-old material with thermal sensitivity for use in infrared imaging devices such as night-vision goggles for the military.

What they unearthed, published Friday in the journal Science Advances, was so much more: an entirely new material spun out of boron, nitrogen, carbon, and oxygen that shows evidence of magnetic, optical, and electrical properties as well as DARPA’s sought-after thermal ones. Its potential applications run the gamut: from 20-megapixel arrays for cellphone cameras to photo detectors to atomically thin transistors that when multiplied by the billions could fuel computers.

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