In order to slow aging, it’s important to know how circulating biomarkers change during aging, and how these biomarkers are associated with risk of death for all causes. In this video, I discuss blood test data for the oldest old, including centenarians (100 — 104y), semi-centenarians (105 — 109y), and super-centenarians (110y+).
Category: life extension – Page 471
Humans live much longer than chimps due to a slower epigenetic ‘clock’
Lil bits of info on DNA methylation, clocks.
Breakthrough advances in medicine and better nutrition have dramatically improved the longevity of the average human over the past two centuries. But that’s not to say that some couldn’t go on to live a long life even before the advent of modern medicine. As long as they were spared by disease, wars, and other risks that can bring an untimely death, humans could live to see their 70s, 80s, and even reach 100 years old as far back as ancient Rome.
The longevity of humans is somewhat exceptional among primates. Chimpanzees, our closest living relatives, rarely make it past age 50, despite them sharing over 99% of our DNA. In a new study, researchers think they’ve found our secret: chemical changes along our genome that occurred around 7–8 million years ago when our ancestors branched away from the lineage of chimps.
Slower ticker
There are tens of thousands of genes in the human genome, but that doesn’t mean all of them are active. For instance, through the methylation of DNA across certain sites of the genetic sequence, genes are locked in the “off” position. These modifications, known as epigenetic changes (‘epi’ means ‘above’ in Greek), do not alter the DNA sequence itself but, rather, simply regulate the activity of genes.
Diabetes Drug Metformin May Protect Aging Brains
WEDNESDAY, Sept. 23, 2020 (HealthDay News) — A common type 2 diabetes drug called metformin may have an unexpected, but positive, side effect: New research suggests that people taking the drug appear to have significantly slower declines in thinking and memory as they age.
“Our six-year study of older Australians with type 2 diabetes has uncovered a link between metformin use and slower cognitive [mental] decline and lower dementia rates,” said study author Dr. Katherine Samaras. She’s the leader of the healthy aging research theme at the Garvan Institute of Medical Research in New South Wales, Australia.
“The findings provide new hope for a means of reducing the risk of dementia in individuals with type 2 diabetes, and potentially those without diabetes,” Samaras said.
Targeting the Mechanisms of Aging Across Species
Targeting Mechanisms of Aging Across Species — I am joined on this episode of ideaXme by Dr. Matt Kaeberlein, Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences, University of Washington, to discuss his research focus on cross-species mechanisms of aging, in order to facilitate interventions that extend healthspan and improve quality of life — #Ideaxme #Health #Wellness #Longevity #Aging #LifeExtension #Rapamycin #MTor #CElegans #ExtracellularVesicles #Geroscience #GenomicInstability #AlzheimersDisease #Neurodegeneration #Parkinsons #MitochondrialDysfunction #OralHealth #SystemsBiology #DogAgingProject #Science #Transhumanism #Innovation #Immortality #IraPastor #Bioquark #Regenerage The Dog Aging Project.
Ira Pastor, idea me life sciences ambassador and founder of Bioquark, interviews Dr. Matt Kaeberlein, Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences at the University of Washington.
Dr. matt kaeberlein researchers aging across species:
Dr. Matt Kaeberlein, is Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences at the University of Washington. With a PhD from MIT in Biology, and post-doctoral work in the Department of Genome Sciences, University of Washington, his research interests are focused on basic mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life.
Dr. Kaeberlein has published nearly 200 papers in top scientific journals and has been recognized by several prestigious awards, including a Breakthroughs in Gerontology Award, an Alzheimer’s Association Young Investigator Award, an Ellison Medical Foundation New Scholar in Aging Award, a Murdock Trust Award, a Pioneer in Aging Award, and the Vincent Cristofalo Rising Star in Aging Research.
Boxer George “Monk” Foreman III talks of Compassion and Everybody Fights!
Boxing, Business, and Well-Being — I am joined on this episode of ideaXme by George Foreman III; entrepreneur, professional boxer, trainer, coach, son / business partner of former two-time heavyweight boxing champion George Foreman, and founder of EverybodyFights, a rapidly expanding chain of high-end, state-of-the-art boxing and fitness gyms — #Ideaxme #Health #Wellness #Boxing #GeorgeForeman #Fitness #Gyms #Nutrition #Longevity #Aging #Healthspan #Lifespan #LifeExtension #Business #Entrepreneurship #Innovation #Startup #IraPastor #Bioquark #Regenerage
Ira Pastor, ideaXme life sciences ambassador, interviews George “Monk” Foreman III; entrepreneur, professional boxer, trainer, coach, and Founder of Everybody Fights.
Ira Pastor Comments:
We’re honored to be joined by Mr. George “Monk” Foreman III; entrepreneur, professional boxer, trainer, coach, son of businessman and former two-time heavyweight boxing champion George Foreman, and founder of Everybody Fights, a rapidly expanding chain of high-end, state-of-the-art boxing and fitness gyms.
George “Monk” Foreman III:
David Sinclair talks about human rejuvenation (Excerpt with S/T in Spanish)
Short excerpt of a recent interview with Dr. David Sinclair published in the Youtube channel “Think Inc.”
Short excerpt of an interview with Dr. David Sinclair published in the Youtube channel “Think Inc.“
During the interview, Dr. Sinclair referres to the possibility of turning back the biological aging clock of the entire human body, through partial cellular reprograming in the not so distant future.
To watch the entire conversation clic here: https://youtu.be/QuBo2zMLZ8A
Aubrey de Grey’s Prediction for 2020
Aubrey de Grey, Chairman and Chief Science Officer of the Methuselah Foundation, presents a realistic scenario for 2020 in which everyone knows we will defeat the aging process.
Dr. Brian Kennedy — Preventive Medicine in an Aging Society
At our first online conference, Ending Age-Related Diseases 2020, Dr. Brian Kennedy of the National University of Singapore discussed the aging population of Singapore, the need for comprehensive healthcare, alpha-ketoglutarate and its effects against frailty in mice, ongoing trials of ketoglutarate in humans, spermidine against obesity, the role of biomarkers, and the importance of keeping people well rather than simply treating them when they are sick.
Ageing Can Be A Thing Of The Past
#aubreydegrey #ageing #ucaststudios #thetalkspot
The Talk Spot is an interview show where we have guests from all backgrounds on. This episode features returning guest Aubrey de Grey.
LAST EPISODE: https://www.youtube.com/watch?v=sXe5YPt_tbA&list=PL1-9Dd…-u&index=2
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