Lifeboat Foundation

At the Undoing Aging 2019 conference, we had the opportunity to interview Yuri Deigin, the CEO of Youthereum Genetics. His company is developing therapies that focus on OSKM, the Yamanaka factors known for turning cells back into a pluripotent state. By partially reprogramming cells using a single component of OSKM, Oct4, the company hopes to remove epigenetic aging from cells while still allowing them to retain their normal functions.

Do you think epigenetic alterations are a cause or a consequence of aging, and why?

Well, this question has so many different parts that need to be addressed. Of course, there are alterations that are consequences. Some of the epigenetics are consequences of aging, like epigenetic drift, with things that aren’t methylated in cells, as they divide throughout the lifetime, that methylation seems to get diluted away with subsequent divisions, but other parts of the genome, many of the epigenetic changes that happen that we can track throughout the aging of an organism are definitely not consequences of aging; they’re actually, from what I understand, causes of aging or causes in the change of metabolism and change of homeostasis, change how the organism behaves, essentially, that are driven by some high program in animal development, that basically silences some genes and activates other genes.

What other ramifications to follow? Your subjective quantum immortality coupled with soon-to-be discovered indefinite life extension at the civilizational level would spell out that YOU ARE ACTUALLY TO LIVE FOREVER! One can also see a viable resolution to the so-called ‘Mind-uploading’, or Star Trek ‘Teleporter dilemma’, questioning whether in those instances you create a copy of yourself but kill yourself in the process. By analogy to the previous deliberations, it follows that your consciousness has to “migrate” to your living self, thus making the case for successful consciousness transfer in both methods of disembodiments.

On this note, my friend, I’d like to conclude and profess that you are to live forever as an individuated evolving consciousness in this illusory Matrix-like universe where nothing is what it seems.

-by Alex Vikoulov, futurist, digital philosopher.

Continue reading “Quantum Immortality: Does Quantum Physics Imply You Are Immortal?” »

Loss of collagen protein depletes renewal cells that serve as skin’s fountain of youth.

• By Dana G. Smith on April 4, 2019

It is a crazy thought, right?! To think that mushrooms could be alien life. But before you dismiss the idea, take a look at some of principles of the theory. The main concept was formulated by the ingenious psychonaut philosopher Terrence McKenna, and goes along following lines.

Like no other form of life on our planet, the spores of mushrooms are almost perfectly suited to space travel. They can survive high vacuum and insanely low temperatures; the casing of a spore is one of the most electron dense materials in nature, to the point where McKenna says it is almost akin to a metal; global currents are even able to form on the quasi-metallic surface of an airborne spore, which then acts as a repellent to the extreme radiation of space. It is a mind boggling thought that something could evolve to be so perfectly suited to explore the universe.

Continue reading “Mushrooms Are A Highly Evolved Extraterrestrial Species — Organic Internet [VIDEO]” »

We recently attended the Undoing Aging Conference in Berlin and had the opportunity to interview Professor Vittorio Sebastiano of Turn. Bio, a company developing partial cellular reprogramming techniques to reverse cellular aging.

As we age, our cells experience changes to their epigenetic markers, and this, in turn, changes gene expression, which is proposed to be a primary reason we age. Recently, there has been considerable interest in resetting these epigenetic markers to reverse cellular aging; induced pluripotent stem cell (iPSC) creation uses similar techniques.

Continue reading “An Interview with Prof. Vittorio Sebastiano of Turn.Bio” »

Following is a transcript of the video.

The truth is, you’re going to die. We all are. That’s because unlike whooping cough or strep throat, death has no cure. But thanks to the latest medical breakthroughs we’re closer than ever to finding one. In fact, some experts predict that we’ll be able to live up to 20% longer over the next 100 years. That means children today might live until they’re 145 years old. And what about immortality? Well, even that’s not out of the question.

History is littered with unusual attempts to defy death. In 1920, for example, a Russian scientist thought he could prolong life by sewing a piece of monkey testicle to a human’s. And even more shockingly, the idea caught on. At least 300 people underwent the procedure. Ouch.

Continue reading “Experts predict that we’ll be able to live up to 20% longer over the next 100 years. Here’s how humans are trying to live forever” »

In this interview with Dr. Judith Campisi at Undoing Aging 2019, she talks about senolytics, immunotherapy, and other scientific topics.

At Undoing Aging 2019, we interviewed some of the best researchers who are involved in discovering therapies for the root causes of aging. Their research aims to ameliorate the damages of aging and may one day lead to a future without age-related diseases.

Continue reading “An Interview with Dr. Judith Campisi” »

With its pudgy body, tired eyes and hair loss, the lower mouse could easily be the father of the sprightly and alert animal nestling alongside.

But they are actually the same age, the result of extraordinary trials of drugs which are slowing down or even reversing the ageing process.

Scientists now believe that ageing itself is responsible for many major conditions such as Alzheimer’s, Parkinson’s, arthritis, cancer, heart disease, and diabetes. And they think they have found a way to turn it off.

Continue reading “Wonder drugs that target ‘zombie cells’ could reverse the ageing process and prevent diseases” »