Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: life extension – Page 389

A new vaccine that alters senescent cells in a way that pushes the immune system into removing them

Sorry if re-post…

A team of researchers affiliated with a large number of institutions in Japan has developed a vaccine that tricks the immune system into removing senescent cells. In their paper published in the journal Nature Aging, the group describes their vaccine, how it works and how effective it was when given to test mice.

Prior research has shown that part of the aging process is the development of —cells that outlive their usefulness but fail to die naturally. Instead, they produce chemicals that can lead to inflammation, aging and a host of other ailments. Prior research has shown that senescence occurs when cells stop dividing. Prior research has also shown that senescent cells can lead to in some instances and tumor suppression in others. Senescence also plays a role in tissue repair, and its impacts on the body vary depending on factors such as overall health and age. It is suspected that senescence is related to telomere erosion, and in some cases, environmental factors that lead to cell damage. In this new effort, the researchers have developed a vaccine that creates antibodies that attach to senescent cells, marking them for removal by .

The team was able to create the vaccine after identifying a protein made in senescent cells but not in healthy active cells. That allowed them to develop a type of vaccine based on the amino acids in the protein. When injected, the vaccine incites the body to produce antibodies that bind only to senescent cells, and that sets off an immune response that involves sending white blood cells to destroy the senescent cells.

AMA Live Stream #1

Yesterday’s longevity AMA: michael lustgarten, phd.

Questionsabout yesterday’s video, and more…AMA!

Join us on Patreon!
https://www.patreon.com/MichaelLustgartenPhD

Timestamps:
0:51 Evaluating what’s optimal for biomarkers that are genetically low or high.
3:59 Details on replicating the approach.
6:59 EVOO
9:41 Carotid artery thickness scan.
10:55 Exercise routine.
18:26 Sirtuins, resveratrol and longevity.
19:31 Using blood testing to identify which supplements are detrimental, neutral, or beneficial at n=1
23:00 Devices that I use.
24:54 TG/HDL ratio.
26:47 Use of herbs, adaptogens.
30:00 Rapamycin.
33:23 Fish oil.
35:30 Other fish besides sardines?
37:12 Balance between taste and health.
38:00 Tracking starch intake?
40:50 Current macros.
42:32 Importance of thymus and immunosenescence.
45:04 Evaluating what’s optimal for dietary vitamin/mineral intake.
47:46 Taking time off from supplements before blood testing (or not)
49:52 Thoughts on genetic biomarkers.
51:32 Adding weights to the biomarkers/Are they all equal for their effects during aging.
57:20 Cinnamon vs biomarkers.
58:50 Managing the diet/approach in social settings.
1:00:30 Oils and cooking.
1:01:45 Biomarker weights.
1:03:05 Investigating factors surrounding thymus hypertrophy.
1:04:08 Liposomal delivery and aging.
1:06:52 Finding trusted sources for supplements.
1:08:00 Attia, Rhonda.
1:10:18 Not just focusing on cardio for health.
1:11:05 ION test.
1:15:00 What if I don’t beat the longevity record.
1:16:30 Where would I bet on anti-aging tech.
1:18:45 Liver detox.
1:19:36 How often I eat junk food.
1:21:10 Metformin.
1:22:50 Sauna.
1:24:41 Blood donation: impact on biological age?
1:25:25 Is there an upper limit for venous recovery after blood testing?
1:26:15 No cheat days for Christmas?
1:27:29 Next-generation biological age clocks?
1:31:09 Parabiosis.
1:33:19 CR and lymphocytes.
1:36:27 Protein intake.
1:40:08 Cortisol and hormones.
1:42:00 Blood pressure.
1:43:44 TruAge clock.
1:47:35 Noise in epigenetic testing.

US tech investors believe they’re close to a cure for old age

Contrary to what you may think, getting old is not inevitable. And by getting old, I mean the bad parts: weakened muscles, fading memory, aching joints … or perhaps a disease such as cancer or diabetes makes an unwelcome appearance.

James Peyer, 35, is out to prove that age is, instead, like polio or tuberculosis. Those and other infectious diseases once were the biggest killers, until we developed effective vaccines or treatments.

Why, asked Peyer, co-founder of the New York longevity start-up Cambrian Biopharma, should age be any different? “Of our 100,000-year-plus history as a species, it’s been for only about 75 years that these diseases of ageing have been the primary predators of humankind.” He added: “We are rapidly zeroing in on our biggest.

Japanese scientists develop vaccine to eliminate cells behind aging

Senescent cells refer to those that have stopped dividing but do not die. They damage nearby healthy cells by releasing chemicals that cause inflammation.

The team identified a protein found in senescent cells in humans and mice and created a peptide vaccine based on an amino acid that constitutes the protein.

The vaccine enables the body to create antibodies that attach themselves to senescent cells, which are removed by white blood cells that adhere to the antibodies.

Kris Verburgh — CSO of Novos Labs views on Longevity Escape Velocity (con S/T en Español)

Clip during an interview made by Nicholas Singh, Senior Product Manager at Novos Labs to Kris Verburgh, CSO and Co-Founder of Novos Lab.

The clip shows the answer made by Kris Verburgh to a question made by José Cordeiro, PhD, MBA, Vice-Chairman of Humanity Plus, about the prediction made by Ray Kurzweil on the availability of full body human biological rejuvenation by 2045.

The episode took place during the webinar “Why Do We Age (And What Can We Do About It)?” organized by Novos Labs that took place on December 9, 2021.

To watch the entire webinar clic here: https://zoom.us/rec/play/lF-M5nVdYmXSiHQUAwC2YfrtaiUBfXUQP0N…pN068ViIHM

New FDA-approved eye drops could replace reading glasses for millions: “It’s definitely a life changer”

A newly approved eye drop hitting the market on Thursday could change the lives of millions of Americans with age-related blurred near vision, a condition affecting mostly people 40 and older.

Vuity, which was approved by the Food and Drug Administration in October, would potentially replace reading glasses for some of the 128 million Americans who have trouble seeing close-up. The new medicine takes effect in about 15 minutes, with one drop on each eye providing sharper vision for six to 10 hours, according to the company.

Toni Wright, one of the 750 participants in a clinical trial to test the drug, said she liked what she saw.

Hubble is Fully Operational Once Again

In the history of space exploration, a handful of missions have set new records for ruggedness and longevity. On Mars, the undisputed champion is the Opportunity rover, which was slated to run for 90 days but remained in operation for 15 years instead! In orbit around Mars, that honor goes to the 2001 Mars Odyssey, which is still operational 20 years after it arrived around the Red Planet.

In deep space, the title for the longest-running mission goes to the Voyager 1 probe, which has spent the past 44 years exploring the Solar System and what lies beyond. But in Earth orbit, the longevity prize goes to the Hubble Space Telescope (HST), which is once again fully operational after experiencing technical issues. With this latest restoration of operations, Hubble is well on its way to completing 32 years of service.

The issue began at 01:46 A.M. EDT (10:46 P.M. PDT) on October 23rd, when NASA reported that the venerated space telescope was sending error codes, which indicate the loss of a specific synchronization message. This message provides timing information that Hubble’s instruments use to respond to data requests and commands correctly. The same error codes were issued two days later, indicating multiple losses of synchronization messages and triggering Hubble to enter safe mode.

/* */