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Category: life extension – Page 303

Dr. Aubrey de Grey — Changing Priorities in Rejuvenation Technologies — Lifespan.io

Yes he starts with his personal controversy, emerging challenges, TAME, longevity is moving along well but has a long way to go.

Dr. Aubrey de Grey discusses the changing priorities at the forefront of the field of longevity rejuvenation research at Lifespan.io’s 2021 EARD conference. “The crusade is accelerating”, says Dr. De Grey, “but there’s so much still to do.”
De Grey is the author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging (2007). He is an international adjunct professor of the Moscow Institute of Physics and Technology, a fellow of the Gerontological Society of America, the American Aging Association, and the Institute for Ethics and Emerging Technologies.

SENS Research Foundation works to develop, promote, and ensure widespread access to therapies that cure and prevent the diseases and disabilities of aging by comprehensively repairing the damage that builds up in our bodies over time.

The annual Ending Age-Related Diseases (EARD) conference by Lifespan.io brings together longevity thought leaders together to exchange research reports, inspire and get inspired with new ideas, find collaborators, supporters, and mentors.

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A paradigm shift in aging research?

This is the video of Harold Katcher’s presentation to the London Futurists. It was a great discussion, be sure to check it out.

#haroldkatcher #antiaging #rejuvenation #futurism

It has been known for some time that young blood plasma can confer beneficial effects on various organs in mice, although the mechanisms and implications remained unclear. A recent breakthrough experiment is attracting more attention to this area of research: rats treated with a blood plasma mixture known as E5 subsequently had their effective biological age measured by epigenetic clocks, involving 593 tissue samples. The result was a halving of the epigenetic ages of blood, heart, and liver tissue, and a lesser reduction (still statistically significant) in the epigenetic age of the hypothalamus. This has been heralded as the single most dramatic age-reversal experiment in mammals to date.

On Saturday 18th September, the lead designer of these experiments, Dr Harold Katcher, joined London Futurists to present his analysis of the findings, his own distinctive theories of aging, and his expectation for future research and applications. He also answered questions about his new book, “The Illusion of Knowledge: The paradigm shift in aging research that shows the way to human rejuvenation”, which is available at https://www.amazon.co.uk/Illusion-Knowledge-paradigm-researc…09C7JNB64/

The event was introduced and moderated by David Wood, Chair of London Futurists.

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The microbial molecule that turns plants into zombies

A newly discovered manipulation mechanism used by parasitic bacteria to slow down plant aging, may offer new ways to protect disease-threatened food crops.

Parasites manipulate the organisms they live off to suit their needs, sometimes in drastic ways. When under the spell of a parasite, some plants undergo such extensive changes that they are described as “zombies”. They stop reproducing and serve only as a habitat and host for the parasitic pathogens.

Until now, there’s been little understanding of how this happens on a molecular and mechanistic level.

Who wants to live for ever? Jeff Bezos and Mark Zuckerberg do

What do you do when you’re so rich you could live to be a hundred and still not spend a noticeable fraction of your fortune? Buy yourself some more time. Literally.

The Amazon founder Jeff Bezos, 57 was reported last week to be among the backers of a new “rejuvenation company”, Altos Labs, a Silicon Valley start-up that has set its sights on understanding why we age and how we might prevent it — and ultimately work out how we might live for ever.

Bezos is not the only billionaire looking towards his end days. The men behind Google and Facebook are also dabbling in the dark art of manipulating mortality. But are they altruistically investing for the good of humanity — or is this.

Can Video Games Defeat Aging? World’s First Scientific Gaming Console: Demonpore 64

Hey it’s Han from WrySci HX talking about a really interesting concept — the world’s first biological gaming console that uses nanopore technology to detect molecules, and turn these readouts into games! It’s called the Demonpore 64! More below ↓↓↓

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Staying young, from the cells on up

Researchers at Université de Montréal and McGill University have discovered a new multi-enzyme complex that reprograms metabolism and overcomes “cellular senescence,” when aging cells stop dividing.

In their study published today in Molecular Cell, the researchers show that an named HTC (hydride transfer complex) can inhibit cells from aging.

“HTC protects cells from hypoxia, a lack of oxygen that normally leads to their death,” said senior author Gerardo Ferbeyre, an UdeM biochemistry professor and principal scientist at the CRCHUM, the university’s affiliated teaching hospital research center.

Fixing protein production errors lengthens lifespan

Reducing naturally occurring errors in protein synthesis (production) improves both health and lifespan, finds a new study in simple model organisms led by researchers at UCL and MRC London Institute of Medical Sciences.

The novel findings, published in Cell Metabolism, are the first to demonstrate a direct link between fewer mistakes and longevity.

Explaining the study, lead author Dr. Ivana Bjedov (UCL Cancer Institute), said: We commonly hear about DNA mutations, which can cause cancer, and are considered one of the underlying causes of ageing.

This Common Drug for Memory Loss May Also Help Restore Eye Sight

Citicoline, a drug that is naturally found in the body, is commonly used to treat a number of brain injuries and illnesses. For quite some time, doctors have prescribed it for strokes, vascular dementia, Parkinson’s disease, and general aging of the brain. Patients usually see improvement when taking the drug because the body uses it to create and repair cell membranes and lower the presence of free radicals, as noted in the Clinical Interventions in Aging Journal. (Free radicals, which are unstable molecules, can damage cells in the body and are associated with aging and illness.)

Now, researchers from the NYU Grossman School of Medicine have found evidence that citicoline can also be used to treat glaucoma. Normally, glaucoma is treated by removing fluid buildup in the eye, which creates pressure and wears down the cells in the eye and the nerves connecting to the brain. Though monitoring fluid buildup is important, glaucoma can still worsen after the pressure on the eye has been relieved.

Study Finds Evidence of Possible Link Between Herpes Simplex and Neurogenerative Diseases

Because the herpesvirus sits in neurons forever, there is speculation it is connected to neurodegenerative diseases. The immune system requires inflammation to constantly fight off the virus, and neurons have some degree of damage because of this continuous immune response, according to Dr. Tibor Valyi-Nagy, professor of pathology, director of neuropathology at UIC and research collaborator on the study.

Summary: Researchers discovered mutations of the OPTN gene resulted in increased herpesvirus 1 growth in the brains of mice, leading to the death of local neurons. This resulted in accelerated neurodegeneration. OPTN deficiency was also associated with impairments in immune response. While these findings are specific to the HSV-1 virus, researchers believe the findings may apply to up to eight herpesvirus infections.

Source: University of Illinois at Chicago

A new study by researchers at University of Illinois Chicago suggests that when the protein optineurin, or OPTN, is present in cells it restricts the spread of HSV-1, the herpes simplex virus type 1.

In a “first of its kind” study, researchers also found a potential direct connection between neurodegenerative diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), glaucoma, and the herpesvirus, said Dr. Deepak Shukla, the Marion H. Schenk Esq. Professor in Ophthalmology for Research of the Aging Eye, and vice chair for research at UIC.

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