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Category: life extension – Page 279

Hydraulic Instability Decides Who’s to Die and Who’s to Live

In many species including humans, the cells responsible for reproduction, the germ cells, are often highly interconnected and share their cytoplasm. In the hermaphrodite nematode Caenorhabditis elegans, up to 500 germ cells are connected to each other in the gonad, the tissue that produces eggs and sperm. These cells are arranged around a central cytoplasmic “corridor” and exchange cytoplasmic material fostering cell growth, and ultimately produce oocytes ready to be fertilized.

In past studies, researchers have found that C. elegans gonads generate more germ cells than needed and that only half of them grow to become oocytes, while the rest shrinks and die by physiological apoptosis, a programmed cell death that occurs in multicellular organisms. Now, scientists from the Biotechnology Center of the TU Dresden (BIOTEC), the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), the Cluster of Excellence Physics of Life (PoL) at the TU Dresden, the Max Planck Institute for the Physics of Complex Systems (MPI-PKS), the Flatiron Institute, NY, and the University of California, Berkeley, found evidence to answer the question of what triggers this cell fate decision between life and death in the germline.

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With 2700 locations across 10000 U.S. communities, YMCA is becoming a major hub for healthy living — From vaccinations and diabetes prevention programs, to healthy aging and wellness — Siva Balu, VP/Chief Information Officer — The Y of the U.S.A.

Mr. Siva Balu is Vice President and Chief Information Officer of YMCA of the U.S. (Y-USA), where he is working to rethink and reorganize the work of the organization’s information technology strategy to meet the changing needs of Y-USA and Ys throughout the country.

The YMCA is a leading nonprofit committed to strengthening community by connecting all people to their potential, purpose and each other, with a focus on empowering young people, improving health and well-being and inspiring action in and across communities, and with presence in 10000 neighborhoods across the nation, they have real ability to deliver positive change.

Mr. Balu has 20 years of healthcare technology experience in leadership roles for Blue Cross Blue Shield, the nation’s largest health insurer, which provides healthcare to over 107 million members—1 in 3 Americans. He most recently led the Enterprise Information Technology team at the Blue Cross Blue Shield Association (BCBSA), a national federation of Blue Cross and Blue Shield companies.

Mr. Balu was responsible for leading all aspects of IT, including architecture, application and product development, big data, business intelligence and data analytics, information security, project management, digital, infrastructure and operations. He has created several highly scalable innovative solutions that cater to the needs of members and patients throughout the country in all communities. He provided leadership in creating innovative solutions and adopting new technologies for national and international users.

Continue reading “Siva Balu — VP / Chief Information Officer — YMCA of the U.S.A. — People, Potential, & Purpose” | >

In many species including humans, the cells responsible for reproduction, the germ cells, are often highly interconnected and share their cytoplasm. In the hermaphrodite nematode Caenorhabditis elegans, up to 500 germ cells are connected to each other in the gonad, the tissue that produces eggs and sperm. These cells are arranged around a central cytoplasmic “corridor” and exchange cytoplasmic material fostering cell growth, and ultimately produce oocytes ready to be fertilized.

In past studies, researchers have found that C. elegans gonads generate more germ than needed and that only half of them grow to become oocytes, while the rest shrink and die by physiological apoptosis, a that occurs in multicellular organisms. Now, scientists from the Biotechnology Center of the TU Dresden (BIOTEC), the Max Planck Institute of molecular Cell Biology and Genetics (MPI-CBG), the Cluster of Excellence Physics of Life (PoL) at the TU Dresden, the Max Planck Institute for the Physics of Complex Systems (MPI-PKS), the Flatiron Institute, NY, and the University of California, Berkeley, have found evidence to answer the question of what triggers this cell fate decision between life and death in the germline.

Prior studies revealed the genetic basis and biochemical signals that drive physiological cell death, but the mechanisms that select and initiate apoptosis in individual germ cells remained unclear. As germ cells mature along the gonad of the nematode, they first collectively grow in size and in volume homogenously. In the study just published in Nature Physics, the scientists show that this homogenous growth suddenly shifts to a heterogenous growth where some cells become bigger and some cells become smaller.

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TIL a preprint publication points to another commonality found in blue zones: their lack of birth records. Author Dr. Saul Justin Newman concludes, “the designated ‘blue zones’ of Sardinia, Okinawa, and Icaria corresponded to regions with low incomes, low literacy, high crime rate and short life expectancy relative to their national average. As such, relative poverty and short lifespan constitute unexpected predictors of centenarian and supercentenarian status, and support a primary role of fraud and error in generating remarkable human age records.”

Can the blue zone diet help with longevity? We investigate Dan Buettner’s claims about blue zones and the corresponding lifestyle.

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Papers referenced in the video:

FGF21 and Chronic Kidney Disease: https://www.sciencedirect.com/science/article/pii/S002604952100038X

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466591/

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21:
https://pubmed.ncbi.nlm.nih.gov/18585098/

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice:
https://pubmed.ncbi.nlm.nih.gov/32877690/

Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression:

Continue reading “High FGF21, Low Insulin And Glucose: A Pro-Longevity Strategy?” | >

In the myofiber-specific model, they found that adding the Yamanaka factors accelerated muscle regeneration in mice by reducing the levels of a protein called Wnt4 in the niche, which in turn activated the satellite cells.

Salk research reveals clues about molecular changes underlying muscle loss tied to aging.

One of the many effects of aging is loss of muscle mass, which contributes to disability in older people. To counter this loss, scientists at the Salk Institute are studying ways to accelerate the regeneration of muscle tissue, using a combination of molecular compounds that are commonly used in stem-cell research.

In a study published on May 25, 2021, in Nature Communications, the investigators showed that using these compounds increased the regeneration of muscle cells in mice by activating the precursors of muscle cells, called myogenic progenitors. Although more work is needed before this approach can be applied in humans, the research provides insight into the underlying mechanisms related to muscle regeneration and growth and could one day help athletes as well as aging adults regenerate tissue more effectively.

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As part of preparing for an experiment aboard the International Space Station, researchers explored new ways to culture living heart cells for microgravity research. They found that cryopreservation, a process of storing cells at-80°C, makes it easier to transport these cells to the orbiting lab, providing more flexibility in launch and operations schedules. The process could benefit other biological research in space and on Earth.

The investigation, MVP Cell-03, cultured heart precursor on the station to study how microgravity affects the number of cells produced and how many of them survive. These precursor cells have potential for use in disease modeling, drug development, and , such as using cultured to replenish those damaged or lost due to cardiac disease.

Previous studies suggest that culturing such cells in simulated microgravity increases the efficiency of their production. But using live cell cultures in space presents some unique challenges. The MVP Cell-03 experiment, for example, must be conducted within a specific timeframe, when the cells are at just the right stage. Flight changes and crew availability could lead to delays that affect the research.

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Things to note: Treating the rats until they die. They are at 31 months and the longest they have lived without treatments is 38 months. Also, a small number of people have done this and though ailments like arthritis go away they still look elderly.

We recently had an update from Professor Rodolfo Goya who is conducting a follow up experiment from the one that Dr. Katcher first did in India, showing a rejuvenation in old rats. This video goes through the update that we had and provides a short introduction to the background.

Nicolas Chernavsky recently also did an interview with Didier Coeurnelle which discussed the update, which you can find here : https://youtu.be/GMNXjvXV268

Our earlier videos on the previous experiment and interview with Dr. Katcher are in this playlist https://www.youtube.com/playlist?list=PLkfzM7KJv6vaIQZ_n3WS6FHTpBtfS2lzw.

Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. It is the responsibility of you and your healthcare providers to make all decisions regarding your health. Products or services mentioned in this video are not a recommendation.

Continue reading “Young Blood Plasma Extending Rats Max Lifespan | Professor Rodolfo Goya’s Experiment Update” | >

It would be nice if they listed their diet.

Summary: Simple dietary changes and adopting lifestyle alterations, including improved sleep schedules, taking probiotics, and exercising, can reduce signs of biological aging by three years in just eight weeks, a new study reports.

Source: Impact Journals

A groundbreaking clinical trial shows we can reduce biological age (as measured by the Horvath 2013 DNAmAge clock) by more than three years in only eight weeks with diet and lifestyle through balancing DNA methylation.

A first-of-its-kind, peer-reviewed study provides scientific evidence that lifestyle and diet changes can deliver immediate and rapid reduction of our biological age. Since aging is the primary driver of chronic disease, this reduction has the power to help us live better, longer.

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More on thymus regeneration. Unless I understood wrong one patient’s epigenetic clock went from his mid 50’s to early 40’s.

Foresight Biotech & Health Extension Meeting sponsored by 100 Plus Capital.

2021 program & apply to join: https://foresight.org/biotech-health-extension-program/

Greg Fahy, Intervene Immune.
Thymus Rejuvenation Progress Update.

- Designed and led the TRIIM trial; Published the first report of thymus regeneration in a normal human; Granted patents on methods for and applications of human thymus regeneration.

Continue reading “Greg Fahy, Intervene Immune | Thymus Rejuvenation Progress Update” | >