Researchers at the Wake Forest Institute for Regenerative Medicine (WFIRM), North Carolina, are investigating the power of cells with regenerative effects. These researchers were the first to identify that stem cells in human urine have the potential for tissue regenerative effects, and are now continuing their investigation.
In a new study, the researchers have focused on how telomerase activity affects the regenerative potential of stem cells in human urine and other types of stem cells. The study was recently published in the journal Frontiers in Cell and Developmental Biology.
A landmark study that came out in 2005 showed that if you fused the blood systems of old and young mice, a process known as heterochronic parabiosis, it rejuvenated the cells of old mice. It suggested that there was something in the blood and there were two possible explanations; there were rejuvenating factors in the young blood, or there was dilution of pro-aging factors in the old blood. Or some combination of both.
Well, since 2005 more studies have come out. A 2016 study showed that heterochronic blood exchange, so just transfer from young to old, or old to young, without fusing, had a greater impact when old blood was given to young, than when young blood was given to old. In better words, “the inhibitory effects of old blood are more pronounced than the benefits of young”.
So, somewhat ruling out “factors in the young blood”. But even more support came from studies published a few years ago, where again they supported this latter theory. You see, simply diluting the old blood, that is taking plasma out of blood of the old mice and replacing it with saline and albumin (abundant protein found in blood) had the same effect. This process, known as neutral plasma exchange, involves no Frankenstein surgery or young blood vampire like scenario. AMAZING.
But, it still didn’t address why or how? The authors of that paper left us with this rather interesting hypothetical hypothesis graph of what potentially might be happening to some factors present in the blood, but they were otherwise unsure on what or how these beneficial effects were being achieved. What were the important factors to remove?
Paper referenced in the video: Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories. https://pubmed.ncbi.nlm.nih.gov/30197301/
You’ve likely heard the story by now: As the Sun grows old, it will swell up into a red giant. And as it expands, it will certainly swallow Mercury and Venus — and potentially Earth and even Mars — along the way.
This process, called planetary engulfment, is likely common across the galaxy, as aging stars eat up their own planets (and even companion stars or brown dwarfs). But astronomers still don’t understand exactly what happens to an unlucky planet that suddenly finds itself inside its parent star. Now, complex models called hydrodynamical simulations are shedding some light on the phenomenon, showing that factors such as a planet’s mass and the age of its star when it’s engulfed can have profound effects on what happens as the world is overtaken.
Transfusing young mice with blood from older rodents quickly triggers ageing, suggesting that cellular ageing isn’t just a case of wear and tear.
There is a longstanding hypothesis that surgically connecting an old mouse with a young rodent causes a transfer of blood that de-ages the older animal. While this benefits the older mouse, the effects on the young donor rodent were less clear.
To learn more, Irina Conboy at the University of California, Berkeley, and her colleagues transfused blood between young and old mice. Those aged 3 months got blood from animals that were approaching 2 years old.
https://www.timventura.com — Dr. Natasha Vita-More discusses transhumanism, human augmentation, life extension, and cryopreservation, and provides valuable insights into the latest medical advances empowering body augmentation & super-longevity in humans.
Our interview begins with a philosophical discussion of transhumanism, including what it is and why this emerging community is growing so rapidly — as it is driven forward by rapid advances in medical technology and an aging boomer population.
We also discuss the work of Dr. David Sinclair, Liz Parrish and Bioviva Sciences, Alcor, and a collection of notable authors, thinkers, and scientists pushing the boundaries of what it means to be human in the 21st century.
Dr. Natasha Vita-More is a pioneering leader and community organizer in transhumanism, and a proponent of human rights, morphological freedom, and ethical means for human enhancement.
𝙎𝙩𝙖𝙣𝙛𝙤𝙧𝙙 𝙣𝙚𝙪𝙧𝙤𝙨𝙘𝙞𝙚𝙣𝙩𝙞𝙨𝙩 𝙏𝙤𝙣𝙮 𝙒𝙮𝙨𝙨-𝘾𝙤𝙧𝙖𝙮, 𝙋𝙝𝘿, 𝙝𝙖𝙨 𝙨𝙥𝙚𝙣𝙩 20 𝙮𝙚𝙖𝙧𝙨 𝙙𝙞𝙨𝙘𝙤𝙫𝙚𝙧𝙞𝙣𝙜 𝙖𝙣𝙙 𝙞𝙣𝙫𝙚𝙨𝙩𝙞𝙜𝙖𝙩𝙞𝙣𝙜 𝙫𝙖𝙧𝙞𝙤𝙪𝙨 𝙢𝙤𝙡𝙚𝙘𝙪… See more.
Stanford neuroscientist Tony Wyss-Coray has spent 20 years unearthing and examining various molecules with neuroprotective and neurodegenerative properties.
Stanford neuroscientist Tony Wyss-Coray, PhD, has spent 20 years discovering and investigating various molecules with neuroprotective and neurodegenerative properties. These molecules are found in or on different cell types in the brain and on the blood vessels abutting it or floating in the blood and the cerebrospinal fluid that bathes it. As we age they become increasingly important.
Wyss-Coray and his colleagues have discovered substances in blood that can accelerate or slow down the brain-aging clock. They’ve identified proteins on blood-vessel surfaces through which some of these molecules can act on the brain, despite the existence of the blood-brain barrier. He’s even shown that older mice look and act younger after receiving young mouse cerebrospinal fluid.
