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Category: life extension – Page 195

28 to 34% lifespan increase in mice. I wonder if there would be side effects as a recent study showed Rapamycin and Metformin canceled each other’s side effects.

In a new study published in Aging Cell, researchers have tested several individual drugs and a combination of rapamycin plus acarbose as potential life extension agents in genetically heterogeneous mice [1].

Identification of successful anti-aging interventions is arguably one of the most challenging research problems to date. In addition to the complexity of aging, researchers have to deal with the biological heterogeneity of animals even within the same species and research reproducibility issues due to different experimental designs and approaches.

The National Institute on Aging Interventions Testing Program (ITP) was launched in 2004 with these limitations in mind. It is a peer-reviewed multi-institutional study evaluating potential lifespan-extending agents. The experiments are run in parallel at the Jackson Laboratory; the University of Michigan; and the University of Texas Health Science Center at San Antonio on genetically heterogeneous mice of both sexes.

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One of the hallmarks of aging, cellular senescence is what happens when aging cells do not die in the usual way (a process known as apoptosis) and start to accumulate in our bodies. The accumulation of these “senescent” cells is implicated in diseases including dementias, atherosclerosis, cancers, diabetes and arthritis. But senescence is not just part of the aging process – it tends to occur in individuals who develop frailty and multiple illnesses, and this can occur at any point during life.

In 2015, a team of researchers at the Mayo Clinic, led by Dr James L Kirkland, published a seminal paper in Aging Cell that introduced a new class of drugs called senolytics. Based on the idea that removing senescent cells may enhance human healthspan, these drugs were identified based on their ability to selectively target and eliminate those cells.

Longevity. Technology: Since the discovery of the first senolytics, hundreds of others have since been identified or created, and senotherapeutics is now one of the hottest areas in longevity, with a host of clinical trials under way and companies pursuing senolytic therapies for a range of age-related conditions. But what does the man who started it all think about the therapeutic field he helped create? In the first of two articles, we bring you Dr Kirkland’s unique perspective on the world of senolytics.

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This video is the 1st of a series of “What is Aging” webinars that aims to unravel what aging is, how we age, why we age, and how to reverse it.

We welcome Jason C. Mercurio, MFE, Dr. Jose Cordeiro, and Dr. Ian Hale to discuss the topic.

Thanks to our transhumanist influencers including:
@G. Stolyarov II @Ray Kurzweil 2017 @The Singularity is Near.
#ageless #agelesspartners #agereveal #longevity #biohacking #biotechnology #agingbackwards.

Book a coaching session with an Ageless Coach today:
https://agelesspartners.com/ageless-coaching/

Live long and age less!

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“The idea was to build a society like we have for all the other disciplines in medicine,” says Evelyne Bischof, a professor of medicine at Shanghai University of Medicine and Health Sciences and the inaugural vice president of the society. She has previously spearheaded educational efforts with Zhavoronkov and others, co-developing a formal course on longevity medicine for doctors. At the ARDD meeting, Bischof announced their course had just received continuing medical education (CME) accreditation from the American Medical Association.

“Longevity medicine is crystallizing as a discipline,” says Andrea Maier, an internal medicine specialist and geriatrician at National University of Singapore who is serving as the society’s inaugural president. One thing that’s not yet clear, several experts told me, is whether longevity will come to be established as a sub-discipline of geriatrics or internal medicine or whether it will become a separate medical specialty unto itself.

“Whichever way it goes,” Maier says, “it’s happening.”

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Building A Clinically Credible Platform For Longevity Medicine — Prof. Dr. Andrea Maier MD, PhD, National University of Singapore, Centre for Healthy Longevity.

Professor Dr. Andrea B. Maier, MD, Ph.D., is the Oon Chiew Seng Professor in Medicine, Healthy Ageing and Dementia Research, and Co-Director of the Centre for Healthy Longevity, at the National University Of Singapore (https://discovery.nus.edu.sg/19564-andrea-britta-maier).

Professor Maier also holds professorship appointments at VU University Medical Centre — https://research.vu.nl/en/persons/andrea-maier, Amsterdam, Netherlands, and University of Melbourne (https://findanexpert.unimelb.edu.au/profile/773728-andrea-maier), Australia, as well as is Director of Medicine and Community Care at the Royal Melbourne Hospital, Australia.

Professor Maier is also the President of the Australia and New Zealand Society for Sarcopenia and Frailty Research, as well as Founding President of the Healthy Longevity Medicine Society — https://hlms.co/.

A Fellow of the Royal Australasian College of Physicians (FRACP), Professor Maier graduated in Medicine (MD) 2003 from the University of Lübeck (Germany), was registered 2009 in The Netherlands as Specialist in Internal Medicine-Geriatrics and was appointed Full Professor of Gerontology at Vrije Universiteit Amsterdam (The Netherlands) in 2013 where she was the head of Geriatrics at the Vrije Universiteit Medical Center from 2012 to 2016.

Continue reading “Prof. Dr. Andrea B. Maier, MD, PhD — Building A Clinically Credible Platform For Longevity Medicine” | >

Just a matter of time for people.

Anti-Aging interview with David Sinclair by Mr. Myllet.

BY THE WAY…, I recently signed up for Dr. David Sinclair’s new test that will tell me how fast I’m aging — I thought you would want to know too!
You also can secure your free waiting list spot: https://otrim.ai/YourBiologicalAging.

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Free Video Series: Open Questions in AI and Neuroscience:

BI Workshop- Open Questions Ever

Show notes: https://braininspired.co/podcast/103/

Randal, Ken, and I discuss a host of topics around the future goal of uploading our minds into non-brain systems, to continue our mental lives and expand our range of experiences. The basic requirement for such a subtrate-independent mind is to implement whole brain emulation. We discuss two basic approaches to whole brain emulation. The “scan and copy” approach proposes we somehow scan the entire structure of our brains (at whatever scale is necessary) and store that scan until some future date when we have figured out how to us that information to build a substrate that can house your mind. The “gradual replacement” approach proposes we slowly replace parts of the brain with functioning alternative machines, eventually replacing the entire brain with non-biological material and yet retaining a functioning mind.
Randal and Ken are neuroscientists who understand the magnitude and challenges of a massive project like mind uploading, who also understand what we can do right now, with current technology, to advance toward that lofty goal, and who are thoughtful about what steps we need to take to enable further advancements.

Timestamps.
0:00 — Intro.
6:14 — What Ken wants.
11:22 — What Randal wants.
22:29 — Brain preservation.
27:18 — Aldehyde stabilized cryopreservation.
31:51 — Scan and copy vs. gradual replacement.
38:25 — Building a roadmap.
49:45 — Limits of current experimental paradigms.
53:51 — Our evolved brains.
1:06:58 — Counterarguments.
1:10:31 — Animal models for whole brain emulation.
1:15:01 — Understanding vs. emulating brains.
1:22:37 — Current challenges.

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Michael Levin is a biologist at Tufts University working on novel ways to understand and control complex pattern formation in biological systems. Please support this podcast by checking out our sponsors:
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Synthetic Organisms: https://tandfonline.com/doi/full/10.1080/19420889.2021.2005863
Limb Regeneration: https://science.org/doi/10.1126/sciadv.abj2164

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OUTLINE:
0:00 — Introduction.
1:40 — Embryogenesis.
9:08 — Xenobots: biological robots.
22:55 — Sense of self.
32:26 — Multi-scale competency architecture.
43:57 — Free will.
53:27 — Bioelectricity.
1:06:44 — Planaria.
1:18:33 — Building xenobots.
1:42:08 — Unconventional cognition.
2:06:39 — Origin of evolution.
2:13:41 — Synthetic organisms.
2:20:27 — Regenerative medicine.
2:24:13 — Cancer suppression.
2:28:15 — Viruses.
2:33:28 — Cognitive light cones.
2:38:03 — Advice for young people.
2:42:47 — Death.
2:52:17 — Meaning of life.

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