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Almost exactly one year ago, the Longevity Science Foundation emerged onto scene, announcing its bold ambition to work towards a goal of distributing upwards of $1 billion over the next ten years towards funding longevity research. Fast forward one year, and the foundation has announced its first calls for research funding applications: aging clocks and psychedelics in longevity and appointed non-profit fundraising expert Lisa Ireland as its president and CEO.

Longevity. Technology: It’s one thing to say you’re going to spend $1 billion on longevity and quite another to actually make it happen. With more than 25 years’ experience in executive leadership and fundraising roles at non-profit organisations including the United Way, Ireland has the kind of background needed to ensure the LSF delivers on its promise. We caught up with Ireland to learn more about her key objectives at the LSF, and her fresh perspective on the longevity field.

Ireland happily admits to having little knowledge of the longevity field before taking on the role at the LSF. Far from seeing it as a weakness, she views her lack of longevity experience as an advantage in a field that needs to expand its appeal beyond those who are already convinced of its importance.

A scientist shares what he’s learned about living longer, with the help of worms. Scientists are hard at work trying to understand what causes aging and how to help people stay healthy for longer. Biologist Matt Kaeberlein breaks down the science of longevity and tells us how he’s using a robot to test 100,000 aging drugs a year on microscopic worms and a long-term study on the aging of pet dogs. And we’ll leave the lab to visit Willie Mae Avery, the oldest person in Washington D.C., to hear what it’s like to live such a long life.

Portrait of 107-year-old Willie Mae Avery, D.C.‘s oldest living resident.
Credit: Photograph by Rebecca Hale, National Geographic.

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This video brought to you by BiOptimizers.

In this video Professor Sebastiano discusses the three most advanced interventions that Turn Bio is working on, for skin, immunology and muscles and when they will be available for human trial.

Professor Vittorio Sebastiano manages a lab in Stanford University which developed and patented technology for partial cellular reprogramming. He co-founded Turn Bio, where he is now Head of research, to translate this technology into clinical applications. And with that, let me start the interview.

Turn Bio website.
https://www.turn.bio/
Professor Sebastiano’s lab at Stanford.
https://med.stanford.edu/stemcell/institutefaculty/sebastiano.html.
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells.
https://pubmed.ncbi.nlm.nih.gov/32210226/

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The newly-created Longevity Escape Velocity Foundation (LEV) has released details of the first study in its flagship research programme: Robust Mouse Rejuvenation – Study 1.

Longevity. Technology: A highlight of Longevity Summit Dublin 2022 was Dr Aubrey de Grey’s announcement of his new foundation; LEV Foundation exists to proactively identify and address the most challenging obstacles on the path to the widespread availability of genuinely effective treatments to prevent and reverse human age-related disease, and to that end, its flagship research programme is a sequence of large mouse lifespan studies.

Mouse models are significant in aging research for several reasons. Mice and humans share many genetic and physiological similarities, including similar aging-related pathways, and this makes mice a useful model for studying the molecular and cellular processes underlying aging in humans.

We never stopped evolving.

Are humans still evolving? This question is a mystery for many, as about seven million years have passed since humans left the chimpanzee lineage. The factors that forced us to adapt, evolve, and survive harsh environments in the past are no longer relevant.

So does that mean we have stopped evolving?


CIPhotos/iStock.

Today, humans have much longer lifespans and advanced healthcare facilities at their disposal. We live in a comfortable and protected environment almost all the time. The external factors (also known as selection pressures) that previously kept us in continuous survival mode don’t affect us anymore.

We celebrate the Remembrance of the Resurrectables each year. A ceremony for remembering all of the patients that are in Cryonic Suspension awaiting an eventual return to a full healthy life.

Go To https://youtu.be/NgdwYAWCy88 for part 1 of our service: Dr. Richard Olree “Minerals for Telomeres” and “Age Reversal Update” with Bill Faloon.

“Our task is to make nature, the blind force of nature, into an instrument of universal resuscitation and to become a union of immortal beings.“
- Nikolai F. Fedorov.

We hold faith in the technologies & discoveries of humanity to END AGING and Defeat involuntary Death within our lifetime.

Working to Save Lives with Age Reversal Education.

But even junk has hidden treasures. Studies found variations in these unsequenced regions were intricately involved in human health, from aging to conditions like cancer and developmental disorders like autism. In 2022, a landmark study finally resolved the genomic unknown, completely sequencing the remaining eight percent of undeciphered DNA remaining.

Now, scientists are discovering that some genetic sequences encode proteins that lack any obvious ancestors, what geneticists call orphan genes. Some of these orphan genes, the researchers surmise, arose spontaneously as we evolved, unlike others that we inherited from our primate ancestors. In a paper published Tuesday in the journal Cell Reports, researchers in Ireland and Greece found around 155 of these smaller versions of DNA sequences called open reading frames (or ORF) make microproteins potentially important to a healthy cell’s growth or connected to an assortment of ailments like muscular dystrophy and retinitis pigmentosa, a rare genetic disease affecting the eyes.

“This is, I think, the first study looking at the specific evolutionary origins of these small ORFs and their microproteins,” Nikolaos Vakirlis, a scientist at the Biomedical Sciences Research Center “Alexander Fleming” in Greece and first author of the paper, tells Inverse. It’s an origin, he says, that’s been mired in much question and mystery.