EXCLUSIVE: Clones are the next step in extending human life, scientist believes The technique has proved successful in animals but not yet worked in people Dr Alex Zhavoronkov believes it will offer ‘spare’ organs for people as they age Regardless of the huge strides scientists have made towards reaching the elusive goal, immortality remains a pipedream.
Injury to the spinal cord often leads life changing disability, with decreased or complete loss of sensation and movement below the site of injury. From drugs to transplantation, there are many scientific advances aiming to restore function following spinal cord injury.
One promising approach is the use of stem cell derived neurons to replace those damaged. New research from the Centre for Gene Therapy & Regenerative Medicine and Centre for Neurodevelopment at King’s College London hopes to improve on this approach by providing pure populations of neurons made from stem cells.
The spinal cord is a delicate structure, with neurons carry messages from your brain to the rest of your body to allow movement and sensation. Integral to this system are interneurons, or the cells that relay information between your brain and other neurons. Research has previously shown that transplanting a class of interneurons, ventral spinal interneurons, to treat spinal cord injury in animal models provides promising recovery of sensory and motor function.
Seminar summary: https://foresight.org/summary/bioelectric-networks-taming-th…-medicine/
Program & apply to join: https://foresight.org/biotech-health-extension-program/
Foresight Biotech & Health Extension Meeting sponsored by 100 Plus Capital.
Michael Levin, Tufts Center for Regenerative and Developmental Biology.
Bioelectric Networks: Taming the Collective Intelligence of Cells for Regenerative Medicine.
Michael Levin, Distinguished Professor in the Biology department and Vannevar Bush Chair, serves as director of the Tufts Center for Regenerative and Developmental Biology. Recent honors include the Scientist of Vision award and the Distinguished Scholar Award. His group’s focus is on understanding the biophysical mechanisms that implement decision-making during complex pattern regulation, and harnessing endogenous bioelectric dynamics toward rational control of growth and form. The lab’s current main directions are:
Age catches up with us all eventually, but in some people the right genes can make that chase into our twilight years a relatively leisurely one.
A few years ago Italian researchers discovered something special about people who live well into their 90s and beyond: they commonly have a version of a gene called BPIFB4 that protects against cardiovascular damage and keeps the heart in good shape for a longer period of time.
By introducing the mutated gene into older mice, the scientists have now seen how the variant rewinds markers of biological heart aging by the equivalent of more than 10 human years.
Bryan Johnson is 45 years old but, according to a new report, his test results show he has the heart of a 37-year-old and the lungs of a young adult.
Johnson is a biotech entrepreneur who hopes to game nature’s course of aging and have the organs and health of an 18-year-old by going through an intense data-driven experimental program he’s called Project Blueprint.
According to a recent Bloomberg profile of the CEO, Johnson could spend up to $2 million on his body this year and there are early glimpses that show he may be on track to unlocking the secret to age reversal.
Test results from doctors suggest that Johnson has the heart of a 37-year-old, the skin of a 28-year-old, and the lung capacity of an 18-year-old, Bloomberg’s Ashlee Vance reported.
Bryan Johnson is 45 years old but, according to a new report, his test results show he has the heart of a 37-year-old and the lungs of a young adult.
Johnson is a biotech entrepreneur who hopes to game nature’s course of aging and have the organs and health of an 18-year-old by going through an intense data-driven experimental program he’s called Project Blueprint.
According to a recent Bloomberg profile of the CEO, Johnson could spend up to $2 million on his body this year and there are early glimpses that show he may be on track to unlocking the secret to age reversal.
Test results from doctors suggest that Johnson has the heart of a 37-year-old, the skin of a 28-year-old, and the lung capacity of an 18-year-old, Bloomberg’s Ashlee Vance reported.
billion companies — here’s why he thinks investors should get in early on one of tech’s unsexy, neglected markets” | >
Does the secret to reaching extreme old age lie in lifestyle or genetics? Story at a glance America’s population is aging, with more people living to be 100. Reaching extreme old age depends on multiple factors like location, gender, lifestyle and parental age of death.
Phil Newman, Founder and CEO, Longevity. Technology at Rejuvenation Startup Summit 2022.
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Advancing Geroscience & Gerotherapeutics — Dr. Nir Barzilai, MD, Albert Einstein College of Medicine.
Dr. Nir Barzilai, MD (https://www.einsteinmed.edu/faculty/484/nir-barzilai/) is the Director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. He is the Ingeborg and Ira Leon Rennert Chair of Aging Research, professor in the Departments of Medicine and Genetics, and member of the Diabetes Research Center and of the Divisions of Endocrinology & Diabetes and Geriatrics.
Dr. Barzilai’s research interests are in the biology and genetics of aging, with one focus of his team on the genetics of exceptional longevity, where they hypothesize and demonstrate that centenarians (those aged 100 and above) may have novel protective genes, which allow the delay of aging or for the protection against age-related diseases. The second focus of his work, for which Dr. Barzilai holds an NIH Merit award, is on the metabolic decline that occurs during aging, and his team hypothesizes that the brain leads this decline with some very interesting neuro-endocrine connections.
Rejuvenating an older person’s blood may now be within reach, based on recent findings from Passegué’s lab published in Nature Cell Biology(link is external and opens in a new window).
Passegué, with her graduate student Carl Mitchell, found that an anti-inflammatory drug, already approved for use in rheumatoid arthritis, can turn back time in mice and reverse some of the effects of age on the hematopoietic system.
Nature article:
https://www.nature.com/articles/s41556-022-01053-0
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