Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with klotho, a longevity factor, could enhance cognition in human-relevant models such as in nonhuman primates is unknown and represents a major knowledge gap in the path to therapeutics. We validated the rhesus form of the klotho protein in mice showing it increased synaptic plasticity and cognition. We then found that a single administration of low-dose, but not high-dose, klotho enhanced memory in aged nonhuman primates. Systemic low-dose klotho treatment may prove therapeutic in aging humans.
The earlier that Alzheimer’s disease and other similar conditions can be spotted, the better the treatment options are, and scientists have discovered a blood biomarker that could signal the risk of dementia many years in advance.
A team from the National Institute on Aging, the University of Texas, and the Johns Hopkins Bloomberg School of Public Health in the US, as well as other institutions across the world, looked at data on 10,981 individuals collected across the course of 25 years.
In particular, the researchers analyzed the proteome of these individuals: the complete set of proteins expressed in a body, driving all kinds of biological processes from cell communication to hormone levels.
Silicon Valley tech bro Bryan Johnson claims he’s shaved five years off his biological age. Longevity mastermind David Sinclair, Ph.D., says tests show his biological age is a full decade younger than the 53 candles on his birthday cake. Sixty-three-year-old functional medicine doctor Mark Hyman, M.D., say tests clock his biological age at a young 43. But can aging really be cured? Maybe not—but adopting or eschewing certain lifestyle habits to add years to your life.
When it comes to understanding how to reverse aging, there are tests on the market that claim to be able to help you do that. They calculate your ‘biological age’ to see how your body could be aging across various cell-level metrics versus the number of candles on your birthday cake.
I expect this to double over at least 2 maybe 3 times between now and 2030. AND, we here need to back it at every step if we really want indefinite life extension. Time to pick a side is right now.
The arrival of artificial intelligence into healthcare means everyone could one day have a doctor in their pocket, but Google’s chief health officer has urged caution about what AI can do and what its limits should be.
“There’s going to be an opportunity for people to have even better access to services, [and] to great quality services,” Dr Karen DeSalvo told Guardian Australia in an interview last week.
Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, in collaboration with researchers at the University of California Santa Barbara, today announced a drug discovery platform that enables precise control of the integrated stress response (ISR), a biological pathway that is activated by cells in response to a wide variety of pathological and aging-associated conditions.
A new publication, “Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape,” authored by company founders and featured on the cover of Cell Systems describes a technique that triggers the ISR virtually using light and demonstrates how the accumulation of stress over time shifts a cell’s reaction from adaptation to apoptosis (programmed cell death).
“In a very real way, our platform puts cells into a virtual reality, making them experience stress in the absence of physical stressors,” said Maxwell Wilson, Ph.D., a co-founder of Integrated Biosciences and Assistant Professor of Molecular, Cellular, and Developmental Biology at the University of California Santa Barbara.
Ageing is not an inevitable fact of life – many animals have already found ways to delay death. Their clues might help us all enjoy longer and healthier lives.
Autophagy biology has emerged as a ray of hope in addressing age-related diseases such as neurodegenerative disorders. Substantial effort in academia has been directed at advancing our understanding of the field and paving the way for ground-breaking therapies. But with genuine challenges in harnessing the power of autophagy and in developing effective therapies in this disease area, how close are we to really finding the first autophagy boosting drugs…?
The devastating impact of neurodegenerative diseases such as Parkinson’s, Alzheimer’s and amyotrophic lateral sclerosis (ALS), the most common form of Motor Neurone Disease (MND), cannot be overstated. According to the WHO, neurological diseases affect over a billion people globally and are the leading cause of disability and the second leading cause of death worldwide [1, 2]. Incidence is increasing too, predominantly driven by population growth and aging. And, with no prospect of a cure, people who develop these conditions face a bleak future.
Justifiably, this disease area has been the subject of intensive research for many years and there have been some breakthroughs along the way, possibly offering hope for the development of new therapies. However, translating scientific breakthroughs into viable drugs for patients has been enormously challenging.
In the 1990 fantasy drama — Truly, Madly, Deeply, lead character Nina, (Juliet Stevenson), is grieving the recent death of her boyfriend Jamie (Alan Rickman). Sensing her profound sadness, Jamie returns as a ghost to help her process her loss. If you’ve seen the film, you’ll know that his reappearance forces her to question her memory of him and, in turn, accept that maybe he wasn’t as perfect as she’d remembered. Here in 2023, a new wave of AI-based “grief tech” offers us all the chance to spend time with loved ones after their death — in varying forms. But unlike Jamie (who benevolently misleads Nina), we’re being asked to let artificial intelligence serve up a version of those we survive. What could possibly go wrong?
While generative tools like ChatGPT and Midjourney are dominating the AI conversation, we’re broadly ignoring the larger ethical questions around topics like grief and mourning. The Pope in a puffa is cool, after all, but thinking about your loved ones after death? Not so much. If you believe generative AI avatars for the dead are still a way out, you’d be wrong. At least one company is offering digital immortality already — and it’s as costly as it is eerie.
Re;memory, for example, is a service offered by Deepbrain AI — a company whose main business includes those “virtual assistant” type interactive screens along with AI news anchors. The Korean firm took its experience with marrying chatbots and generative AI video to its ultimate, macabre conclusion. For just $10,000 dollars and a few hours in a studio, you can create an avatar of yourself that your family can visit (an additional cost) at an offsite facility. Deepbrain is based in Korea, and Korean mourning traditions include “Jesa”, an annual visit to the departed’s resting place.
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Ben Goertzel, Chief scientist of Hanson Robotics and co-creator of the world’s most famous android citizen, Sophia imagines how the “upload my mind” button will look like in the future.
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Some best practices for longevity can be a real bummer. Everyone knows that regular exercise is good for them, but not everyone enjoys it. Eating a few cups of veggies with every meal may not be as fun as a side of fries.
But every so often, the things that are good for us feel good too. Case in point: the humble massage.
A massage for most people is a spa-day splurge, but it’s also an ancient medicinal practice. A thorough rub-down is a great way to celebrate the end of a stressful semester, but there’s more to it than much-deserved relaxation. At its best, a good massage improves bodily motion and function. While science doesn’t say that each massage adds years to your life (not yet, anyway), the benefits of regular massages (for those lucky enough to get them) can add up over time.
