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In the pursuit of extending healthy human lifespans, scientists have achieved a remarkable breakthrough that marks a significant milestone in the field. Researchers from Taipei Medical University in Taiwan have uncovered a genetic modification in mice that can empower cancer-killing cells, increasing their effectiveness by two to seven times while extending their lifespan by up to 20 percent.

Building upon last year’s groundbreaking study, the scientists have now successfully replicated these extraordinary outcomes in ordinary mice through a single transplant of blood stem cells. The findings, published in the scientific journal Cold Spring Harbor Protocols, hold immense importance, according to Che-Kun James Shen, the lead researcher of the study. He believes that these findings could have profound implications for human health and anticipates that clinical trials could commence as early as the end of this year or next year.

The initial discovery involved identifying an amino acid, known as KLF1, that, when altered, preserves the youthful characteristics of the mice. This includes improved motor function, enhanced learning and memory, as well as more effective anti-cancer cells. Additionally, the mice exhibited darker and shinier hair, and a significant reduction in fibrosis—a process associated with impaired organ functioning that occurs during aging.

Age-related hearing loss impacts one in three adults between the ages of 64 and 75 in the US, and around half of these numbers are down to genes.

The extra kicker, though, is that because hearing involves a complex genetic toolkit, it also makes this kind of hearing loss incredibly difficult to treat.

A team of researchers has for the first time targeted age-related genetic hearing loss in a much older cohort of mice, which had a mutation of the human transmembrane serine protease 3 (TMPRSS3) gene that results in autosomal recessive deafness 8/10 (DFNB8/DFNB10).

Glioblastoma Multiforme (GBM) is the most aggressive and most common primary malignant brain tumor. The age of GBM patients is considered as one of the disease’s negative prognostic factors and the mean age of diagnosis is 62 years. A promising approach to preventing both GBM and aging is to identify new potential therapeutic targets that are associated with both conditions as concurrent drivers. In this work, we present a multi-angled approach of identifying targets, which takes into account not only the disease-related genes but also the ones important in aging. For this purpose, we developed three strategies of target identification using the results of correlation analysis augmented with survival data, differences in expression levels and previously published information of aging-related genes.

I quoted and responded to this remark:

“
we probably will not solve death and this actually shouldn’t be our goal.” Well nice as she seems thank goods Dr Levine does not run the scientific community involved in rejuvenation.

The first bridge looks like it’s going to be plasma dilution and this may come to the general population in just a few short years. People who have taken this treatment report things like their arthritis and back pain vanishing.

After that epigentic programming to treat things that kill you in old age. And so on, bridge after bridge. if you have issues with the future, some problem with people living as long as they like, then by all means you have to freedom to grow old and die. That sounds mean but then I think it’s it’s mean to inform me I have to die because you think we have to because of “progress”. But this idea that living for centuries or longer is some horrible moral crime just holds no water.


Science can’t stop aging, but it may be able to slow our epigenetic clocks.

In short blood dilution is very, very good for you.


In this talk, Dr. Irina Conboy discusses the role of repair and regeneration in lifespan and healthspan, contending that these factors, rather than entropy and time progression, truly govern our aging process. She describes the research her team is pursuing, investigating whether improving the efficiency of bodily repair in older individuals could effectively make them younger. She suggests that biological age could potentially be reversed and discusses heterochronic parabiosis and plasma dilution as potential ways to accomplish that. Conboy highlights recent research suggesting that old blood has a greater impact on cellular health and function than young blood. She presents her team’s experimental research on the rejuvenation effects of plasma dilution, demonstrating its significant impact on reducing senescence, neuroinflammation, and promoting neurogenesis in the brains of old mice.

00:00:00 — Importance of repair and regeneration in aging.
00:04:45 — Young blood vs. old blood, heterochronic parabiosis.
00:10:17 — Plasma dilution is key.
00:15:49 — Kiana Aran’s blood heterochronicity on a chip.
00:17:56 — The role of senescence in parabiosis and blood exchange.
00:27:53 — Measurements of biological age.
00:36:57 — Systemic calibration is globally rejuvenative.
00:37:30 — Conclusions.

About the Speaker:
Irina Conboy is a Professor at the University of California, Berkeley in the Department of Bioengineering. Her discovery of the rejuvenating effects of young blood through parabiosis in a seminal paper published in Nature in 2005 paved the way for a thriving field of rejuvenation biology. The Conboy lab currently focuses on broad rejuvenation of tissue maintenance and repair, stem cell niche engineering, elucidating the mechanisms underlying muscle stem cell aging, directed organogenesis, and making CRISPR a therapeutic reality.

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Year 2022 This new protein Newtic1 holds promise to fully understanding limb regeneration in humans. Still though genetic engineering will be needed to fully integrate the ability for limb and body part regeneration.


The animal kingdom exhibits a plethora of unique and surprising phenomena or abilities that include, for some animals, the ability to regenerate body parts irrespective of age. Now, researchers from Japan have discovered that the mechanisms behind this peculiar ability in newts have a few surprises of their own.

The Forever Healthy Foundation is pleased to announce the second edition of the Rejuvenation Startup Summit, following the inaugural Rejuvenation Startup Summit in 2022 with more than 400 participants from over 30 countries. It will take place on 10–11 May 2024 in Berlin. The Rejuvenation Startup Summit is the world’s largest in-person gathering of longevity startups. It brings together startups, members of the longevity venture capital / investor ecosystem, and researchers interested in starting or joining a startup – all with the goal of accelerating the development of the rejuvenation biotech industry.

At Blueprint we’ve explored and evaluated hundreds of anti-aging therapies.

Recently, we had a daring idea: what if my father, son and I completed the world’s first ever multi-generational plasma exchange?

Plasma is the yellowish, liquid part of your blood. There is emerging evidence that plasma exchanges may offer various health benefits.

Nervous but excited, we travelled to a transfusion centre in Dallas Texas to make it happen.

đŸ§Ș WHAT IS BLUEPRINT
I’ve invested millions of dollars building the world’s leading anti-aging protocol, becoming the most measured human in history. Blueprint is an algorithm, built by science, that takes better care of me than I can myself.

And it’s available to you for free. Check out the Blueprint website for recipes, exercise, and other protocols. Become the next evolution of human.

Lifespan by simply slowing the aging of an organ, such as the intestine? CNRS researchers have discovered how to extend the life expectancy of zebrafish by reactivating a gene within intestinal cells. The results were published in the journal Nature Aging on May 4, 2023.

The intestine plays a crucial role in an anti-aging approach as well as general health. Over a century ago, Elie Metchnikov observed that aging ensued from increased inflammation of the intestine and microbial infiltration within . The more we age, the less the serves as a barrier, allowing the undesirable particles and bacteria that cause the more rapid aging of the organism to pass through.

In a new study, Miguel Godinho Ferreira and his team at the Institute for Research on Cancer and Aging (Ircan) in Nice (CNRS/Inserm/UniversitĂ© CĂŽte d’Azur) have studied the impact on aging of telomere length in the intestinal cells of zebrafish. As with humans, these chromosome extremities shrink faster in the than in other organs during the course of a life, which is why this process plays such an important role in aging.