Lifeboat Foundation

Researchers at the National Heart, Lung, and Blood Institute at NIH, Bethesda, have discovered a potential breakthrough for people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), marked by extreme exhaustion, post-exertional malaise and cognitive issues.

In a paper, “WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome,” published in PNAS, the team details the influence of increased WASF3 proteins on the assembly of mitochondrial proteins, hampering energy production.

The study focused on a woman (S1) who experienced severe long-term fatigue. Measuring her muscles for phosphocreatine regeneration after exercise revealed a significant delay in mitochondrial ATP synthesis capacity. This discovery was followed up with a cell assay which found increased phospho-activation of an enzyme in a signaling pathway (MPAK).

A new study led by University of Maryland physicists sheds light on the cellular processes that regulate genes. Published in the journal Science Advances, the paper explains how the dynamics of a polymer called chromatin—the structure into which DNA is packaged—regulate gene expression.

Through the use of machine learning and statistical algorithms, a research team led by Physics Professor Arpita Upadhyaya and National Institutes of Health Senior Investigator Gordon Hager discovered that chromatin can switch between a lower and higher mobility state within seconds. The team found that the extent to which chromatin moves inside cells is an overlooked but important process, with the lower mobility state being linked to gene expression.

Notably, transcription factors (TFs)—proteins that bind specific DNA sequences within the chromatin polymer and turn genes on or off—exhibit the same mobility as that of the piece of chromatin they are bound to. In their study, the researchers analyzed a group of TFs called nuclear receptors, which are targeted by drugs that treat a variety of diseases and conditions.

Google DeepMind researchers have finally found a way to make life coaching even worse: infuse it with generative AI.

According to internal documents obtained by The New York Times reports, Google and the Google-owned DeepMind AI lab are working with “generative AI to perform at least 21 different types of personal and professional tasks.” And among those tasks, apparently, is an effort to use generative AI to build a “life advice” tool. You know, because an inhuman AI model knows everything there is to know about navigating the complexities of mortal human existence.

As the NYT points out, the news of the effort notably comes months after AI safety experts at Google said, back in just December, that users of AI systems could suffer “diminished health and well-being” and a “loss of agency” as the result of taking AI-spun life advice. The Google chatbot Bard, meanwhile, is barred from providing legal, financial, or medical advice to its users.

In a recent pre-print study posted to the medRxiv* server, researchers conducted a comprehensive genome-wide association study (GWAS) to elucidate the genetic architecture of circulating retinol, identify its potential causal relationships with various clinical phenotypes, and evaluate its therapeutic or nutritional implications.

Study: Genetic influences on circulating retinol and its relationship to human health. Image Credit: SciePro/Shutterstock.com.

*Important notice: medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.

What if we could identify the earliest warning signs of cardiovascular disease from a simple saliva sample? Scientists think they have found a way to do so. Gum inflammation leads to periodontitis, which is linked with cardiovascular disease.

The team used a simple oral rinse to see if levels of white blood cells —an indicator of gum inflammation —in the saliva of healthy adults could be linked to warning signs for cardiovascular disease. they found that high levels correlated with compromised flow-mediated dilation, an early indicator of poor arterial health.

“Even in young healthy adults, low levels of oral inflammatory load may have an impact on cardiovascular health—one of the leading causes of death in North America,” said Dr. Trevor King of Mount Royal University, corresponding author of the study published in Frontiers in Oral Health.

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One of Google’s AI units is using generative AI to develop at least 21 different tools for life advice, planning and tutoring, The New York Times reported Wednesday.

Google’s DeepMind has become the “nimble, fast-paced” standard-bearer for the company’s AI efforts, as CNBC previously reported, and is behind the development of the tools, the Times reported.

Continue reading “Google reportedly building A.I. that offers life advice” »

Find out more about how they are used in allergy, asthma and immunology treatments.

Exercise has many health benefits, from improving brain health to strengthening bones and muscles. Included in the vast array of advantages associated with exercise is cancer prevention and control.

The scientific literature suggests that physical activity mobilizes immune cells, activating them to fight cancer. This idea prompted an investigation into the interplay between exercise and immunity, the results of which were recently published in Scientific Reports.

The study investigated how 10-minute exercise sessions impact immune cells in patients recently diagnosed with breast cancer. The exercise regimen in the study consisted of pedaling a supine bicycle (laying on the back while cycling the legs) for ten minutes. This type of activity, considered “acute exercise,” is loosely defined as single bouts of physical activity. Acute exercise directly impacts circulation, and when the blood starts pumping, immune cells travel throughout the body, becoming more likely to encounter cancerous cells.

On this episode, Daniel Schmachtenberger returns to discuss a surprisingly overlooked risk to our global systems and planetary stability: artificial intelligence. Through a systems perspective, Daniel and Nate piece together the biophysical history that has led humans to this point, heading towards (and beyond) numerous planetary boundaries and facing geopolitical risks all with existential consequences. How does artificial intelligence, not only add to these risks, but accelerate the entire dynamic of the metacrisis? What is the role of intelligence vs wisdom on our current global pathway, and can we change course? Does artificial intelligence have a role to play in creating a more stable system or will it be the tipping point that drives our current one out of control?

About Daniel Schmachtenberger:
Daniel Schmachtenberger is a founding member of The Consilience Project, aimed at improving public sensemaking and dialogue.

Continue reading “Daniel Schmachtenberger: ‘Artificial Intelligence and The Superorganism’ | The Great Simplification” »