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Doggie DNA startup wants to learn about human diseases from dog drool

Finally there’s a use for dog drool: this spring, a new startup called Embark plans to launch a DNA testing kit for dogs that will tell owners about their canine’s ancestry, and disease risk. That’s not all the founders have in mind though; they may be aiming at human diseases by enlisting our longtime best friends.

Soon, interested pooch lovers will be able to swab their dogs’ slimy cheeks and mail in the sample. By extracting DNA from the swab, Embark’s founder says they’ll be able to trace a dog’s ancestry on a global level. The “Embark Dog DNA Test Kit” will also look for genetic variants that are associated with more than 100 diseases, and inform owners if their dog has a higher than average chance of developing one of them. The kit will also tell owners if their dog is likely to pass disease-associated mutations to a pup — which will likely be valuable information for breeders. Because of this, Embark’s founders say their product will be the most complete kit of its kind. At least, that’s the idea that Embark’s founders will be pitching today at SXSW.

For the company’s founders, the real objective will be the research they’ll be able to conduct with the DNA samples; that became clear when I spoke to two of Embark’s founders on the phone last week. They spent the first 10 minutes of the call talking about the potential of dog genetics to deliver advancements in human health. In fact, they were so enthusiastic about their future research that I had to interrupt them to steer the conversation back to the product we were supposed to discuss.

Light illuminates the way for bio-bots

CHAMPAIGN, Ill. — A new class of miniature biological robots, or bio-bots, has seen the light — and is following where the light shines.

The bio-bots are powered by muscle cells that have been genetically engineered to respond to light, giving researchers control over the bots’ motion, a key step toward their use in applications for health, sensing and the environment. Led by Rashid Bashir, the University of Illinois head of bioengineering, the researchers published their results in the Proceedings of the National Academy of Sciences.

“Light is a noninvasive way to control these machines,” Bashir said. “It gives us flexibility in the design and the motion. The bottom line of what we are trying to accomplish is the forward design of biological systems, and we think the light control is an important step toward that.”

Welcome to Major Mouse Testing Project | Major Mouse Testing Project

SENS has kindly commented about MMTP and the impact our research should have on aging. We launch a fundraiser in April to test senolytics (ApoptoSENS) with a planned follow up to combine this with stem cell therapy (RepleniSENS). It is time to put the engineering approach to aging to the test!


Some drugs tested have been found to increase mouse lifespan such as Metformin and Rapamycin for example and are considered for human testing. Many more substances have never been tested and we do not know if they might extend healthy lifespan.

Machine learning underpins data-driven AI: Una-May O’Reilly

Another data scientist with pragmatic thinking which is badly needed today. Keeping it real with Una-May O’Reilly.


Mumbai: Una-May O’Reilly, principal research scientist at Anyscale Learning For All (ALFA) group at the Massachusetts Institute of Technology Computer Science and Artificial Intelligence Laboratory, has expertise in scalable machine learning, evolutionary algorithms, and frameworks for large-scale, automated knowledge mining, prediction and analytics. O’Reilly is one of the keynote speakers at the two-day EmTech India 2016 event, to be held in New Delhi on 18 March.

In an email interview, she spoke, among other things, about how machine learning underpins data-driven artificial intelligence (AI), giving the ability to predict complex events from predictive cues within streams of data. Edited excerpts:

When you say that the ALFA group aims at solving the most challenging Big Data problems—questions that go beyond the scope of typical analytics—what do you exactly mean?

Typical analytics visualize and retrieve direct information in the data. This can be very helpful. Visualizations allow one to discern relationships and correlations, for example. Graphs and charts plotting trends and comparing segments are informative. Beyond its value for typical analytics, one should also be aware that the data has latent (that is, hidden) predictive power. By using historical examples, machine learning makes it possible to build predictive models from data. What segments are likely to spend next month? Which students are likely to drop out? Which patient may suffer an acute health episode? Predictive models of this sort rely upon historical data and are vital. Predictive analytics is new, exciting and what my group aims to enable technologically.

‘Artificial pancreas’ is one of new tech devices aimed at diabetes

Wearables and other connected devices have been available to help treat chronic conditions like asthma and heart disease for a while now. But thus far, the nation’s 30 million diabetics haven’t seen much to help them improve their health or reduce the daily grind of finger pricks and needle pokes.

The $2.5 billion connected-care industry may be off to a late start in diabetes, but it’s making up for lost time. A new breed of connected glucometers, insulin pumps and smartphone apps is hitting the market. They promise to make it easier for diabetics to manage the slow-progressing disease and keep them motivated with feedback and support. In as little as two years, the industry plans to take charge of the entire uncomfortable, time-consuming routine of checking and regulating blood-sugar levels with something called an artificial pancreas. Such systems mimic the functions of a healthy pancreas by blending continuous glucose monitoring, remote-controlled insulin pumps and artificial intelligence to maintain healthy blood-sugar levels automatically.

For Jeroen Tas, CEO of Philips’ Connected Care and Health Informatics unit, diabetes management is also personal: his daughter Kim is diabetic.

NIH awards grant to upstart for nanotech, regenerative spinal implants

New funding awarded by DARPA on new spinal implants; this should make some commercial pilots that I know happy.


Carmel, IN-based startup Nanovis is no stranger to nabbing research grants. It’s just nabbed one from the National Institutes of Health for preclinical research on the use of its porous Forticore interbody fusion devices in combination with nanotube technology. The combination is expected to result in a surface that mimics nature and encourages regeneration around an implant.

Nanovis has previously gotten 8 competitive peer-reviewed grants from the NIH and other research organizations; this is its second NIH grant. In September 2014, it got FDA clearance for its FortiCore interbody fusion devices and then last October it launched an expanded FortiCore line.

“Gaining the attention and support of the NIH for Nanovis’ technology platforms and research is gratifying,” said Nanovis CEO Matt Hedrick in a statement. “Our deeply porous FortiCore interbody fusion device are increasingly being adopted by leading surgeons and hospital networks driving accelerated company growth. As we progress forward, we continue to invest in the fundamental science at the core of our uniquely differentiated technologies. Grants from the NIH help us continue to discover potential applications to improve the future of healthcare.”

You can now sequence your entire genome for under $1,000

It wasn’t all that long ago that the first human genome was sequenced – a massive, globally orchestrated scientific undertaking that took years and some US$3 billion to achieve.

Since then, rapid advancements in genetic technology and techniques have seen the cost and time required for genome sequencing drop dramatically, leading to this week’s remarkable announcement: the first whole genome sequencing service for consumers that costs less than $1,000.

At just $999, myGenome, from US-based genetics startup Veritas Genetics, is being billed by its makers as the first practical and affordable way for people to access unparalleled personal data on their individual genetic code. The company claims its personalised service offers an accessible way to keep tabs on your current health, keep you abreast of any potential future issues, and even know what inherited genetics you might pass onto your children.

Death Reversal — The Reanima Project — Research Whose Time Has Come

I have spent the last 30 years in various aspects of the biopharmaceutical industry, which for the most part has been a very rewarding experience.

However, during this time period, having been immersed many different components of therapeutic development and commercialization, one thing has always bothered me: a wide array of promising research never makes it off the bench to see the translational light of day, and gets lost in the historical scientific archives.

I always believed that scientific progress happened in a very linear narrative, with each new discovery supporting the next, resulting ultimately in an eventual stairway of scientific enlightenment.

What the reality turned out to be was much more of a fragmented, research “evolutionary tree”, with dozens of potential pathways, only very few branches of which ever resulted in scientific maturity, and not always the most fruitful ones by any means.

The premature extinction of these promising discovery pathways were the result of a variety of factors, including, but not limited to, funding priorities, competing industrial interests, “out of vogue” concepts, lack of intellectual properties, non-existent regulatory models, conflicted legislative initiatives, and even religious implications.

In 2016, as in previous years, we continue to see these “valleys of death” swallow up pathways of scientific possibility, with few popular segments attracting the majority of attention and support.

gene sequencing

The preponderance of resources focused on the somatic mutation model of carcinogenesis, despite an endless range of research highlighting that the disease is extremely heterogenic and rarely ever follows such a clonal model, is one example that continues to be inappropriately manifested in the oncology system, decades into the “war on cancer”.

On a similar plane, the jettisoning of most studies of the biophysical aspects of human genetics, despite the gross incompleteness offered by the central dogma to explain higher biological form and function, is another example that has become all too pervasive in the research community.

And then there are the areas of human consciousness, memory, and information processing / storage, where in many ways we are still operating in the dark ages, with materialists and dualists battling it out for centuries.

One topic that I have written quite a bit about is that of death, specifically that of the death of the human brain — http://www.singularityweblog.com/is-death-reversible/

brainimage

While I am a staunch supporter and advocate of the life-extension / anti-aging movement, I am equally vocal about our need to develop technologies, products, and services that can actually reverse our ultimate transition between the living and dead states, a transition that occurs annually for 60 million humans around the globe.

Death, however, is unfortunately seen by many as a natural, biological progression for human beings, and in many circles, deemed an unnecessary area of scientific research and exploration.

I beg to differ.

Far too often, death arrives too early and too unexpectedly for many of us and our loved ones. And the best modern medicine has to offer today is “Sorry. There is nothing else we can do.”

But what if there was?

There are a variety of species across the natural world that are capable of regenerating and repairing themselves from forms of severe CNS damage that bring them to the transitional grey zone between life and death. Along the evolutionary timeline however, this ability gradually disappeared hundreds of millions of years ago and does not manifest in higher species.

lizard and lady

Now, in the 21st century, with the convergence of the disciplines of regenerative biology, cognitive neuroscience, and clinical resuscitation, we may finally be poised to take back these capabilities for humans.

Over the years, clinical science has focused heavily on preventing such life and death transitions and made some initial progress with suspended animation technologies, such as therapeutic hypothermia. But once we transition through the brain death window, currently defined by the medical establishment as “irreversible” (per the 1968 Ad Hoc Committee of the Harvard Medical School definition), we are technically no longer alive.

surgeons

To add insult to injury, a human can be declared dead, even while our bodies can still circulate blood, digest food, excrete waste, balance hormones, grow, sexually mature, heal wounds, spike a fever, and gestate and deliver a baby. It is even acknowledged by thought leaders that recently brain dead humans still may have residual blood flow and electrical nests of activity in their brains, just not enough to allow for an integrated functioning of the organism as a whole.

Several prominent cases in the media over the past few years have further served to highlight the current situation, as well as the substantial anatomical and functional differences between the state known as brain death, and other severe disorders of consciousness, such as coma, and the vegetative and minimally conscious states.

It is now time to take the necessary steps to provide new possibilities of hope, in order to counter the pain, sorrow, and grief that is all too pervasive in the world when we experience a loved one’s unexpected or untimely death, due to lesions which might be potentially reversible with the application of promising neuro-regeneration and neuro-reanimation technologies and therapies.

bqaproduction

It is time to undertake the required research, based on 2016 technological knowledge, in order to bring about such transformational change.

My name is Ira S. Pastor and I am the CEO of the biotechnology company Bioquark Inc.

Welcome to the unveiling of the Reanima project.

Reanima Video

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