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Conditioning the lungs with interferon-gamma, a natural immune system protein (cytokine) best known for fighting bacterial infections, appears to be a strong antiviral for SARS-CoV-2, according to National Institutes of Health scientists and colleagues. Their new study, published in Nature Communications, shows in two different mouse models that when a bacterial infection triggers the release of interferon-gamma in the lungs, those animals subsequently are protected from infection by SARS-CoV-2, the virus that causes COVID-19. The investigators further report that using recombinant interferon-gamma in the nose of study mice at the time of viral exposure substantially reduces SARS-CoV-2 infection and COVID disease.

The lead project scientists suggest testing interferon-gamma further, alone and in combination with other treatments, to limit early SARS-CoV-2 infection in people. They also hypothesize that people with prior bacterial infections that naturally release interferon-gamma in their lungs may be less susceptible to COVID-19.

NIH’s National Institute of Allergy and Infectious Diseases (NIAID) led the project with collaborators at Malaghan Institute of Medical Research in New Zealand.

Researchers at UT Southwestern Medical Center have developed a novel artificial intelligence (AI) model that analyzes the spatial arrangement of cells in tissue samples. This innovative approach, detailed in Nature Communications, has accurately predicted outcomes for cancer patients, marking a significant advancement in utilizing AI for cancer prognosis and personalized treatment strategies.

“Cell spatial organization is like a complex jigsaw puzzle where each cell serves as a unique piece, fitting together meticulously to form a cohesive tissue or organ structure. This research showcases the remarkable ability of AI to grasp these intricate spatial relationships among cells within tissues, extracting subtle information previously beyond human comprehension while predicting patient outcomes,” said study leader Guanghua Xiao, Ph.D., Professor in the Peter O’Donnell Jr. School of Public Health, Biomedical Engineering, and the Lyda Hill Department of Bioinformatics at UT Southwestern. Dr. Xiao is a member of the Harold C. Simmons Comprehensive Cancer Center at UTSW.

Tissue samples are routinely collected from patients and placed on slides for interpretation by pathologists, who analyze them to make diagnoses. However, Dr. Xiao explained, this process is time-consuming, and interpretations can vary among pathologists. In addition, the human brain can miss subtle features present in pathology images that might provide important clues to a patient’s condition.

Polymer solar cells, known for their light weight and flexibility, are ideal for wearable devices. Yet, their broader use is hindered by the toxic halogenated solvents required in their production. These solvents pose environmental and health risks, limiting the appeal of these solar cells. Alternative solvents, which are less toxic, unfortunately, lack the same solubility, necessitating higher temperatures and prolonged processing times.

This inefficiency further impedes the adoption of polymer solar cells. Developing a method to eliminate the need for halogenated solvents could significantly enhance the efficiency of organic solar cells, making them more suitable for wearable technology.

In a recently published paper, researchers outline how improving molecular interactions between the polymer donors and the small molecule acceptors using side-chain engineering can reduce the need for halogenated processing solvents.

Introduction to spatial genomics The power of single-cell resolution Mapping the blueprint of health Case study: Bio-Techne Challenges and future prospects References Further reading

Spatial genomics is a cutting-edge field that combines genomics and spatial analysis to investigate the role of genomic features in disease at single-cell resolution.

Spatial genomics is a field of study that focuses on analyzing the spatial organization of genomic features within intact tissues. It involves the simultaneous analysis of various molecular components, including genomic DNA and RNA, through transcriptomic analysis and epigenetic modifications within their spatial context. These techniques aim to reveal the spatial relationships between the different genomic elements and provide insights into the organization and function of single cells within tissues, enabling the molecular connection of a particular genotype to its phenotype.

The Hubble Space Telescope recently suffered a glitch that made it go into safe mode, so it has not been collecting new science data since November 23. But on Friday, December 8, NASA will attempt to get the telescope up and running again by tweaking the operation of one of its three gyros.

The gyros are responsible for keeping the telescope pointed in the right direction, and an error in one of them put the telescope into safe mode to prevent any damage occurring to its hardware. Although it is theoretically possible for the telescope to operate with just one gyro, this would be less efficient and observing time would be lost as it would take longer for the telescope to switch between targets. So ideally, all three gyros can be operational.

The problem with the telescope was first shared on November 29, when NASA announced it was performing tests to understand the issue. Now, the tests are complete and NASA plans to resume operations. “After analyzing the data, the team has determined science operations can resume under three-gyro control,” NASA wrote in a new update. “Based on the performance observed during the tests, the team has decided to operate the gyros in a higher-precision mode during science observations. Hubble’s instruments and the observatory itself remain stable and in good health.”

Max Lugavere is a health and wellness expert, author and a diet advocate. Working out what to eat is hard. Which is odd because everybody does it. You’d think that the science of nutrition, a thing the entire human race relies on multiple times per day, would have some definitive answers. Thankfully Max can explain why it’s such a mess and give some solid principles we can all use. Expect to learn whether carnivore is an optimal diet for us all to follow, whether organic and non-GMO actually makes that much of a difference, what to look for in a magnesium supplement, the actual science of seed oils, whether sunscreen is a danger, why nutrition science is so contested, why calories matter but they aren’t all that matter and much more…

Rosacea is a skin condition that causes reddened skin and rash, usually on the nose and cheeks. There is no test for rosacea, so health care providers will typically diagnose it based on the appearance of the skin and your health history. They may run tests to rule out any other conditions. Learn more from NIAMS:

What is rosacea? It is a long-term disease that causes reddened skin and pimples, usually on the face. It can also make the skin thicker and cause eye problems.

Register for free and learn how to never be afraid of cancer again from health expert: Nathan Crane.

A wave of health concern is sweeping across Europe, echoing similar patterns of pediatric pneumonia seen in China. This concern stems from the increasing prevalence of a rather understated yet potent bacterium – Mycoplasma pneumonia, known for causing “walking pneumonia,” particularly for children.

Mycoplasma pneumoniae is a unique bacterium with the capability of triggering a spectrum of respiratory infections, ranging from mild to severe pneumonia. This pathogen predominantly targets school-aged children, with Public Health France indicating it accounts for 30–50% of community-acquired pneumonia infections in this demographic.

Pneumonia, as it stands, is a condition where the lungs’ air sacs become inflamed, potentially filling with fluid or pus. This results in symptoms that include coughing and difficulty breathing.