Lifeboat Foundation

Getting old may not be inevitable — scientists have found a way to turn back the clock on human and animal cells, making them look and behave like younger versions of themselves.

The researchers also used the method to treat mice with a rare disease that causes them to age prematurely and die early, and found that the method increased the animals’ lifespan by 30 percent. And, when normal mice received the treatment, they appeared to be rejuvenated, with some of their cells healing faster than normal in response to injury.

The researchers said that their findings may help scientists better understand the process of aging. One day, it may be possible to use a similar approach to ward off age-related diseases in humans, and thus improve people’s health and increase their lifespan, they said.

Continue reading “Aging May Be Reversible: Researchers Rejuvenate Older Mice” »

The team showed that a new form of gene therapy produced a remarkable rejuvenating effect in mice. After six weeks of treatment, the animals looked younger, had straighter spines and better cardiovascular health, healed quicker when injured, and lived 30% longer.

Juan Carlos Izpisua Belmonte, who led the work at the Salk Institute in La Jolla, California, said: “Our study shows that ageing may not have to proceed in one single direction. With careful modulation, ageing might be reversed.”

Continue reading “Ageing process may be reversible, scientists claim” »

Synthetic biology meets senolytics at Lifespan.io

We are developing tools to help researchers accurately target and remove dysfunctional cells in the body that have entered a state called “senescence”, and thereby assist in restoring it to youthful functionality. Please subscribe, share, and fund our campaign today! ►Campaign Link: https://www.lifespan.io/campaigns/cellage-targeting-senescen…c-biology/ ►Subscribe: https://www.youtube.com/user/LifespanIO?sub_confirmation=1

Continue reading “CellAge: Senescent Cell Targeting Technology Video” »

Dr. Aubrey de Grey from the SENS Research Foundation was kind enough to talk in support of CellAge and their campaign on Lifespan.io

We are developing tools to help researchers accurately target and remove dysfunctional cells in the body that have entered a state called “senescence”, and thereby assist in restoring it to youthful functionality. Please subscribe, share, and fund our campaign today! ►Campaign Link: https://www.lifespan.io/campaigns/cellage-targeting-senescen…c-biology/ ►Subscribe: https://www.youtube.com/user/LifespanIO?sub_confirmation=1

Continue reading “CellAge: Dr. Aubrey de Grey Endorsement Video” »

Lilly announced today that CYRAMZA® (ramucirumab) has been approved by the Singapore Health Sciences Authority to treat people with advanced gastric cancer, whose cancer has progressed after prior chemotherapy. First country in ASEAN to approve the new biologic therapy that extends survival in patients with advanced stomach cancer after prior chemotherapy

CYRAMZA^® (ramucirumab) is now available to Singaporeans living with advanced gastric cancer. The drug gained approval by Singapore’s Health Science’s Authority (HSA) earlier this year, marking the first regulatory approval in ASEAN. CYRAMZA is already available to patients in Japan, Korea, Taiwan and Hong Kong.

More proof that Precision Medicine can predict and solve complex health issues.

Brain scans could help predict response to psychotherapy for anxiety and depression.

Continue reading “Progress toward personalized treatments” »

Removing Glucosepane crosslinks from tissue is one of the most important things groups like SENS Research Foundation are doing and their progress relies on our support.

In this interesting open access paper, the authors propose that too little attention has been given to immune cell behavior in tissues rather than in blood, and that means that researchers have overlooked the possibility that age-related changes in the extracellular matrix structures that support tissues might be a significant cause of the growing immune dysfunction that takes place in later life. One of the more important of these changes in the extracellular matrix is the growing presence of cross-links, persistent sugary compounds produced as a byproduct of normal metabolic operations that chain together the large molecules of the extracellular matrix. In doing so these cross-links change the chemical and structural properties of the matrix and the tissue as a whole, producing results such as loss of elasticity in skin and blood vessels, which in turn contribute to a variety of age-related diseases. If cross-linking does indeed contribute to immunosenescence, the decline of the immune system with age, then that only increases the importance of ongoing research funded by the SENS Research Foundation aimed at safely breaking down this unwanted form of metabolic waste. In humans near all persistent cross-links appear to involve a single class of compound, glucosepane. So in theory there is only a single target here, needing just one drug development program to make a large difference to long-term health and longevity.

In process similar to allergy testing, small quantities of different ‘barcoded’ drugs are tested inside patient’s tumor to determine effectiveness.

Excercise is the best low cost activity you can do as part of your personal longevity strategy. Here we see data showing it can improve resistance to oxidative stress.

Researchers digging deeper into the mechanisms by which exercise produces benefits have found that it improves the resistance of blood vessels to oxidative stress. With age the presence of oxidizing molecules and oxidative modification of proteins, preventing correct function, increases for reasons that include damage to mitochondria, the power plants of the cell. Oxidative damage to molecular machinery is somewhere in the middle of the chain of cause and effect that starts with fundamental forms of damage to cells and tissues and spirals down into age-related diseases. Near all of this oxidation is repaired very quickly, the damaged molecules dismantled and recycled, but in most contexts more of it over the long term is worse than less of it.

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Continue reading “Exercise Improves Arterial Resilience to Age-Related Increases in Oxidative Stress” »