Lifeboat Foundation

A novel approach in the field of Alzheimer’s research is emerging that could potentially transform how we tackle this debilitating disease. Recent studies have revealed a paradigm shift in understanding Alzheimer’s pathology, emphasizing the importance of targeting the early-stage aggregation of the pathogenic amyloid beta (A-beta) protein, specifically focusing on its soluble oligomeric form.

Over the past three decades, conventional treatments for Alzheimer’s have largely been ineffective, primarily due to their focus on combating the fibrillar form of A-beta. However, emerging research suggests that it is the soluble oligomeric form of A-beta that poses the greatest threat to neuronal health, leading to cognitive decline and neurotoxicity.

A recent breakthrough in Alzheimer’s treatment has come from the development of an antibody capable of recognizing both oligomeric and fibrillar forms of A-beta, offering newfound hope to the field. This innovative therapy has demonstrated promising results in delaying disease progression by up to 36% in individuals with early-to-mild cognitive impairment.

Human brains preserve in diverse environments for at least 12 000 years—new research in Proceedings B this week: https://royalsocietypublishing.org/doi/10.1098/rspb.2023.

Soft tissue preservation in the geological record is relatively rare, and when an archaeologist digs a human skull out of the…

The brain is thought to be among the first human organs to decompose after death. The discovery of brains preserved in the archaeological record is therefore regarded as unusual. Although mechanisms such as dehydration, freezing, saponification, and tanning are known to allow for the preservation of the brain on short time scales in association with other soft tissues (≲4000 years), discoveries of older brains, especially in the absence of other soft tissues, are rare. Here, we collated an archive of more than 4,400 human brains preserved in the archaeological record across approximately 12 000 years, more than 1,300 of which constitute the only soft tissue preserved amongst otherwise skeletonized remains. We found that brains of this type persist on time scales exceeding those preserved by other means, which suggests an unknown mechanism may be responsible for preservation particular to the central nervous system. The untapped archive of preserved ancient brains represents an opportunity for bioarchaeological studies of human evolution, health and disease.

Continue reading “Human brains preserve in diverse environments for at least 12 000 years” »

The cyberattack on Change Healthcare last month should serve as a wake-up call for the health care industry, which needs to focus on securing its infrastructure, says Kevin Fu, a Northeastern University professor of electrical and computer engineering and cybersecurity adviser to the White House.

In this episode, Peter and Will dive into satellite technology, what it takes to create a company like Planet, and its effect on ecosystems across the world.

Will Marshall, Chairman, Co-Founder, and CEO of Planet, transitioned from a scientist at NASA to an entrepreneur, leading the company from its inception in a garage to a public entity with over 800 staff. With a background in physics and extensive experience in space technology, he has been instrumental in steering Planet towards its mission of propelling humanity towards sustainability and security, as outlined in its Public Benefit Corporation charter. Recognized for his contributions to the field, Marshall serves on the board of the Open Lunar Foundation and was honored as a Young Global Leader by the World Economic Forum.

Continue reading “Building The World’s Most Powerful Satellites w/ Will Marshall | EP #90” »

In a study published in the journal Science Advances, researchers from Peking University have unveiled a miniaturized implantable sensor capable of health monitoring without the need of transcutaneous wires, integrated circuit chips, or bulky readout equipment, thereby reducing infection risks, improving biocompatibility, and enhancing portability. The study is titled “Millimeter-scale magnetic implants paired with a fully integrated wearable device for wireless biophysical and biochemical sensing.”

Mike Dougherty American Heart Association Epidemiology and Prevention|Lifestyle and Cardiometabolic Health Scientific Sessions 2024, Abstract P192.

03/19/24 Editor’s note:

Compared to healthy volunteers, affected U.S. government personnel did not exhibit MRI-detectable brain injury or biological abnormalities that would explain symptoms.

Using advanced imaging techniques and in-depth clinical assessments, a research team at the National Institutes of Health (NIH) found no significant evidence of MRI-detectable brain injury, nor differences in most clinical measures compared to controls, among a group of federal employees who experienced anomalous health incidents (AHIs).

These incidents, including hearing noise and experiencing head pressure followed by headache, dizziness, cognitive dysfunction, and other symptoms, have been described in the news media as “Havana Syndrome” since U.S. government personnel stationed in Havana first reported the incidents. Scientists at the NIH Clinical Center conducted the research over the course of nearly five years and published their findings on March 18 in two papers in JAMA.

Google Research releases the Skin Condition Image Network (SCIN) dataset in collaboration with physicians at Stanford Med.

Designed to reflect the broad range of conditions searched for online, it’s freely available as a resource for researchers, educators, & devs → https://goo.gle/4amfMwW

#AI #medicine

Continue reading “SCIN: A new resource for representative dermatology images” »

It’s hard to imagine that a Ford F-150 Lightning out there already has nearly 100,000 miles on its odometer. Especially since they’ve only been on the roads since late May of 2022. That’s less than two years ago, yet here we have a Ford F-150 Lightning owner reporting on his electric truck with 93,000 miles on the odometer.

He’s owned this F-150 Lightning for 21 months now, so that works out to an average of 4,429 miles driven per month or about 53,000 miles yearly. And while that’s certainly a lot of driving, what’s perhaps most interesting is the battery health of the electric pickup truck.