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“Identification of these compounds means that we are one step closer to being able to molecularly diagnose dementia,” said senior author of the study, Professor Mitsuhiro Yanagida, who leads the G0 Cell Unit at OIST.


Summary: Researchers identified 33 metabolic compounds in blood samples that differed between those with dementia and cognitively healthy older adults. 7 of the metabolites were elevated in dementia patients, while 26 were at lower levels compared to samples of those without dementia. Elevating levels of those metabolites could have a neuroprotective effect against dementia.

Source: OIST

Scientists in Japan have identified metabolic compounds within the blood that are associated with dementia.

The study revealed that the levels of 33 metabolites differed in patients with dementia, compared to elderly people with no existing health conditions. Their findings, published this week in PNAS, could one day aid diagnosis and treatment of dementia.

“We think that this indicates that gut bacteria and fungi influence anti-tumor immune responses in many, if not all, types of cancer.”


Cedars-Sinai Cancer researchers have discovered that intestinal microorganisms help regulate anti-tumor immune responses to radiation treatments, and that fungi and bacteria have opposing effects on those responses. The study, conducted in laboratory mice 0 illuminates a path toward improving the effectiveness of radiation and immune-based treatments for patients with melanoma, breast and many other cancers.

The study, published on Aug. 13 in the peer-reviewed journal Cancer Cell, builds on prior studies that focused on the role of intestinal bacteria in influencing immune responses to chemotherapy and immunotherapy. Here the investigators sought to determine what role both bacteria and fungi in the gut might play in the response to radiation therapy.

Trillions of microorganisms live in normal human intestines. These so-called commensal microorganisms are “friendly” bacteria and fungi that help process nutrients and play key roles in regulating the immune system in everything from infections to allergies. The research team found that reducing levels of commensal fungi in the intestines enhanced the anti-tumor immune response in the mice following radiation therapy. Conversely, they showed that depletion of commensal bacteria reduced the anti-tumor response.

Hwang and colleagues lay out their platform, which could one day be integrated not only into dental implants but other technologies, such as joint replacements, as well.


More than 3 million people in America have dental implants, used to replace a tooth lost to decay, gum disease, or injury. Implants represent a leap of progress over dentures or bridges, fitting much more securely and designed to last 20 years or more.

But often implants fall short of that expectation, instead needing replacement in five to 10 years due to local inflammation or gum disease, necessitating a repeat of a costly and invasive procedure for patients.

“We wanted to address this issue, and so we came up with an innovative new ,” says Geelsu Hwang, an assistant professor in the University of Pennsylvania School of Dental Medicine, who has a background in engineering that he brings to his research on oral health issues.

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The full post: https://www.thebioneer.com/future-of-fitness-2/(opens in a new tab)

This post explores the possible future of health and fitness! I made this into a pseudo-science-fiction narrative, just for the fun of it! This is, however, all just my own opinion and speculation! Very biased, and just a bit of fun.

Also, I’m not saying even I think all of this *will* happen… But most of it could!

A few of the predictions for the future of health and fitness, as discussed here:

Info for those who may need it.


The Editors of BMC Cancer and BMC Medicine invite of submissions to our ‘Targeted Therapy’ cross journal collection. Guest edited by Prof. Min Li (University of Oklahoma Health Sciences Center, USA) and Dr. Yanis Boumber (The Northwestern University, USA).

We advise to submit by 1st August 2021 if you would like your manuscript to be ready for the launch date.

A new Yale study provides important insights into breakthrough COVID-19 cases — instances where fully vaccinated individuals are infected by SARS-CoV-2 — and who is particularly vulnerable to serious illness.

In a study of hospitalized patients in the Yale New Haven Health System, researchers identified 969 individuals who tested positive for the SARS-CoV-2 infection during a 14-week period between March and July 2021. Of that group, 54 were fully vaccinated.

“These cases are extremely rare, but they are becoming more frequent as variants emerge and more time passes since patients are vaccinated,” said Hyung Chun, associate professor of medicine (cardiology) at Yale and senior author of the study published Sept. 7 in Lancet Infectious Diseases.

Many benefits have already been linked to the Mediterranean diet, and additional studies continue to examine its health effects that reveal other reasons to follow it.

This diet, based on a menu that contains whole grains, healthy fats, a large variety of fruits and vegetables and is relatively low in dairy products and red meat, is considered one of the healthiest diet lifestyles to keep.

Past research already established this diet’s contribution to prolonging life expectancy, as it reduces the risk of cardiovascular disease and also certain types of cancer, diabetes, dementia and more. Now, a new study finds that the Mediterranean diet is also beneficial for sexual function, improves blood circulation in general and also specifically for the penis, and is associated with higher levels of testosterone.


A new study presents interesting findings on the link between the Mediterranean diet and improved sexual function, especially for men of a certain age.

“I think this virus is here to stay with us and it will evolve like influenza pandemic viruses, it will evolve to become one of the other viruses that affects us,” Dr. Mike Ryan, executive director of the World Health Organization’s Health Emergencies Program, said at a press briefing.


Covid-19 could become endemic like the flu and circulate in the population at low levels.

Circa 23 March 2020


The ways in which a neoplastic cell arises and evades the immune system is the result of a departure from the systems biology that governs health. Understanding this biology requires methods that can resolve the heterogeneity of cell types, determine their states, whether they are activated (e.g., HLA-DR high) or suppressed (e.g., PD-1 high), and map their relationships or distances to one another. MIBI provides single cell resolution and sensitivity to phenotypically characterize the complex tissue environments including the TME. Executed similarly to IHC yet with the capability to profile 40+ markers simultaneously, MIBI is broadly applicable to a wide range of analyses performed in anatomic pathology including cell classification, spatial characterization, and assessment of marker expression. The MIBIscope produces data (multilayer TIFF files) that can be accessed by many analysis platforms currently available, such as those found in commercial software packages such as Fiji, Halo, and VisioPharm or freely available bioinformatic packages developed with open-source programming languages (e.g., R, Python).

All tumor types were stained, imaged, and analyzed using a single staining panel and standardized protocol. The workflow is flexible such that slides can be stained in batches and stored until imaged on the MIBIscope. Stained slides are typically stored under vacuum but protection from light is not necessary as the labels are stable metal isotopes rather than light-sensitive fluorophores. Once imaged it is possible to reimage the tissue as only a modest depth of the tissue is sputtered and analyzed during a single acquisition [16]. One limitation of the current project performed with an earlier version of the MIBIScope is the relatively small FOV size (500 μm by 500 μm) needed for images with 0.5 µm resolution. The current MIBIScope enables FOVs of 800 μm by 800 μm to be imaged in 70 min at fine resolution (650 nm). The resolution can be controlled at the instrument and acquisition at a slightly lower resolution than used in this study (1 μm) can be performed in 17 min. The 800 μm FOV captures 82% of a 1 mm TMA core. FOVs across cores of a TMA can be selected and then imaged in a single run. For whole sections it is possible to acquire adjacent images and stitch the images together using techniques commonly performed with other imaging technologies [22]. The need for tiling is particularly acute for imaging brain sections where multiple FOVs are collected to generate a larger image. Together with researchers at Stanford University, we are currently developing tiling methods to map large regions of brain tissue which will be described in a future publication. Because MIBI is still an early technology, the underlying methods for each stage of the processing pipeline are constantly evolving and improving, not just for accuracy but for generality. While the methods themselves are evolving, the pipeline tasks, at a high level, such as mass calibration, filtering, etc., are defined and have been automated through the MIBI/O software, and, as importantly, allows for appropriate user input when necessary. As more data becomes available, and the user base of MIBI grows, data processing should become more standardized.

The immediate utility of MIBI will be for understanding the biological mechanisms present in disease microenvironments. The results demonstrate the ability to detect a range of marker expression across many tumor types. The images can be segmented to define cell boundaries and then the expression of phenotypic markers used to classify cell instances into their cell class, such as proliferating tumor cells or nonproliferating tumor cells and various immune cells. Additional markers have been used on other sample sets to further define myeloid cell subsets, B cell subsets and stromal elements including vascular endothelial cells. This study also demonstrated the possibilities for calculating distances between different cell subsets including tumor and immune cells in addition to PD-1 and PD-L1 expressing immune cell subsets.

A genomic analysis of lung cancer in people with no history of smoking has found that a majority of these tumors arise from the accumulation of mutations caused by natural processes in the body. This study was conducted by an international team led by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), and describes for the first time three molecular subtypes of lung cancer in people who have never smoked.

These insights will help unlock the mystery of how lung cancer arises in people who have no history of smoking and may guide the development of more precise clinical treatments. The findings were published September 6 2021, in Nature Genetics.

“What we’re seeing is that there are different subtypes of lung cancer in never smokers that have distinct molecular characteristics and evolutionary processes,” said epidemiologist Maria Teresa Landi, M.D., Ph.D., of the Integrative Tumor Epidemiology Branch in NCI’s Division of Cancer Epidemiology and Genetics, who led the study, which was done in collaboration with researchers at the National Institute of Environmental Health Sciences, another part of NIH, and other institutions. “In the future we may be able to have different treatments based on these subtypes.”