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Category: health – Page 196

Genomes from 240 mammalian species reveal what makes the human genome unique

Over the past 100 million years, mammals have adapted to nearly every environment on Earth. Scientists with the Zoonomia Project have been cataloging the diversity in mammalian genomes by comparing DNA sequences from 240 species that exist today, from the aardvark and the African savanna elephant to the yellow-spotted rock hyrax and the zebu.

This week, in several papers in a special issue of Science, the Zoonomia team has demonstrated how can not only shed light on how certain species achieve extraordinary feats, but also help scientists better understand the parts of our genome that are functional and how they might influence health and disease.

In the new studies, the researchers identified regions of the genomes, sometimes just single letters of DNA, that are most conserved, or unchanged, across mammalian species and millions of years of evolution—regions that are likely biologically important. They also found part of the genetic basis for uncommon mammalian traits such as the ability to hibernate or sniff out faint scents from miles away. And they pinpointed species that may be particularly susceptible to extinction, as well as genetic variants that are more likely to play causal roles in rare and common human diseases.

Polybot: AI and robotics unite to revolutionize polymer electronics research

A team of researchers at the U.S. Department of Energy’s Argonne National Laboratory has developed a new scientific tool called Polybot that combines artificial intelligence with robotics. This tool is set to revolutionize polymer electronics research by speeding up the discovery process of materials with multiple applications, from wearable biomedical devices to better batteries, according to a release.

Polymer electronics are the future of flexible electronics. They are efficient and sustainable, used to monitor health and treat certain diseases, among other things. However, the current methods used to prepare these polymers for electronics can take years of intense labor. To achieve targeted performance, there are an overwhelming number of potential tweaks, from spiking the fabrication recipe with different formulations to varying the processing conditions.

Opinion letter from Ray Kurzweil on request for 6 month delay on large language models that go beyond GPT-4 « Kurzweil

Kurzweil says NO, on AI pause non sense.

By Ray Kurzweil April 2023

Regarding the Open Letter to “pause” research on AI “more powerful than GPT-4,” this criterion is too vague to be practical. And the proposal faces a serious coordination problem: those that agree to a pause may fall far behind corporations or nations that disagree. There are tremendous benefits to advancing AI in critical fields such as medicine and health, education, pursuit of renewable energy sources to replace fossil fuels, and scores of other fields. I didn’t sign, because I believe we can address the signers’ safety concerns in a more tailored way that doesn’t compromise these vital lines of research.

If Candida auris is drug-resistant, how do you kill it?

(NEXSTAR) – A deadly fungus spreading in more than half of U.S. states is so concerning in part because of the way it has evolved to be resistant to both antimicrobial cleaning products and anti-fungal drugs, the Centers for Disease Control and Prevention recently warned.

The fungus, Candida auris or C. auris, has mainly spread in health care settings, like hospitals and nursing homes. Counterintuitively, because hospitals are disinfected so frequently, they can be the birthplace of bacteria or fungus that are resistant to cleaning products and to treatments.

Childhood abuse and biological sex linked to epigenetic changes in functional neurological disorder

Functional movement/conversion disorder (FMD), part of the spectrum of Functional Neurological Disorder (FND), is a neuropsychiatric condition marked by a range of neurological symptoms, including tremors, muscular spasms and cognitive difficulties. Despite being the second-most common cause of referrals to neurology outpatient clinics after headache, scientists have struggled to pin down the disorder’s root cause. Female sex and a history of childhood trauma are factors associated with higher risk of developing FMD, but it’s been unclear why.

A new study from investigators of the Brigham and Women’s Hospital, in collaboration with researchers at the National Institute of Neurological Disorders and Stroke, demonstrated that FMD is characterized by epigenetic changes, and that women and childhood abuse survivors with FMD have different epigenetic profiles linked to this condition. Their study, which examined the genomes of over 100 individuals and was recently published in Progress in Neuro-Psychopharmacology and Biological Psychiatry, is the first to demonstrate the occurrence of epigenetic changes in FMD.

“This study finally takes FMD out of a cloud of confusion and provides a neuroscientifically grounded explanation for why childhood trauma and female sex are associated with this disorder,” said lead author Primavera A. Spagnolo, MD, Ph.D., scientific director of the Mary Horrigan Connors Center for Women’s Health and Gender Biology and assistant professor of psychiatry at HMS.

What happens when we read? Decoding the brain’s dual networks

The brain’s processing of reading is fascinating.

Reading is a fascinating process that engages many regions of our brain. We all know it’s an essential skill, but did you know that reading is like weightlifting for our minds? The more we read, the stronger our neural connections become, and the better we get at it. But what happens in our brains when we read? Scientists have been trying to answer this question for years, and a new study has finally shed some light on the matter.

A groundbreaking study led by neuroscientist Oscar Woolnough from the University of Texas Health Science Center at Houston shed new light on how our brains process language. According to the research, two distinct brain networks get activated while reading.

Hidden Linkages: Scientists Find Mind-Body Connection Is Built Into Brain

Findings point to brain areas that integrate planning, purpose, physiology, behavior, and movement.

Calm body, calm mind, say the practitioners of mindfulness. A new study by researchers at Washington University School of Medicine in St. Louis indicates that the idea that the body and mind are inextricably intertwined is more than just an abstraction. The study shows that parts of the brain area that control movement are plugged into networks involved in thinking and planning, and in control of involuntary bodily functions such as blood pressure and heartbeat. The findings represent a literal linkage of body and mind in the very structure of the brain.

The research, published on April 19 in the journal Nature, could help explain some baffling phenomena, such as why anxiety makes some people want to pace back and forth; why stimulating the vagus nerve, which regulates internal organ functions such as digestion and heart rate, may alleviate depression; and why people who exercise regularly report a more positive outlook on life.

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