Lifeboat Foundation

Emerging and reemerging infections present an ever-increasing challenge to global health. Here, we report a nanoparticle-enabled smartphone (NES) system for rapid and sensitive virus detection. The virus is captured on a microchip and labeled with specifically designed platinum nanoprobes to induce gas bubble formation in the presence of hydrogen peroxide. The formed bubbles are controlled to make distinct visual patterns, allowing simple and sensitive virus detection using a convolutional neural network (CNN)-enabled smartphone system and without using any optical hardware smartphone attachment. We evaluated the developed CNN-NES for testing viruses such as hepatitis B virus (HBV), HCV, and Zika virus (ZIKV). The CNN-NES was tested with 134 ZIKV-and HBV-spiked and ZIKV-and HCV-infected patient plasma/serum samples. The sensitivity of the system in qualitatively detecting viral-infected samples with a clinically relevant virus concentration threshold of 250 copies/ml was 98.97% with a confidence interval of 94.39 to 99.97%.

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Smartphone systems can also benefit from the recent unprecedented advancements in nanotechnology to develop diagnostic approaches. Catalysis can be considered as one of the popular applications of nanoparticles because of their large surface-to-volume ratio and high surface energy (11–16). So far, numerous diagnostic platforms for cancer and infectious diseases have been developed by substituting enzymes, such as catalase, oxidase, and peroxidase with nanoparticle structures (17–20). Here, we adopted the intrinsic catalytic properties of platinum nanoparticles (PtNPs) for gas bubble formation to detect viruses on-chip using a convolutional neural network (CNN)–enabled smartphone system.

Johnson & Johnson said Thursday that late-stage clinical trials for its coronavirus vaccine are now fully enrolled, and expects to release initial data on the shot’s effectiveness by the end of January.

The pharmaceutical company’s single-dose vaccine is in Phase 3 clinical trials that are now fully enrolled, and is already being reviewed by Health Canada.

Mice, fruit flies and dogs are common creatures of laboratories across the country, valuable to researchers for their genetic proximity to humans. But what about lampreys?

A new Yale School of Public Health study has enlisted this unlikely and slimy ally in the fight against cancer.

By carefully tracing the evolution of a select number of cancer-causing genes in a variety of species, the researchers evaluated which animals are—and are not—effective in gauging how an analog of those genes in humans can lead to cancer. What they found is surprising: jawless fish such as lampreys share significant similarities in these certain genes compared to humans, while fruit flies do not. Their findings, published in the journal Genome Biology and Evolution, will help molecular biologists and other scientists as they work to find potential cures to certain cancers, such as lymphoma.

Sony Corp. has created one of the hottest gadgets of the year in the PlayStation 5, but its launch has been marred by scalpers who are buying up scarce supplies and threatening the long-term health of the company’s most important product.

An epidemiologist who helped to tie the 2012 outbreak of Middle East respiratory syndrome (MERS) to camels; a food-safety officer who studies how pathogens spread in markets; and a veterinarian who found evidence linking the 2014 West Africa Ebola outbreak to bats roosting in a hollow tree. These researchers are among the team that the World Health Organization (WHO) has assembled to investigate the origins of the coronavirus pandemic.

Ten researchers with expertise in virology, public health and animals will seek to answer this key question.

CSL’s Systems and Networking Research Group (SyNRG) is defining a new sub-area of mobile technology that they call “earable computing.” The team believes that earphones will be the next significant milestone in wearable devices, and that new hardware, software, and apps will all run on this platform.

“The leap from today’s earphones to ‘earables’ would mimic the transformation that we had seen from basic phones to smartphones,” said Romit Roy Choudhury, professor in electrical and computer engineering (ECE). “Today’s smartphones are hardly a calling device anymore, much like how tomorrow’s earables will hardly be a smartphone accessory.”

Instead, the group believes tomorrow’s earphones will continuously sense human behavior, run acoustic augmented reality, have Alexa and Siri whisper just-in-time information, track user motion and health, and offer seamless security, among many other capabilities.

In this important conversation on health, David Gornoski sits down with Jim O’Neill, CEO of the SENS Research Foundation and former managing director of Thiel Capital. How do we effectively fight viruses such as COVID-19? O’Neill brings attention to the urgency of strengthening our immune systems. Why should we look into anti-aging? Anti-aging research, O’Neill says, looks into the possibility of targeting senescent cells where many diseases take hold. How soon can we see the results of this research? Given our societal norms, is overcoming death through scientific means something that we should look into? How does Christian teaching relate to the idea of overcoming death in time and space?

Visit SENS Research Foundation here:
https://www.sens.org/
Follow Jim O’Neill on Twitter here:
https://twitter.com/regardthefrost/

Continue reading “Technologist Jim O’Neill Makes the Case for Dramatic Anti-Aging Medicine” »

I think I want non-gene hacked pigs for my supper. 😃

For the second time ever, the U.S. Food and Drug Administration (FDA) approved a gene-hacked animal for human consumption.

In this case, it’s the GalSafe pig, CNN reports, a genetically modified swine that’s safe even for people with allergies to eat. All in all, it’s a fresh sign that genetically-altered animals and sophisticated gene-hacking technology are now becoming commercially viable and entering the mainstream.

Continue reading “FDA Approves Gene-Hacked Pigs for Human Consumption” »

Is ADHD actually a superpower that goes out of control from time to time? Can it be turned into an advantage?

Unclench. Mary is just an urban legend—a case example of how people with Attention-Deficit/Hyperactivity Disorder can hyperfocus on a task for hours, losing all awareness of their surroundings. Hers is a story that people in the ADHD community tell themselves so we will feel less alone.

“We all hate the name ADHD,” says Elaine Taylor-Klaus, cofounder of Atlanta consultancy group ImpactADHD. Because the word “deficit” is in the name, many incorrectly assume having ADHD means you can’t pay attention. Instead, ADHDers often pay more attention to certain tasks than we should. It’s called hyperfocus.

Continue reading “People With ADHD Can Actually Focus So Hard it’s Scary” »