In a preclinical study, researchers led by City of Hope have discovered that a type of immune cell in the human body, known to be important for allergy and other immune responses, can also attack cancer. The cells, called human type 2 innate lymphoid cells (ILC2s), can be expanded outside of the body and applied in larger numbers to overpower a tumor’s defenses and eliminate malignant cells in mouse models with cancer.

The findings are published in Cell in an article titled, “Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death.”

“The City of Hope team has identified human ILC2 cells as a new member of the cell family capable of directly killing all types of cancers, including blood cancers and solid tumors,” said Jianhua Yu, PhD, a professor in the department of hematology and hematopoietic cell transplantation at City of Hope and the study’s senior author. “In the future, these cells could be manufactured, preserved by freezing, and then administered to patients. Unlike T cell-based therapies, such as CAR T cells, which necessitate using the patient’s own cells due to their specific characteristics, ILC2s might be sourced from healthy donors, presenting a distinct potential therapeutic approach as an allogeneic and ‘off-the-shelf’ product.”

“The bottom-line finding is that cannabis before exercise seems to increase positive mood and enjoyment during exercise, whether you use THC or CBD. But THC products specifically may make exercise feel more effortful,” said Dr. Laurel Gibson.

How does cannabis influence workouts? Does it serve as a performance enhancer or in other ways? This is what a recent study published in Sports Medicine hopes to address, as a team of researchers from the University of Colorado Boulder (CU Boulder) and the University of Colorado Anschutz Medical Campus investigated how cannabis influences exercise workouts and regimens, specifically pertaining to the exercise performance. This study comes almost a decade since Colorado legalized the sale of recreational marijuana and holds the potential to help researchers and the public better understand cannabis’ role in our everyday lives.

For the first-of-its-kind study that started in 2021, the researchers recruited 42 participants who were consistent cannabis users ages 21 to 39 to ascertain their responses to exercise after using cannabis and in a controlled laboratory setting. In the end, the participants reported increased enjoyment and “runner’s high” characteristics while also reporting greater levels of exertion during their exercise regimen. Additionally, the participants reported the following when the researchers asked them why they combine cannabis with their workout routines: 90.5 percent said it increases enjoyment, 69 percent said it reduces pain, 59.5 percent said it increases focus, 57.1 percent said it increases motivation, 45.2 percent stated they perceived that it speeds up time, and 28.6 percent said it improves their performance.