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In a recent study led by Ravi Salgia, M.D., Ph.D., the Arthur & Rosalie Kaplan Chair in Medical Oncology, a team of researchers from City of Hope, one of the largest cancer research and treatment organizations in the United States, and other institutions found that nongenetic mechanisms are important in lung cancer patients who develop a resistance to one cancer therapy. Their findings were published in the October 13 issue of the journal Science Advances.

The team’s study explored resistance to the anti-cancer medication sotorasib in patients with non-small cell lung cancer (NSCLC). Sotorasib inhibits a specific mutation of a protein, KRAS G12C, that causes unchecked cell growth.

The researchers’ findings suggest that, initially, most tumor cells are sensitive to sotorasib. But some cells can become tolerant to therapeutic treatment without resorting to genetic mutations or alterations by manipulating the KRAS-sotorasib interaction network. Furthermore, they found that if sotorasib treatment is withheld, the tumor cells revert to becoming sensitive again, implying that the phenomenon is reversible and thus is driven by nongenetic mechanisms.

Researchers at Tokyo Tech have demonstrated that in-cell engineering is an effective method for creating functional protein crystals with promising catalytic properties. By harnessing genetically altered bacteria as a green synthesis platform, the researchers produced hybrid solid catalysts for artificial photosynthesis.

Photosynthesis is how plants and some microorganisms use sunlight to synthesize carbohydrates from carbon dioxide and water.

According to this information covid 19 sars is a chimeric virus that evolves with other genetic material which gives us clues for a proper antidote. Also it shows why it is so dangerous.

Ben Hu denies he was sick in late 2019, or that his coronavirus work led to COVID-19, and newly declassified U.S. intelligence doesn’t substantiate allegations against him.

I dont really care where it comes from but we need Crispr tec to be where any alteration we do want causes Zero un intended alterations any where else 100% of the time, aim for by 2030–2035 window.

A diverse set of species, from snails to algae to amoebas, make programmable DNA-cutting enzymes called Fanzors—and a new study from scientists at MIT’s McGovern Institute for Brain Research has identified thousands of them. Fanzors are RNA-guided enzymes that can be programmed to cut DNA at specific sites, much like the bacterial enzymes that power the widely used gene-editing system known as CRISPR. The newly recognized diversity of natural Fanzor enzymes, reported Sept. 27 in the journal Science Advances, gives scientists an extensive set of programmable enzymes that might be adapted into new tools for research or medicine.

“RNA-guided biology is what lets you make programmable tools that are really easy to use. So the more we can find, the better,” says McGovern Fellow Omar Abudayyeh, who led the research with McGovern Fellow Jonathan Gootenberg.

Continue reading “Thousands of programmable DNA-cutters found in algae, snails, and other organisms” »

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Hello and welcome! My name is Anton and in this video, we will talk about an invention of a DNA bio computer.
Links:
https://www.nature.com/articles/s41586-023-06484-9
https://www.washington.edu/news/2016/04/07/uw-team-stores-di…perfectly/
Other videos:
https://youtu.be/x3jiY8rZAZs.
https://youtu.be/JGWbVENukKc.

#dna #biocomputer #genetics.

Continue reading “So…Biocomputers Made Out of DNA Circuits May Be a Thing Now” »

A key genetic mutation—harmful in humans—may have opened the sky to bats.

An Australian first biobank will be established to improve and discover new treatments for children with genetic muscle diseases.

The National Muscle Disease Bio-databank, co-led by Murdoch Children’s Research Institute, Monash University and The Alfred, will advance research into our understanding of why children develop genetic muscle diseases.

These diseases, spanning dystrophies and myopathies, are characterised by severe muscle weakness, usually from infancy, that can impact swallowing, breathing and lead to eye problems and learning difficulties.

Continue reading “Biobank aims to discover new treatments for children with genetic muscle diseases” »

When it comes to human longevity, you might envision nanobots helping our bodies operate more efficiently. But our bodies are biological machines in their own right, evolved to handle any situation in the real world from illness to cold to hunger. Our bodies heal themselves, and they can be programmed to do so if we understood that language better.

This video talks about DNA and genes, and the epigenetic mechanisms that read that information. The epigenetic clock is one way to measure the age of cells, and this can be reversed with current technologies. We discuss experiments by David Sinclair, which made blind mice see again, and experiments by Greg Fahy, which regenerated the immune system of humans and reset their cellular age by 2 years.

Continue reading “Unlocking immortality: the science of reversing aging” »

Scientists testing a new method of sequencing single cells have unexpectedly changed our understanding of the rules of genetics.

The genome of a protist has revealed a seemingly unique divergence in the DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).