Lifeboat Foundation

The strength of genome-wide association studies (GWAS) lies in their ability to identify new disease biomarkers through large-scale genomic comparisons of afflicted individuals and unaffected controls. Now, using this powerful technique, an international collaboration of researchers has identified five new gene regions that increase a woman’s risk of developing endometrial cancer—one of the most common cancers to affect women—taking the number of known gene regions associated with the disease to nine.

Endometrial cancer affects the lining of the uterus, typically presenting as an adenocarcinoma. Endometrial cancer is the sixth most common cancer in women worldwide and is the most common cancer of the female reproductive tract in developed countries, with over 320,000 new cases diagnosed in 2012.

Investigators at the University of Cambridge, Oxford University, and QIMR Berghofer Medical Research Institute in Brisbane studied the DNA of over 7000 women with endometrial cancer and 37,000 women without cancer to identify genetic variants that affected a woman’s risk of developing the disease.

Continue reading “Endometrial Cancer Genetic Risk Factors Double” »

The likelihood of giving birth to non-identical twins run in the families, suggests a new study conducted by a team of scientists. The team based their conclusion on the identification of two genetic variants in women who give birth to twins.

A number of factors have previously been linked to why some women give birth to non-identical twins. However, no study ever characterized the properties of the genes the contribute to this outcome.

The latest study looks at the genetic makeup of the mother and explains how mother’s genes can lead to the birth of non-identical twins. During the study, the research team specifically compared the genomes of the non-identical twins’ mothers to look for any common genetic variants between them.

Continue reading “Non-Identical Twins Run In Families: Scientists Find Common Genes” »

Very cool!

As we age, tiny blood vessels in the brain stiffen and sometimes rupture, causing “microbleeds.” This damage has been associated with neurodegenerative diseases and cognitive decline, but whether the brain can naturally repair itself beyond growing new blood-vessel tissue has been unknown. A zebrafish study published on May 3 in Immunity describes for the first time how white blood cells called macrophages can grab the broken ends of a blood vessel and stick them back together.

“Microbleeding occurs very often in the human brain, particularly in elderly people,” says Lingfei Luo, a developmental geneticist at Southwest University in China. “We believe that this macrophage behavior is the major cellular mechanism to repair ruptures of blood vessels and avoid microbleeding in the brain.”

To simulate a human brain microbleed, Luo and his colleagues shot lasers into the brains of live zebrafish to rupture small blood vessels, creating a clean split in the tissue with two broken ends. Then, the researchers used a specialized microscope to watch what happened next.

The article states that European royal houses are all closely related. Well in humanities history it’s thought that over 80% of all marriages were between second cousins or closer. While until the industrial revolution the nobility would have been the only demographic who could travel further than as far as you can walk from your home and back in a day. So until the industrial revolution the nobility were probably the most genetically diverse demographic.

‘Virgin births’ happen in nature more than we thought, says Frank Swain, so what’s stopping human beings from doing the same?

When tweaking its architecture, the adult brain works like a sculptor—starting with more than it needs so it can carve away the excess to achieve the perfect design. That’s the conclusion of a new study that tracked developing cells in an adult mouse brain in real time.

New brain cells began with a period of overgrowth, sending out a plethora of neuronal branches, before the brain pruned back the connections. The observation, described May 2, 2016 in Nature Neuroscience, suggests that new cells in the adult brain have more in common with those in the embryonic brain than scientists previously thought and could have implications for understanding diseases including autism, intellectual disabilities and schizophrenia.

“We were surprised by the extent of the pruning we saw,” says senior author Rusty Gage, a professor in Salk’s Laboratory of Genetics and holder of the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease.

A study performed at IRB Barcelona offers an explanation as to why the genetic code stopped growing 3,000 million years ago. This is attributed to the structure of transfer RNAs—the key molecules in the translation of genes into proteins. The genetic code is limited to 20 amino acids—the building blocks of proteins—the maximum number that prevents systematic mutations, which are fatal for life. The discovery could have applications in synthetic biology.

Nature is constantly evolving—its limits determined only by variations that threaten the viability of species. Research into the origin and expansion of the genetic code are fundamental to explain the evolution of life. In Science Advances, a team of biologists specialised in this field explain a limitation that put the brakes on the further development of the genetic code, which is the universal set of rules that all organisms on Earth use to translate genetic sequences of nucleic acids (DNA and RNA) into the amino acid sequences that comprise the proteins that undertake cell functions.

Headed by ICREA researcher Lluís Ribas de Pouplana at the Institute for Research in Biomedicine (IRB Barcelona) and in collaboration with Fyodor A. Kondrashov, at the Centre for Genomic Regulation (CRG) and Modesto Orozco, from IRB Barcelona, the team of scientists has demonstrated that the genetic code evolved to include a maximum of 20 amino acids and that it was unable to grow further because of a functional limitation of transfer RNAs—the molecules that serve as interpreters between the language of genes and that of proteins. This halt in the increase in the complexity of life happened more than 3,000 million years ago, before the separate evolution of bacteria, eukaryotes and archaebacteria, as all organisms use the same code to produce proteins from genetic information.

Continue reading “Discovery of a fundamental limit to the evolution of the genetic code” »

Scientists at the Gladstone Institutes have used chemicals to transform skin cells into heart cells and brain cells, instead of adding external genes — making this accomplishment a breakthrough, according to the scientists.

Continue reading “Scientists turn skin cells into heart and brain cells using only drugs — no stem cells required” »

A genetic therapy has improved the vision of patients who would otherwise have gone blind.

A clinical study by British scientists has shown that the improvement is long-lasting and so the therapy is suitable to be offered as a treatment.

The researchers will apply for approval to begin trials to treat more common forms of blindness next year.

The results pointed to MC1R, known previously as a gene for red hair and freckles.

Scientists say they have made a leap in knowing why some people retain their youthful looks while others age badly.

The new study is the first time that “a gene has been found that explains, in part, why some people look older and others younger for their age”, Manfred Kayser, a professor of forensic molecular genetics at Erasmus MC University Medical Center Rotterdam in the Netherlands and a senior author on the study, said in a statement.

Continue reading “Long in the tooth, or just a redhead?” »