San Diego-based biotech startup Rejuvenate Bio is making a major claim that’ll likely draw heated scrutiny from the scientific community: that its technology was able to significantly extend the lives of elderly mice.
In tests, the company found that treated mice lived on for another 18 weeks on average. Those who were not treated in a control group only lived for another nine weeks. Overall, they say, the gene hacked mice lived roughly seven percent longer overall.
An international study 13 years in the making demonstrates for the first time that degradation in the way DNA is organized and regulated — known as epigenetics — can drive aging in an organism, independently of changes to the genetic code itself.
Summary: Researchers identify the role the Pig-Q gene plays in sleep regulation. Mutations of the Pig-Q gene increase sleep.
Source: Texas A&M
A research effort involving researchers from Texas A&M University, the Perelman School of Medicine at the University of Pennsylvania and Children’s Hospital of Philadelphia (CHOP) has used human genomics to identify a new genetic pathway involved in regulating sleep from fruit flies to humans—a novel insight that could pave the way for new treatments for insomnia and other sleep-related disorders.
Queen ants live far longer than genetically identical workers. Researchers are learning what their longevity secrets could mean for aging in other species.
Dr Vittorio Sebastiano presents about aging and reprogramming and answers questions from audience in this clip. He specifies short Reprogramming does not impact cellular Identity but Impact cellular age and cellular health.
Dr. Vittorio Sebastiano is an Assistant Professor in the Department of Obstetrics and Gynecology at Stanford School of Medicine. His lab has established a new technology named ERA (Epigenetic Reprogramming of Aging), which repurposes the conceptual idea of reprogramming, with the goal to promote epigenetic rejuvenation of adult cells leaving their identity untouched. This new technology was patented and is being implemented by Turn Biotechnologies, of which Dr. Sebastiano is co-founder and Chair of the Scientific Advisory Board.
In 2009, Dr. Sebastiano completed a postdoctoral fellowship at the laboratory of Dr. Marius Wernig at Stanford University, where he implemented the newly discovered iPSC technology and was among the first to demonstrate that iPSCs can be efficiently derived, genetically modified, and implemented for cell therapy in genetic diseases (Sebastiano et al., 2014, Science Translational Medicine). Dr. Sebastiano completed his undergraduate and graduate studies at the University of Pavia, Italy, where he studied murine germ cells and preimplantation development and where he pioneered cellular reprogramming by Somatic Cell Nuclear Transfer. He joined the Max Planck Institute for Molecular Biomedicine as a postdoctoral fellow under the mentorship of Dr. Hans Robert Schöler, where he continued his research on cellular reprograming, germ cells biology, and embryonic development.
DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes.
The finding that these “hidden” memories can be accessed once more, at least in mice, throws up a world of intriguing possibilities.
Neuroscientist Robbert Havekes and his team at the University of Groningen found that learning while sleep-deprived does not result in memory loss; rather, it is more difficult to recall.
“We previously focused on finding ways to support memory processes during a sleep deprivation episode,” says Havekes.
Artisteer/iStock.
Havekes and the team used optogenetic techniques and the human-approved asthma medicine roflumilast to find a means to make this “hidden knowledge” accessible once more days after researching while sleep-deprived.
Investigators at Cedars-Sinai have created a unique and detailed molecular profile of endometriosis to help improve therapeutic options for the millions of women suffering from the disease.
The study is published today in the journal Nature Genetics.
“Endometriosis has been an understudied disease in part because of limited cellular data that has hindered the development of effective treatments. In this study we applied a new technology called single-cell genomics, which allowed us to profile the many different cell types contributing to the disease,” said Kate Lawrenson, Ph.D., an associate professor in the Department of Obstetrics and Gynecology at Cedars-Sinai, and co-senior and corresponding author of the study.
Researchers have used fruit flies to decipher an unexplained connection between Alzheimer’s disease and a genetic variation, revealing that it causes neurons to die.
The findings from the Walter and Eliza Hall Institute (WEHI)-led team uncover a possible cause of neurodegeneration in the early stages of Alzheimer’s disease and open the door for the future development of new treatments for cognitive diseases.
The study, “An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration,” with collaborators from Australian National University, is published in Scientific Reports.
