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A spatial in situ hybridization approach to T cell clonotype analysis using T cell receptor variable gene probes

Ly et al. developed a spatial in situ hybridization approach using TCR variable-gene probes to map T cell clonality and phenotype at single-cell resolution. By applying this technique to autoimmune kidney biopsies, they found that expanded T cells form localized clusters near antigen-presenting cells, consistent with local activation and proliferation.

Microsoft Looking To Save As Much As $600 Million By Swapping GPT And Claude For China’s Kimi K3 In Copilot, Risking A Rap On The Knuckles From The Trump Administration

Microsoft is adding Kimi K3 to its Azure cloud services, while its engineers continue to evaluate the model for a deployment within Copilot.

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