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The Immune Chain Reaction That Raises Colon Cancer Risk in IBD

A hidden immune cascade linking the gut and bone marrow may explain how IBD turns inflammation into colon cancer.

Scientists at Weill Cornell Medicine have identified a complex immune process in the gut that may help explain why people with inflammatory bowel disease (IBD) face a much higher risk of colorectal cancer. The preclinical study shows how a specific immune signal can trigger a wave of white blood cells from the bone marrow into the gut, creating conditions that support tumor growth. The findings also suggest new approaches for detecting disease activity, tracking risk, and developing future treatments.

The role of TL1A in gut inflammation.

Scientists Create “Off-the-Shelf” Cartilage That Safely Guides the Body To Regrow Bone

A new study shows that engineered, cell-free cartilage can safely support bone regeneration without provoking immune rejection. New research suggests it may be possible to repair major bone damage using a tissue implant that contains no living cells. By relying on the body’s own repair machine

Detection of THC Impairment Using Functional Near-Infrared Spectroscopy

Among adults receiving oral THC, portable fNIRS scans detected impairment with higher accuracy and fewer false positives than field sobriety tests, supporting fNIRS as a more objective approach for cannabis impairment detection.


This crossover trial compares the accuracy of resting-state functional near-infrared spectroscopy vs standard field sobriety testing to detect ∆9-tetrahydrocannabinol (THC) impairment among adults who use cannabis.

Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens

Now online! Structural and functional analyses elucidate the mechanisms by which two ATP-independent RNA chaperones, Ro60 and La, recognize and unfold misfolded RNAs. Diverse noncoding RNAs are associated with this chaperone machine, supporting a wide-ranging role in maintaining RNA homeostasis.

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