The mystery of collapsing bubbles, impossible temperatures, and what might be hiding in the space between
Preface and Index.
The textbook version of the “Out of Africa” hypothesis holds that the first human species to leave the continent around 1.8 million years ago was Homo erectus. But in recent years, a debate has emerged suggesting it wasn’t a single species, but several. New research published in the journal PLOS One now hopes to settle the matter once and for all.
Yang et al. demonstrate that the goblet cell-expressed microprotein FXYD3 interacts with SERCA2 to regulate ER calcium homeostasis, promoting mucus granule secretion and sialylation. FXYD3 deficiency impairs mucin sialylation and mucus barrier function, increasing susceptibility to intestinal inflammation.