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Antibody modulation of B cell responses—Incorporating positive and negative feedback

Antibodies modulate ongoing and future B cell responses. Cyster and Wilson review the various mechanisms whereby antibody feedback shapes B cell responses and present a framework for conceptualizing the ways antigen-specific antibody may influence immunity in conditions as diverse as infectious disease, autoimmunity, and cancer.

Rule-breaking discovery reveals new way to strengthen metal in extreme conditions

There’s a reason why blacksmiths fire metals before hammering them. Heat always softens metal, making it more malleable and easier to reshape. Or does it? In a surprising new study, Northwestern University engineers discovered that, in extreme conditions, heat doesn’t soften pure metals—it strengthens them.

Not only does this new finding challenge long-held assumptions of how metals behave, it also could provide new insights for designing metals for futuristic applications in extreme conditions, such as hypersonic flight, extraterrestrial construction and advanced manufacturing.

The study will be published Tuesday (Feb. 17) in Physical Review Letters.

Turning IBM QRadar Alerts into Action with Criminal IP

Criminal IP now integrates with IBM QRadar SIEM and SOAR to bring external IP-based threat intelligence directly into detection and response workflows. See how risk scoring and automated enrichment help SOC teams prioritize high-risk IPs and accelerate investigations without leaving QRadar.

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