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‘RNA can do things which we have never seen before’: New study challenges assumptions about what RNA was up to at the dawn of life

RNA can fold into more complex configurations than scientists thought, raising questions about how important these 3D structures were when life on Earth began.

Activation mechanism and structural assembly of the Mycobacterium tuberculosis ClpP1P2 protease and its associated ATPases

Weinhäupl et al. determine the cryo-EM structure of the ClpC1P1P2 complex from Mycobacterium tuberculosis, revealing an asymmetric architecture and selective activator binding. They show that molecular crowding promotes assembly and activation of Clp complexes, suggesting a mechanism for ClpP1P2 activation under physiological conditions.