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PI3K/AKT signaling mediates stress-inducible amyloid formation through c-Myc

Lacroix et al. demonstrate that heat-induced activation of the PI3K/AKT signaling cascade drives the formation of functional amyloid aggregates that protect cells from harsh environmental conditions. Here, activation of PI3K and AKT represses GSK3-mediated degradation of c-Myc, leading to upregulation of nucleating noncoding RNAs that mediate this physiological amyloidogenic event.

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