Long-term experimental evolution shows that a single polymerase-encoding RNA replicator can evolve into a complex replicator network, shedding light on how a molecular replicator could have developed complexity before the emergence of life.
Category: evolution – Page 97
Synopsis: No sentient being in the evolutionary history of life has enjoyed good health as defined by the World Health Organization. The founding constitution of the World Health Organization commits the international community to a daringly ambitious conception of health: “a state of complete physical, mental and social wellbeing”. Health as so conceived is inconsistent with evolution via natural selection. Lifelong good health is inconsistent with a Darwinian genome. Indeed, the vision of the World Health Organization evokes the World Transhumanist Association. Transhumanists aspire to a civilization of superhappiness, superlongevity and superintelligence; but even an architecture of mind based on information-sensitive gradients of bliss cannot yield complete well-being. Post-Darwinian life will be sublime, but “complete” well-being is posthuman – more akin to Buddhist nirvana. So the aim of this talk is twofold. First, I shall explore the therapeutic interventions needed to underwrite the WHO conception of good health for everyone – or rather, a recognisable approximation of lifelong good health. What genes, allelic combinations and metabolic pathways must be targeted to deliver a biohappiness revolution: life based entirely on gradients of well-being? How can we devise a more civilized signalling system for human and nonhuman animal life than gradients of mental and physical pain? Secondly, how can genome reformists shift the Overton window of political discourse in favour of hedonic uplift? How can prospective parents worldwide – and the World Health Organization – be encouraged to embrace genome reform? For only germline engineering can fix the problem of suffering and create a happy biosphere for all sentient beings.
The End of Suffering – Genome Reform and the Future of Sentience – David Pearce
Black holes are among the most compelling mysteries of the universe. Nothing, not even light, can escape a black hole. And at the center of nearly every galaxy there is a supermassive black hole that’s millions to billions of times more massive than the sun. Understanding black holes, and how they become supermassive, could shed light on the evolution of the universe.
Three physicists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory have recently developed a model to explain the formation of supermassive black holes, as well as the nature of another phenomenon: dark matter. In a paper published in Physical Review Letters, theoretical physicists Hooman Davoudiasl, Peter Denton, and Julia Gehrlein describe a cosmological phase transition that facilitated the formation of supermassive black holes in a dark sector of the universe.
A cosmological phase transition is akin to a more familiar type of phase transition: bringing water to a boil. When water reaches the exact right temperature, it erupts into bubbles and vapor. Imagine that process taking place with a primordial state of matter. Then, shift the process in reverse so it has a cooling effect and magnify it to the scale of the universe.
Researchers created a mathematical framework to examine the genome and detect signatures of natural selection, deciphering the evolutionary past and future of non-coding DNA.
Despite the sheer number of genes that each human cell contains, these so-called “coding” DNA sequences comprise just 1% of our entire genome. The remaining 99% is made up of “non-coding” DNA — which, unlike coding DNA, does not carry the instructions to build proteins.
One vital function of this non-coding DNA, also called “regulatory” DNA, is to help turn genes on and off, controlling how much (if any) of a protein is made. Over time, as cells replicate their DNA to grow and divide, mutations often crop up in these non-coding regions — sometimes tweaking their function and changing the way they control gene expression. Many of these mutations are trivial, and some are even beneficial. Occasionally, though, they can be associated with increased risk of common diseases, such as type 2 diabetes, or more life-threatening ones, including cancer.
READER QUESTION: If humans don’t die out in a climate apocalypse or asteroid impact in the next 10,000 years, are we likely to evolve further into a more advanced species than what we are at the moment? Harry Bonas, 57, Nigeria
Humanity is the unlikely result of four billion years of evolution.
From self-replicating molecules in Archean seas, to eyeless fish in the Cambrian deep, to mammals scurrying from dinosaurs in the dark, and then, finally, improbably, ourselves—evolution shaped us.
In their pursuit of understanding cosmic evolution, scientists rely on a two-pronged approach. Using advanced instruments, astronomical surveys attempt to look farther and farther into space (and back in time) to study the earliest periods of the Universe. At the same time, scientists create simulations that attempt to model how the Universe has evolved based on our understanding of physics. When the two match, astrophysicists and cosmologists know they are on the right track!
In recent years, increasingly-detailed simulations have been made using increasingly sophisticated supercomputers, which have yielded increasingly accurate results. Recently, an international team of researchers led by the University of Helsinki conducted the most accurate simulations to date. Known as SIBELIUS-DARK, these simulations accurately predicted the evolution of our corner of the cosmos from the Big Bang to the present day.
In addition to the University of Helsinki, the team was comprised of researchers from the Institute for Computational Cosmology (ICC) and the Centre for Extragalactic Astronomy at Durham University, the Lorentz Institute for Theoretical Physics at Leiden University, the Institut d’Astrophysique de Paris, and The Oskar Klein Centre at Stockholm University. The team’s results are published in the Monthly Notices of the Royal Astronomical Society.
Biologists have discovered the largest bacterium ever found, with a single cell measuring a mammoth 2 cm (0.8 in) long. Visible to the naked eye, this new species has some bizarre characteristics that make it like a missing link in the evolution of complex cells like those in humans.
Most species of bacteria measure between one and five micrometers long, but the biggest previously known was Thiomargarita namibiensis, which tops out at 750 micrometers or 0.75 mm. But this newly identified species blows everything else out of the water – its average length is a whopping 9,000 micrometers (0.9 cm/0.4 in), with the largest recorded specimen reaching 2 cm. This single cell is longer than your everyday housefly.
This gigantic size completely upends the accepted scientific understanding of how big bacteria could possibly get. It was long believed that the size of bacteria was limited by the distance that the molecules they exchange with their environment could travel. If nutrients can’t make the journey from their membrane to their interior, and if toxins can’t do the reverse trip, the organism wouldn’t be viable.
Canaanite religion
Posted in evolution
Study of the evolution of monotheism is instructive. Jolly Jehovah did not burst forth fully formed overnight. Prof Orly Goldwasser explains how Amen and Ra are “better” Gods than Set of Avaris, the first recorded monotheist deity in her 2006 paper on King Apophis. There is evidence of interchangeable identity between Set and Ba’al Hadad. “According to the Canaanite pantheon, known in Ugarit as ‘ilhm (=Elohim) or the children of El (cf. the Biblical “sons of God”), supposedly obtained by Philo of Byblos from Sanchuniathon of Berythus (Beirut) the creator was known as Elion (Biblical El Elyon = God most High), who was the father of the divinities, and in the Greek sources he was married to Beruth (Beirut = the city). This marriage of the divinity with the city would seem to have Biblical parallels too with the stories of the link between Melkart and Tyre; Yahweh and Jerusalem; Chemosh and Moab; Tanit and Baal Hammon in Carthage. El Elyon is mentioned as ‘God Most High’ occurs in Genesis 14.18−19 as the God whose priest was Melchizedek king of Salem.”
Canaanite religion is the name for the group of Ancient Semitic religions practiced by the Canaanites living in the ancient Levant from at least the early Bronze Age through the first centuries of the Common Era. Canaanite religion was polytheistic or monolatristic, worshiping one god while acknowledging the existence of others. The sources for Canaanite religion come either from literary sources written by the early Hebrews, or from archaeological discoveries. The Canaanite wrote on papyrus and.
In a way, it could mean climate change is linked to an “immature technosphere”.
It’s called an epiphenomenon.
The idea is that the ordinary function of one thing can generate a secondary effect that seems unrelated and beyond its scope of influence. And when it comes to the interconnected systems of the Earth, we see it all the time.
Plants, for example, found their way via evolution to photosynthesis, which greatly improved their survival. But it also led to them releasing oxygen into the atmosphere, and that changed everything: One form of life seeded a planet-wide transformation, just by pursuing its own nature.
But, if the totality of life (called a biosphere) can radically reshape the Earth, some scientists speculate that cognition — and cognition-related actions — might exhibit the same effect.
This is the “thought experiment” of a group of scientists who blended empirical knowledge of the Earth with more generic ideas about how life changes worlds. And, in the * International Journal of Astrobiology*, they explored the possibility of a “planetary intelligence\.
There is a cyborg organoid platform developed by integrating “tissue-like” stretchable mesh nanoelectronics with 2D stem cell sheets. Leveraging the 2D-to-3D reconfiguration during organoid development, 2D stem cell sheets fold and embed stretchable mesh nanoelectronics with electrodes throughout the entire 3D organoid. The embedded electronics can then enable continuous electrical recording.
Scientists design stretchable mesh nanoelectronics, mimicking the mechanical and structural properties of brain organoids to build cyborg human brain organoids.
Using the 3D embedded stretchable electrodes, achieved reliable long-term electrical recording of the same hiPSC-derived neural tissue at single-cell, millisecond spatiotemporal resolution for 6 months, revealing the evolution of the tissue-wide single-cell electrophysiology over hiPSC-derived neuron development. Applying this technology to brain organoids at early developmental stages, they traced the gradually emerging single-cell action potentials and network activities.
#biomimicry #meshelectronics #hiPSC #neurallace #neuroscience
Building cyborg brain organoids through the integration of stretchable mesh nanoelectronics with human induced pluripotent stem cell derived progenitors and neurons through organogenesis is reported…