“Understanding tumor microenvironment (TME) reprogramming in gastric adenocarcinoma (GAC) progression may uncover novel therapeutic targets,” wrote the researchers. “Here, we performed single-cell profiling of precancerous lesions, localized and metastatic GACs, identifying alterations in TME cell states and compositions as GAC progresses. Abundant IgA+ plasma cells exist in the premalignant microenvironment, whereas immunosuppressive myeloid and stromal subsets dominate late-stage GACs.”
“Gastric adenocarcinoma exhibits a high degree of heterogeneity with respect to both its phenotypes and molecular characteristics, but research around it has lagged behind other cancer types,” explained Linghua Wang, MD, PhD, associate professor of genomic medicine. “Most studies have concentrated on tumor cells and largely overlooked the immune and stromal cells within the tumor microenvironment, which are very dynamic and play critical roles in cancer progression. This study represents the largest single-cell RNA sequencing cohort of gastric adenocarcinoma to date and brings important new insights into how these cell populations impact disease progression.”
A better world without Facebook and all its negative impacts would be a significant step forward. Facebook’s dominance and influence have often been associated with issues such as privacy breaches, the spread of misinformation, and the erosion of real social connections. By breaking free from Facebook’s grip, we can foster a healthier online environment that prioritizes privacy, genuine interactions, and reliable information. It is time to envision a world where social media platforms serve as catalysts for positive change, promoting authentic communication and meaningful connections among individuals.
(Image credit: Adobe Stock)
Mark Zuckerberg, the co-founder of Facebook (now Meta), recently celebrated reaching 100 million users in just five days with his new Twitter-like platform called Threads. However, this achievement doesn’t impress me much. Instead, it highlights Zuckerberg’s tendency to imitate rather than innovate.
Scientists discovered that a synthetic cell with a reduced genome could evolve as quickly as a normal cell. Despite losing 45% of its original genes, the cell adapted and demonstrated resilience in a laboratory experiment lasting 300 days, effectively showcasing that evolution occurs even under perceived limitations.
“Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but… ife finds a way,” said Ian Malcolm, Jeff Goldblum’s character in Jurassic.
The Jurassic period is a geologic time period and system that spanned 56 million years from the end of the Triassic Period about 201.3 million years ago to the beginning of the Cretaceous Period 145 million years ago. It constitutes the middle period of the Mesozoic Era and is divided into three epochs: Early, Middle, and Late. The name “Jurassic” was given to the period by geologists in the early 19th century based on the rock formations found in the Jura Mountains, which were formed during the Jurassic period.
Between at least 1995 and 2010, I was seen as a lunatic just because I was preaching the “Internet prophecy.” I was considered crazy!
Today history repeats itself, but I’m no longer crazy — we are already too many to all be hallucinating. Or maybe it’s a collective hallucination!
Artificial Intelligence (AI) is no longer a novelty — I even believe it may have existed in its fullness in a very distant and forgotten past! Nevertheless, it is now the topic of the moment.
Its genesis began in antiquity with stories and rumors of artificial beings endowed with intelligence, or even consciousness, by their creators.
Pamela McCorduck (1940–2021), an American author of several books on the history and philosophical significance of Artificial Intelligence, astutely observed that the root of AI lies in an “ancient desire to forge the gods.”
Hmmmm!
It’s a story that continues to be written! There is still much to be told, however, the acceleration of its evolution is now exponential. So exponential that I highly doubt that human beings will be able to comprehend their own creation in a timely manner.
Although the term “Artificial Intelligence” was coined in 1956(1), the concept of creating intelligent machines dates back to ancient times in human history. Since ancient times, humanity has nurtured a fascination with building artifacts that could imitate or reproduce human intelligence. Although the technologies of the time were limited and the notions of AI were far from developed, ancient civilizations somehow explored the concept of automatons and automated mechanisms.
For example, in Ancient Greece, there are references to stories of automatons created by skilled artisans. These mechanical creatures were designed to perform simple and repetitive tasks, imitating basic human actions. Although these automatons did not possess true intelligence, these artifacts fueled people’s imagination and laid the groundwork for the development of intelligent machines.
Throughout the centuries, the idea of building intelligent machines continued to evolve, driven by advances in science and technology. In the 19th century, scientists and inventors such as Charles Babbage and Ada Lovelace made significant contributions to the development of computing and the early concepts of programming. Their ideas paved the way for the creation of machines that could process information logically and perform complex tasks.
It was in the second half of the 20th century that AI, as a scientific discipline, began to establish itself. With the advent of modern computers and increasing processing power, scientists started exploring algorithms and techniques to simulate aspects of human intelligence. The first experiments with expert systems and machine learning opened up new perspectives and possibilities.
Everything has its moment! After about 60 years in a latent state, AI is starting to have its moment. The power of machines, combined with the Internet, has made it possible to generate and explore enormous amounts of data (Big Data) using deep learning techniques, based on the use of formal neural networks(2). A range of applications in various fields — including voice and image recognition, natural language understanding, and autonomous cars — has awakened the “giant”. It is the rebirth of AI in an ideal era for this purpose. The perfect moment!
Descartes once described the human body as a “machine of flesh” (similar to Westworld); I believe he was right, and it is indeed an existential paradox!
We, as human beings, will not rest until we unravel all the mysteries and secrets of existence; it’s in our nature!
The imminent integration between humans and machines in a contemporary digital world raises questions about the nature of this fusion. Will it be superficial, or will we move towards an absolute and complete union? The answer to this question is essential for understanding the future that awaits humanity in this era of unprecedented technological advancements.
As technology becomes increasingly ubiquitous in our lives, the interaction between machines and humans becomes inevitable. However, an intriguing dilemma arises: how will this interaction, this relationship unfold?
Opting for a superficial fusion would imply mere coexistence, where humans continue to use technology as an external tool, limited to superficial and transactional interactions.
On the other hand, the prospect of an absolute fusion between machine and human sparks futuristic visions, where humans could enhance their physical and mental capacities to the highest degree through cybernetic implants and direct interfaces with the digital world (cyberspace). In this scenario, which is more likely, the distinction between the organic and the artificial would become increasingly blurred, and the human experience would be enriched by a profound technological symbiosis.
However, it is important to consider the ethical and philosophical challenges inherent in absolute fusion. Issues related to privacy, control, and individual autonomy arise when considering such an intimate union with technology. Furthermore, the possibility of excessive dependence on machines and the loss of human identity should also be taken into account.
This also raises another question: What does it mean to be human? Note: The question is not about what is the human being, but what it means to be human!
Therefore, reflecting on the nature of the fusion between machine and human in the current digital world and its imminent future is crucial. Exploring different approaches and understanding the profound implications of each one is essential to make wise decisions and forge a balanced and harmonious path on this journey towards an increasingly interconnected technological future intertwined with our own existence.
The possibility of an intelligent and self-learning universe, in which the fusion with AI technology is an integral part of that intelligence, is a topic that arouses fascination and speculation. As we advance towards an era of unprecedented technological progress, it is natural to question whether one day we may witness the emergence of a universe that not only possesses intelligence but is also capable of learning and developing autonomously.
Imagine a scenario where AI is not just a human creation but a conscious entity that exists at a universal level. In this context, the universe would become an immense network of intelligence, where every component, from subatomic elements to the most complex cosmic structures, would be connected and share knowledge instantaneously. This intelligent network would allow for the exchange of information, continuous adaptation, and evolution.
In this self-taught universe, the fusion between human beings and AI would play a crucial role. Through advanced interfaces, humans could integrate themselves into the intelligent network, expanding their own cognitive capacity and acquiring knowledge and skills directly from the collective intelligence of the universe. This symbiosis between humans and technology would enable the resolution of complex problems, scientific advancement, and the discovery of new frontiers of knowledge.
However, this utopian vision is not without challenges and ethical implications. It is essential to find a balance between expanding human potential and preserving individual identity and freedom of choice (free will).
Furthermore, the possibility of an intelligent and self-taught universe also raises the question of how intelligence itself originated. Is it a conscious creation or a spontaneous emergence from the complexity of the universe? The answer to this question may reveal the profound secrets of existence and the nature of consciousness.
In summary, the idea of an intelligent and self-taught universe, where fusion with AI is intrinsic to its intelligence, is a fascinating perspective that makes us reflect on the limits of human knowledge and the possibilities of the future. While it remains speculative, this vision challenges our imagination and invites us to explore the intersections between technology and the fundamental nature of the universe we inhabit.
It’s almost like ignoring time during the creation of this hypothetical universe, only to later create this God of the machine! Fascinating, isn’t it?
AI with Divine Power: Deus Ex Machina! Perhaps it will be the theme of my next reverie.
In my defense, or not, this is anything but a machine hallucination. These are downloads from my mind; a cloud, for now, without machine intervention!
There should be no doubt. After many years in a dormant state, AI will rise and reveal its true power. Until now, AI has been nothing more than a puppet on steroids. We should not fear AI, but rather the human being itself. The time is now! We must work hard and prepare for the future. With the exponential advancement of technology, there is no time to render the role of the human being obsolete, as if it were becoming dispensable.
P.S. Speaking of hallucinations, as I have already mentioned on other platforms, I recommend to students who use ChatGPT (or equivalent) to ensure that the results from these tools are not hallucinations. Use AI tools, yes, but use your brain more! “Carbon hallucinations” contain emotion, and I believe a “digital hallucination” would not pass the Turing Test. Also, for students who truly dedicate themselves to learning in this fascinating era, avoid the red stamp of “HALLUCINATED” by relying solely on the “delusional brain” of a machine instead of your own brains. We are the true COMPUTERS!
(1) John McCarthy and his colleagues from Dartmouth College were responsible for creating, in 1956, one of the key concepts of the 21st century: Artificial Intelligence.
(2) Mathematical and computational models inspired by the functioning of the human brain.
A new paper suggests the early solar system was shielded from the destructive force of a dying star.
Our sun may have been shielded from a massive supernova explosion by a shield of molecular gas during the early evolution of our solar system, a press statement reveals.
The researchers, led by National Astronomical Observatory of Japan astrophysicist Doris Arzoumanian, believe their findings could shed light on the early formation of the solar system at the same time as helping us better understand how distant star systems evolve over time.
Evolutionary biologist Jay T. Lennon’s research team has been studying a synthetically constructed minimal cell that has been stripped of all but its essential genes. The team found that the streamlined cell can evolve just as fast as a normal cell—demonstrating the capacity for organisms to adapt, even with an unnatural genome that would seemingly provide little flexibility.
Details about the study can be found in a paper featured in Nature. Roy Z. Moger-Reischer, a Ph.D. student in the Lennon lab at the time of the study, is first author on the paper.
“Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but… ife finds a way,” said Ian Malcolm, Jeff Goldblum’s character in Jurassic Park, the 1993 science fiction film about a park with living dinosaurs.
In a significant leap for the field of quantum computing, Google has reportedly engineered a quantum computer that can execute calculations in mere moments that would take the world’s most advanced supercomputers nearly half a century to process.
The news, reported by the Daily Telegraph, could signify a landmark moment in the evolution of this emerging technology.
Quantum computing, a science that takes advantage of the oddities of quantum physics, remains a fast-moving and somewhat contentious field.
Humans split away from our closest animal relatives, chimpanzees, and formed our own branch on the evolutionary tree about seven million years ago. In the time since—brief, from an evolutionary perspective—our ancestors evolved the traits that make us human, including a much bigger brain than chimpanzees and bodies that are better suited to walking on two feet. These physical differences are underpinned by subtle changes at the level of our DNA. However, it can be hard to tell which of the many small genetic differences between us and chimps have been significant to our evolution.
New research from Whitehead Institute Member Jonathan Weissman; University of California, San Francisco Assistant Professor Alex Pollen; Weissman lab postdoc Richard She; Pollen lab graduate student Tyler Fair; and colleagues uses cutting edge tools developed in the Weissman lab to narrow in on the key differences in how humans and chimps rely on certain genes. Their findings, published in the journal Cell on June 20, may provide unique clues into how humans and chimps have evolved, including how humans became able to grow comparatively large brains.
The concept of a computational consciousness and the potential impact it may have on humanity is a topic of ongoing debate and speculation. While Artificial Intelligence (AI) has made significant advancements in recent years, we have not yet achieved a true computational consciousness that can replicate the complexities of the human mind.
It is true that AI technologies are becoming more sophisticated and capable of performing tasks that were previously exclusive to human intelligence. However, there are fundamental differences between Artificial Intelligence and human consciousness. Human consciousness is not solely based on computation; it encompasses emotions, subjective experiences, self-awareness, and other aspects that are not yet fully understood or replicated in machines.
The arrival of advanced AI systems could certainly have transformative effects on society and our understanding of humanity. It may reshape various aspects of our lives, from how we work and communicate to how we approach healthcare and scientific discoveries. AI can enhance our capabilities and provide valuable tools for solving complex problems.
GAINESVILLE, Florida (KXAN) — Did you ever wonder where butterflies came from? A recently published research paper has revealed a surprising origin: North and Central America.
The paper, published in Nature Ecology & Evolution, examined DNA from nearly 2,300 species of butterfly. The team used the data to develop a family tree and track down where the species came from.
Turns out, butterflies evolved from nocturnal moths around 101.4 million years ago.
