Tiny implantable sensors are helping University of Oregon researchers optimize the process of recovery from severe bone injuries.

Scientists at the UO’s Phil and Penny Knight Campus for Accelerating Scientific Impact have developed miniature implantable sensors that transmit real-time data about what’s happening at an injury site. In a new study, they use the technology to show that a resistance-training rehabilitation program can significantly improve femur injuries in rats in just eight weeks.

The sensors provide a window into the mechanical properties of the bone, giving scientists detailed ongoing data about the process of healing. If someday applied in humans, these sensors could allow doctors to better tailor a rehabilitation program to an individual patient, monitoring their progress and adjusting the exercises along the way.

Magnetic resonance imaging (MRI) is a fundamental tool in modern medicine, offering detailed views of internal organs and tissues. These large, tube-shaped MRI machines, commonly seen in hospitals, utilize powerful magnets to analyze and visualize the density of water and fat molecules within the body.

In addition to these molecules, other substances like metabolites can also be mapped, but their concentrations are often too low to produce clear images. To overcome this limitation, a technique known as hyperpolarization is employed to enhance the magnetic resonance signal of these substances, making them more visible during MRI scans.

Hyperpolarization involves preparing a substance outside the body in a state where its magnetization—key to creating MRI images—is near its maximum. This process can boost the signal by thousands of times compared to its natural state. Once hyperpolarized, the substance is injected into the patient and transported to the target organ or tissue. However, before this can happen, it is crucial to confirm that the substance is adequately hyperpolarized through rigorous quality control processes.