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Category: chemistry – Page 67

Oxygen discovered in most distant known galaxy

Two different teams of astronomers have detected oxygen in the most distant known galaxy, JADES-GS-z14-0. The discovery, reported in two separate studies, was made possible thanks to the Atacama Large Millimeter/submillimeter Array (ALMA), in which the European Southern Observatory (ESO) is a partner. This record-breaking detection is making astronomers rethink how quickly galaxies formed in the early universe.

Discovered last year, JADES-GS-z14-0 is the most distant confirmed galaxy ever found: it is so far away, its light took 13.4 billion years to reach us, meaning we see it as it was when the universe was less than 300 million years old, about 2% of its present age.

The new oxygen detection with ALMA, a telescope array in Chile’s Atacama Desert, suggests the galaxy is much more chemically mature than expected.

FAST detects new ultra-faint dwarf galaxy

Using the Five-hundred-meter Aperture Spherical radio Telescope (FAST), Chinese astronomers have detected a new ultra-faint dwarf galaxy, which turned out to be gas-rich. The finding was reported in a research paper published March 12 on the preprint server arXiv.

The so-called ultra-faint dwarf (UFDs) are the least luminous, most –dominated, and least chemically evolved galaxies known. Therefore, they are perceived by astronomers as the best candidate fossils from the universe at its early stages.

A team of astronomers led by Jin-Long Xu of the Chinese Academy of Sciences (CAS) is carrying out a FAST extragalactic H I (neutral atomic hydrogen) survey (FASHI). One of the objectives of this survey is to search for dark and weak galaxies. Now, they report the finding of a new UFD as part of this project.

Light chemistry could lead to better medicines

“We have found a key to controlling the switching on and off of proteins by combining photochemistry and hydrolysis,” says KTH researcher Tove Kivijärvi.

When designing materials that aim to improve medicine, you need to be able to control the functions of the material in a very precise way. If this is achieved, cell environments similar to the human body can be created in the lab, which is important for understanding biological mechanisms, disease processes and how the body repairs itself. Biological materials can also be used to study how drugs work and to streamline drug testing and preclinical studies.

Fighting coastal erosion with electricity

New research from Northwestern University has systematically proven that a mild zap of electricity can strengthen a marine coastline for generations—greatly reducing the threat of erosion in the face of climate change and rising sea levels.

In the new study, researchers took inspiration from clams, mussels and other shell-dwelling sea life, which use dissolved minerals in seawater to build their shells.

Similarly, the researchers leveraged the same naturally occurring, dissolved minerals to form a natural cement between sea-soaked grains of sand. But, instead of using metabolic energy like mollusks do, the researchers used to spur the chemical reaction.

Scientists gain insight into RNA-editing protein that could lead to improved treatment for cancer, autoimmune diseases

A research team led by Rice University’s Yang Gao has uncovered new insights into the molecular mechanisms of ADAR1, a protein that regulates ribonucleic acid (RNA) induced immune responses. Their findings, published in Molecular Cell March 17, could open new pathways for treating autoimmune diseases and enhancing cancer immunotherapy.

ADAR1 converts adenosine to inosine in double-stranded RNA, a process essential for preventing unwarranted immune responses, yet the molecular basis of this editing had remained unclear. Through detailed biochemical profiling and structural analysis, researchers found that ADAR1’s editing activity depends on RNA sequence, duplex length and mismatches near the editing site. High-resolution structures of ADAR1 bound to RNA reveal its mechanisms for RNA binding, substrate selection and dimerization.

“Our study provides a comprehensive understanding of how ADAR1 recognizes and processes RNA,” said Gao, assistant professor of biosciences and a Cancer Prevention and Research Institute of Texas (CPRIT) Scholar. “These insights pave the way for novel therapeutic strategies targeting ADAR1-related diseases.”

Never-Before-Seen: UCLA Physicists Discover Mysterious Spiral Patterns on Solid Surfaces

A curiosity about tiny dots on a germanium wafer with metal films led to the discovery of intricate spiral patterns etched by a chemical reaction. Further experiments revealed that these patterns emerge from chemical reactions interacting with mechanical forces through a deforming catalyst. This breakthrough marks the most significant advance in studying chemical pattern formation since the 1950s. Understanding these complex systems could shed light on natural processes like crack formation in materials and the effects of stress on biological growth.

University of California, Los Angeles doctoral student Yilin Wong noticed tiny dots appearing on one of her samples, which had been accidentally left out overnight. The layered sample consisted of a germanium wafer topped with evaporated metal films in contact with a drop of water. On a whim, she examined the dots under a microscope and couldn’t believe her eyes. Beautiful spiral patterns had been etched into the germanium surface by a chemical reaction.

Wong’s curiosity led her on a journey of discovery, revealing something never seen before: hundreds of nearly identical spiral patterns spontaneously forming on a centimeter-square germanium chip. Even more remarkably, small changes in experimental parameters, such as the thickness of the metal film, produced different patterns, including Archimedean spirals, logarithmic spirals, lotus flower shapes, radially symmetric patterns, and more.

New Heavy Metal Molecule Could Reveal What Goes on Inside Nuclear Waste

Since it was first synthesized in a post-WW2 American lab in 1949, berkelium has been a rebel of the periodic table, defying quantum mechanics and taking on an extra positive charge that its relatives would never.

Now, a team of scientists from berkelium’s alma mater, Lawrence Berkeley National Laboratory, has wrangled the elusive element into a rare partnership with carbon that will enable them to study it in more detail.

Thanks to challenges involved in producing and safely containing the heavy element, few chemists have had the privilege of dealing with berkelium. Just one gram of the stuff can cost a boggling US$27 million. For this experiment, just 0.3 milligrams of berkelium-249 was required.

Electrons travel one of two routes in nano-biohybrid systems

Peanut butter and jelly. Simon and Garfunkel. Semiconductors and bacteria. Some combinations are more durable than others. In recent years, an interdisciplinary team of Cornell researchers has been pairing microbes with the semiconductor nanocrystals known as quantum dots, with the goal of creating nano-biohybrid systems that can harvest sunlight to perform complex chemical transformations for materials and energy applications.

Now, the team has for the first time identified exactly what happens when a microbe receives an electron from a quantum dot: The charge can either follow a direct pathway or be transferred indirectly via the microbe’s shuttle molecules.

The findings are published in Proceedings of the National Academy of Sciences. The lead author is Mokshin Suri.

Epidermal Growth Factor Stability and Cell Proliferation Enhanced by Antioxidants

1. Introduction.

The natural production of EGF, a short polypeptide hormone, promotes the processes of proliferation, expansion, and division of cells [1]. For in vitro cell culture, EGF functions as a growth factor [2] and has an effective mitogenic effect on endothelial cells, fibroblasts, and most epithelial tissues. Its biological functions rely on associating itself with a specific cell membrane receptor [3]. Because EGF plays a crucial role as a mitogen in the proliferation of various cell types both in vivo and in vitro, it has been used in the therapeutic and cosmetic areas [4] to cover scars and reduce the appearance of aging skin [1]. Moreover, recombinant EGF is used topically for diabetic foot ulcers [5]. The structures and properties of proteins vary; favorable conditions are necessary for conformation, stability, and proper function. In contrast, a protein degrades, denatures, or precipitates when it is exposed to unfavorable conditions or when its natural environment changes suddenly. Recombinant human EGF is most frequently degraded by oxidation and deamidation [6]. These reactions typically have long-term implications. For protein solutions to remain stable and have a longer shelf life, excipients may need to be added, depending on how the protein is used in the experiment and other factors. When it comes to the chemical and physical degradation of proteins, the solution environment plays a crucial role in protein formulations. Of particular concern are buffer types, pH, and antioxidants [7]. Even though antioxidants assist in stability and solubility in liquid solutions, which help to preserve protein structure and function, they are frequently considered inactive ingredients in pharmaceutical compositions [8] [9].

Since an unstable protein solution can impact the product’s appearance, potency, purity, healing effects, and cell proliferation, in vitro protein stabilization is an essential practical consideration for the development of an effective EGF formulation. The stability of EGF in solution has been well documented in several in vivo solutions [10]. Though there have been numerous reports on EGF stability, none have specifically addressed treatment in cell culture conditions. Since it has a big influence on several aspects of the parenteral formulation creation process and EGF-based cell proliferation, the study of EGF stability in cell culture medium has gotten little attention. But since many of these in vitro tests are conducted in non-physiological settings, such as organic solvents or acidic solutions [11], they frequently fail to yield qualitatively positive results in cellular therapies.

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