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Nanopore direct RNA sequencing finds cancer’s ‘fingerprint’ to improve early detection

Different types of cancer have unique molecular “fingerprints” which are detectable in early stages of the disease and can be picked up with near-perfect accuracy by small, portable scanners in just a few hours, according to a study published today in the journal Molecular Cell.

The discovery by researchers at the Centre for Genomic Regulation (CRG) in Barcelona sets the foundation for creating new, non-invasive diagnostic tests that detect different types of cancer faster and earlier than currently possible.

The study centers around the ribosome, the protein factories of a cell. For decades, ribosomes were thought to have the same blueprint across the human body. However, researchers discovered a hidden layer of complexity—tiny chemical modifications which vary between different tissues, developmental stages, and disease.