Lifeboat Foundation

Innovating At The Frontiers Of Cancer Biology — Dr. Jonathan Chernoff MD, PhD, Senior Vice President, Deputy Director, and Chief Scientific Officer, Fox Chase Cancer Center.

Dr. Jonathan Chernoff, MD, PhD, is Senior Vice President, Deputy Director, and Chief Scientific Officer, at Fox Chase Cancer Center (https://www.foxchase.org/) where he coordinates and charts the future course of research for the organization.

Continue reading “Dr. Jonathan Chernoff, MD, PhD — Senior VP, Deputy Director, and CSO — Fox Chase Cancer Center” »

Various insect species serve as valuable model systems for investigating the cellular and molecular mechanisms by which a brain controls sophisticated behaviors. In particular, the nervous system of Drosophila melanogaster has been extensively studied, yet experiments aimed at determining the number of neurons in the Drosophila brain are surprisingly lacking. Using isotropic fractionator coupled with immunohistochemistry, we counted the total number of neuronal and non-neuronal cells in the whole brain, central brain, and optic lobe of Drosophila melanogaster. For comparison, we also counted neuronal populations in three divergent mosquito species: Aedes aegypti, Anopheles coluzzii and Culex quinquefasciatus. The average number of neurons in a whole adult brain was determined to be 199380 ±3400 cells in D. melanogaster, 217910 ±6180 cells in Ae. aegypti, 223020 ± 4650 cells in An. coluzzii and 225911±7220 cells in C. quinquefasciatus. The mean neuronal cell count in the central brain vs. optic lobes for D. melanogaster (101140 ±3650 vs. 107270 ± 2720), Ae. aegypti (109140 ± 3550 vs. 112000 ± 4280), An. coluzzii (105130 ± 3670 vs. 107140 ± 3090), and C. quinquefasciatus (108530 ±7990 vs. 110670 ± 3950) was also estimated. Each insect brain was comprised of 89% ± 2% neurons out of its total cell population. Isotropic fractionation analyses did not identify obvious sexual dimorphism in the neuronal and non-neuronal cell population of these insects. Our study provides experimental evidence for the total number of neurons in Drosophila and mosquito brains.

Citation: Raji JI, Potter CJ (2021) The number of neurons in Drosophila and mosquito brains. PLoS ONE 16: e0250381. https://doi.org/10.1371/journal.pone.

Editor: Matthieu Louis, University of California Santa Barbara, UNITED STATES.

The biological clock is present in almost all cells of an organism. As more and more evidence emerges that clocks in certain organs could be out of sync, there is a need to investigate and reset these clocks locally. Scientists from the Netherlands and Japan introduced a light-controlled on/off switch to a kinase inhibitor, which affects clock function. This gives them control of the biological clock in cultured cells and explanted tissue. They published their results on 26 May in Nature Communications.

Life on Earth has evolved under a 24-hour cycle of light and dark, hot and cold. “As a result, our cells are synchronized to these 24-hour oscillations,” says Wiktor Szymanski, Professor of Radiological Chemistry at the University Medical Center Groningen. Our circadian clock is regulated by a central controller in the suprachiasmatic nucleus, a region in the brain directly above the optic nerve, but all our cells contain a clock of their own. These clocks consist of an oscillation in the production and breakdown of certain proteins.

The wonderful mess of molecules that make up living things is so complex, biologists have overlooked an entire class of them – until now. This missed bit of biochemistry is neither rare nor hard to find; it’s just no one had thought to look for it before.

“This is a stunning discovery of an entirely new class of biomolecules,” said Stanford biochemist Carolyn Bertozzi.

“It’s really a bombshell because the discovery suggests that there are biomolecular pathways in the cell that are completely unknown to us.”

Circa 2016 o.o!

The theory used to be that hydrocarbons were created in “shocks,” or violent stellar events that cause a lot of turbulence and, with the shock waves, make atoms into ions, which are more likely to combine.

The data from the European Space Agency’s Herschel Space Observatory has since proved that theory wrong. Scientists at Herschel studied the components in the Orion Nebula, mapping the amount, temperature and motions for the carbon-hydrogen molecule (CH), the carbon-hydrogen positive ion (CH+) and their parent molecule: the carbon ion (C+).

Continue reading “Scientists find ultraviolet light may create life-essential chemicals” »

Paradoxically, Jupiter’s ice-covered moon of Europa may have seafloor volcanoes capable of generating enough chemical energy and heat to support life, says new paper.

Researchers have also long been chasing lithium-air batteries that could realize a huge jump in energy density. And beyond lithium, there are other entirely different chemistries in development out there. At some point, one of them should click for one application or another.

Lithium-ion or not, an explosion of grid-scale battery installations is coming as prices continue to fall. The nascent art of lithium-ion battery recycling is also sure to mature and expand, improving the sustainability of these batteries by recovering and resetting their chemical building blocks.

Adopt cold-fusion-like skepticism of any of these future-looking statements as you please, but today’s batteries aren’t those of 20 or even 10 years ago. The same thing is bound to be true in another 10 years—even if that progress doesn’t come in a single, giant leap with global fanfare.

A new topic a new challenge for future civilizations.

I won’t write an introduction I will ask couple of questions to make you think about it.

Continue reading “Spermageddon: are humans going extinct?” »

How do simple creatures manage to move to a specific place? Artificial intelligence and a physical model from TU Wien can now explain this.

How is it possible to move in the desired direction without a brain or nervous system? Single-celled organisms apparently manage this feat without any problems: for example, they can swim towards food with the help of small flagellar tails.

How these extremely simply built creatures manage to do this was not entirely clear until now. However, a research team at TU Wien (Vienna) has now been able to simulate this process on the computer: They calculated the physical interaction between a very simple model organism and its environment. This environment is a liquid with a non-uniform chemical composition, it contains food sources that are unevenly distributed.