Lifeboat Foundation

Thanks to new RNA vaccines, we humans have been able to protect ourselves incredibly quickly from new viruses like SARS-CoV-2, the virus that causes COVID-19. These vaccines insert a piece of ephemeral genetic material into the body’s cells, which then read its code and churn out a specific protein—in this case, telltale “spikes” that stud the outside of the coronavirus—priming the immune system to fight future invaders.

The technique is effective, and has promise for all sorts of therapies, says Eerik Kaseniit, Ph.D. student in bioengineering at Stanford. At the moment, though, these sorts of RNA therapies can’t focus on specific cells. Once injected into the body, they indiscriminately make the encoded protein in every cell they enter. If you want to use them to treat only one kind of cell—like those inside a cancerous tumor—you’ll need something more precise.

Kaseniit and his advisor, assistant professor of chemical engineering Xiaojing Gao, may have found a way to make this possible. They’ve created a new tool called an RNA “sensor”—a strand of lab-made RNA that reveals its contents only when it enters particular tissues within the body. The method is so exact that it can home in on both cell types and cell states, activating only when its target cell is creating a certain RNA, says Gao. The pair published their findings Oct. 5 in the journal Nature Biotechnology.

Although just cute little creatures at first glance, the microscopic geckos and octopuses fabricated by 3D laser printing in the molecular engineering labs at Heidelberg University could open up new opportunities in fields such as microrobotics or biomedicine.

The printed microstructures are made from novel materials —known as smart polymers—whose size and mechanical properties can be tuned on demand and with high precision. These “life-like” 3D microstructures were developed in the framework of the “3D Matter Made to Order” (3DMM2O) Cluster of Excellence, a collaboration between Ruperto Carola and the Karlsruhe Institute of Technology (KIT).

“Manufacturing programmable materials whose mechanical properties can be adapted on demand is highly desired for many applications,” states Junior Professor Dr. Eva Blasco, group leader at the Institute of Organic Chemistry and the Institute for Molecular Systems Engineering and Advanced Materials of Heidelberg University.

The researchers brilliantly demonstrated, for the very first time, how to chemically transform an abundant, plant-based starting material into EBC-46.

In what can be called a major scientific breakthrough, Stanford researchers have discovered a “rapid and sustainable” way to synthetically produce a promising cancer-fighting compound, designated EBC-46, right in the lab, according to a press release published by the institution.

This was “something many people had considered impossible,” as the compound’s only currently known source is a single plant species that grows solely in a small rainforest region of Northeastern Australia.

Tsakli (and related Buddhist artworks) Exhibition now started. I will add new updates over the coming weeks.

Tsakli (Tsakali) Tibetan, Mongolian & Himalayan Buddhist artwork. Paintings, drawings, antique prints, manuscripts, divination and alchemical items, tantra.

An electrolyte moves ions – atoms that have been charged by either gaining or losing an electron – between the two electrodes in a battery. Lithium ions are created at the negative electrode, the anode, and flow to the cathode where they gain electrons. When a battery charges, the ions move back to the anode.

Battery innovations can take years to come to fruition because there are so many different chemicals involved in their production. Working out the ratio of chemicals and optimising them for peak use can be an arduous task.

However, when the research team used an automated arrangement of pumps, valves, vessels, and other lab equipment to mix together three potential solvents and one salt, and then fed those results through ‘Dragonfly’, they found that the AI delivered six solutions that out-performed an existing electrolyte solution.

When it comes to developing treatments and eventual cures for diseases, being able to diagnose a condition early and accurately makes a huge difference – and scientists have now developed a quick, reliable method of identifying people with Parkinson’s disease.

The test can be run in as little as 3 minutes after a skin swab has been taken. The swab is analyzed for changes in the chemical mix of sebum, a natural waxy oil produced by the skin that has previously been linked to Parkinson’s.

At the moment, there’s no conclusive test for Parkinson’s disease – specialists look at symptoms, medical history, the results of a lengthy physical examination, and in some cases, a brain scan to diagnose the condition.

A new origins-based system for classifying minerals reveals the huge geochemical imprint that life has left on Earth. It could help us identify other worlds with life too.

The last decade has brought a lot of attention to the use of microscopic robots (microrobots or nanorobots) for biomedical applications. Now, nanoengineers have developed microrobots that can swim around in the lungs and deliver medication to be used to treat bacterial pneumonia. A new study shows that the microrobots safely eliminated pneumonia-causing bacteria in the lungs of mice and resulted in 100% survival. By contrast, untreated mice all died within three days after infection.

The results are published Nature Materials in the paper, “Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia.”

The microrobots are made using click chemistry to attach antibiotic-loaded neutrophil membrane-coated polymeric nanoparticles to natural microalgae. The hybrid microrobots could be used for the active delivery of antibiotics in the lungs in vivo.

Scientists managed to start the same chemical process that powers the Sun on August 8, 2021, by putting more electricity into a tiny gold capsule than the entire US electric system could handle.

It is extremely astonishing how the power of 192 laser beams sparked the same thermonuclear fire that fuels the Sun for a nanosecond.

The Sun produces energy by hurling hydrogen atoms together, generating helium in the process. We are now closer than ever to being able to harness chemical reactions with enough force to power the Sun. This is possible because fusion power technology has advanced.