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Imagine a skin cream that heals damage occurring throughout the day when your skin is exposed to sunlight or environmental toxins. That’s the potential of a synthetic, biomimetic melanin developed by scientists at Northwestern University.
In a new study, the scientists show that their synthetic melanin, mimicking the natural melanin in human skin, can be applied topically to injured skin, where it accelerates wound healing. These effects occur both in the skin itself and systemically in the body.
When applied in a cream, the synthetic melanin can protect skin from sun exposure and heals skin injured by sun damage or chemical burns, the scientists said. The technology works by scavenging free radicals, which are produced by injured skin such as a sunburn. Left unchecked, free radical activity damages cells and ultimately may result in skin aging and skin cancer.
Oak Ridge National Laboratory’s research in quantum biology and AI has significantly improved the efficiency of CRISPR Cas9 genome editing in microbes, aiding in renewable energy development.
Scientists at Oak Ridge National Laboratory (ORNL) used their expertise in quantum biology, artificial intelligence, and bioengineering to improve how CRISPR Cas9 genome editing tools work on organisms like microbes that can be modified to produce renewable fuels and chemicals.
CRISPR is a powerful tool for bioengineering, used to modify genetic code to improve an organism’s performance or to correct mutations. The CRISPR Cas9 tool relies on a single, unique guide RNA.
“Plastic recycling has been touted as a solution to the plastics pollution crisis, but toxic chemicals in plastics complicate their reuse and disposal and hinder recycling.”
As such, plastic recycling today is an essential part of waste management and environmental preservation initiatives. Recycling plastics minimizes the environmental impact of plastic manufacturing, conserves energy, and helps lower the need for new raw materials.
A crucial sustainable process
However, a new study is putting a damper on this crucial sustainable process. Researchers from the University of Gothenburg investigated recycled plastic pellets gathered from 13 different nations and discovered they contained hundreds of hazardous substances, including pharmaceuticals and pesticides.
Researchers at the University of São Paulo (USP) in Brazil, partnering with colleagues in Australia, have identified a novel bacterial protein that can keep human cells healthy even when the cells have a heavy bacterial burden. The discovery could lead to new treatments for a wide array of diseases relating to mitochondrial dysfunction, such as cancer and auto-immune disorders. Mitochondria are organelles that supply most of the chemical energy needed to power cells’ biochemical reactions.
The study is published in the journal PNAS. The researchers analyzed more than 130 proteins released by Coxiella burnetii when this bacterium invades host cells, and found at least one to be capable of prolonging cell longevity by acting directly on mitochondria.
After invading host cells, C. burnetii releases a hitherto unknown protein, which the authors call mitochondrial coxiella effector F (MceF). MceF interacts with glutathione peroxidase 4 (GPX4), an anti-oxidant enzyme located in the mitochondria, to improve mitochondrial function by promoting an anti-oxidizing effect that averts cell damage and death, which may occur when pathogens replicate inside mammalian cells.
Lasers are essential tools for observing, detecting, and measuring things in the natural world that we can’t see with the naked eye. But the ability to perform these tasks is often restricted by the need to use expensive and large instruments.
In a newly published cover-story paper in the journal Science, researcher Qiushi Guo demonstrates a novel approach for creating high-performance ultrafast lasers on nanophotonic chips. His work centers on miniaturizing mode-lock lasers—a unique laser that emits a train of ultrashort, coherent light pulses in femtosecond intervals, which is an astonishing quadrillionth of a second.
Ultrafast mode-locked lasers are indispensable to unlocking the secrets of the fastest timescales in nature, such as the making or breaking of molecular bonds during chemical reactions, or light propagation in a turbulent medium. The high-speed, pulse-peak intensity and broad-spectrum coverage of mode-locked lasers have also enabled numerous photonics technologies, including optical atomic clocks, biological imaging, and computers that use light to calculate and process data.
The system shows potential for drug development in delicate environments such as coral reefs.
ACS
To better comprehend this, researchers have presented a proof-of-concept device that “sniffs” seawater, capturing dissolved chemicals for analysis. The underwater device “catches and concentrates dissolved substances generated by sponges or other marine animals while causing no damage to the source or the environment,” said a statement.
One person is injured after glue factory explosion, which sparked school evacuations and road closures.
A combined team of biomedical researchers from Novartis Institutes for Biomedical Research and Microsoft Research AI4Science has made inroads into teaching AI systems how to find new medicines. In their study, reported in the journal Nature Communications, the group used feedback from chemists in the field to provide intuition guidelines for an AI model.
Finding new medicines is a notoriously difficult and laborious task. The process for finding new therapies typically involves experts in a variety of fields working on different parts of the problem. Doctors and other medical researchers, for example, must first uncover the roots of a given illness to find its cause. Chemists or other medical researchers must then find a chemical that might reverse the problem or stop it from happening in the first place.
Both parts of the process take time and effort. In this new project, the research team sought to determine whether AI applications might make the second part easier.
Scientists at Oak Ridge National Laboratory have used their expertise in quantum biology, artificial intelligence and bioengineering to improve how CRISPR Cas9 genome editing tools work on organisms like microbes that can be modified to produce renewable fuels and chemicals.
CRISPR is a powerful tool for bioengineering, used to modify genetic code to improve an organism’s performance or to correct mutations. The CRISPR Cas9 tool relies on a single, unique guide RNA that directs the Cas9 enzyme to bind with and cleave the corresponding targeted site in the genome.
Existing models to computationally predict effective guide RNAs for CRISPR tools were built on data from only a few model species, with weak, inconsistent efficiency when applied to microbes.
