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Companies could one day make superconductive quantum computer chips that function at room temperature thanks to a new material from researchers in the US. Ranga Dias from the University of Rochester and colleagues made a material superconductive at 21°C and pressures less than 1% of those used for existing high-temperature superconductors. ‘The most exciting part is the pressure,’ Dias tells Chemistry World. ‘Even I didn’t think this was possible.’

Together with Ashkan Salamat’s team at the University of Nevada, Las Vegas, the scientists say that electrical resistance in their nitrogen-doped lutetium hydride falls to zero at room temperature. Making room-temperature zero-resistance materials is a chemistry ‘holy grail’ and could fight climate change by reducing the 5% of electricity lost as heat while flowing through the grid.

However, Dias and Salamat’s team hasn’t been able to fully confirm the new material’s structure. As hydrogen atoms are so small they don’t easily diffract the x-rays used to work out the material’s composition. And this is an important reservation, considering the publisher of the team’s previous high-temperature superconductor paper retracted it.

Structural and biochemical studies of the Mycobacterium smegmatis hydrogenase Huc provides insights into how [NiFe] hydrogenases oxidize trace amounts of atmospheric hydrogen and transfer the electrons liberated via quinone transport.

Studying the relationship between the arrangement of water molecules incorporated into layered materials like clays and the arrangement of ions within these materials has been a difficult experiment to conduct.

However, researchers have now succeeded in observing these interactions for the first time by utilizing a technique commonly used for measuring extremely small masses and molecular interactions at the nanoscale.

The nanoscale refers to a length scale that is extremely small, typically on the order of nanometers (nm), which is one billionth of a meter. At this scale, materials and systems exhibit unique properties and behaviors that are different from those observed at larger length scales. The prefix “nano-” is derived from the Greek word “nanos,” which means “dwarf” or “very small.” Nanoscale phenomena are relevant to many fields, including materials science, chemistry, biology, and physics.

Recent advances in human stem cell-derived brain organoids promise to replicate critical molecular and cellular aspects of learning and memory and possibly aspects of cognition in vitro. Coining the term “organoid intelligence” (OI) to encompass these developments, we present a collaborative program to implement the vision of a multidisciplinary field of OI. This aims to establish OI as a form of genuine biological computing that harnesses brain organoids using scientific and bioengineering advances in an ethically responsible manner. Standardized, 3D, myelinated brain organoids can now be produced with high cell density and enriched levels of glial cells and gene expression critical for learning. Integrated microfluidic perfusion systems can support scalable and durable culturing, and spatiotemporal chemical signaling.

Summary: Utilizing a classic neural network, researchers have created a new artificial intelligence model based on recent biological findings that shows improved memory performance.

Source: OIST

Computer models are an important tool for studying how the brain makes and stores memories and other types of complex information. But creating such models is a tricky business. Somehow, a symphony of signals – both biochemical and electrical – and a tangle of connections between neurons and other cell types creates the hardware for memories to take hold. Yet because neuroscientists don’t fully understand the underlying biology of the brain, encoding the process into a computer model in order to study it further has been a challenge.

Aromatic bonds, particularly strong chemical bonds which form in some ring-shaped molecules, are a crucial building block of the world around us. They appear in everything from proteins to aspirin, and literally millions of natural and synthetic substances in between.

The bonds are very hard to break and to control, and their properties have puzzled chemists for more than a century.

Which is just the motivation chemists needed to break and control them, and now a group of UK researchers has figured out how to twist an aromatic bond until it breaks.

The development represents “an important advance in extraterrestrial research, in which biology has often lagged behind chemistry and geology.”

A new study has revealed a new way to enhance the search for aliens on Mars by teaching artificial intelligence to detect sites that could contain “biosignatures.”

And so, the researchers trained a deep learning framework to map biosignatures in a three-square-kilometer area of Chile’s Atacama Desert… More.

Continue reading “New AI tool can aid scientists in hunting for life on Mars” »

A team of biologists has discovered how to awaken neural stem cells and reactivate them in adult mice.

Some areas of the adult brain contain quiescent, or dormant, neural stem cells that can potentially be reactivated to form new neurons. However, the transition from quiescence to proliferation is still poorly understood. A team led by scientists from the Universities of Geneva (UNIGE) and Lausanne (UNIL) has discovered the importance of cell metabolism in this process and identified how to wake up these neural stem cells and reactivate them. Biologists succeeded in increasing the number of new neurons in the brain of adult and even elderly mice. These results, promising for the treatment of neurodegenerative diseases, are to be discovered in the journal Science Advances.

<em>Science Advances</em> is a peer-reviewed, open-access scientific journal that is published by the American Association for the Advancement of Science (AAAS). It was launched in 2015 and covers a wide range of topics in the natural sciences, including biology, chemistry, earth and environmental sciences, materials science, and physics.

Lipid nanoparticles (LNPs) transport small molecules into the body. The most well-known LNP cargo is mRNA, the key constituent of some of the early vaccines against COVID-19. But that is just one application: LNPs can carry many different types of payload, and have applications beyond vaccines.

Barbara Mui has been working on LNPs (and their predecessors, liposomes) since she was a PhD student in Pieter Cullis’s group in the 1990s. “In those days, LNPs encapsulated anti-cancer drugs,” says Mui, who is currently a senior scientist at Acuitas, the company that developed the LNPs used in the Pfizer-BioNTech mRNA vaccine against SARS-CoV-2. She says it soon became clear that LNPs worked even better as carriers of polynucleotides. “The first one that worked really well was encapsulating small RNAs,” Mui recalls.

But it was mRNA where LNPs proved most effective, primarily because LNPs are comprised of positively charged lipid nanoparticles that encapsulate negatively charged mRNA. Once in the body, LNPs enter cells via endocytosis into endosomes and are released into the cytoplasm. “Without the specially designed chemistry, the LNP and mRNA would be degraded in the endosome,” says Kathryn Whitehead, professor in the departments of chemical engineering and biomedical engineering at Carnegie Mellon University.