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Category: biotech/medical – Page 986

Vaccine for Bee Venom Allergy

Stinging of Hymenoptera can induce IgE-mediated hypersensitivity reactions in patients with venom allergies, ranging from local to severe systemic reactions and even fatal anaphylaxis. Allergic patients’ quality of life can be primarily improved by injecting increased venom doses to alter their immune response to tolerate venom. This venom-specific immunotherapy is very effective and well tolerated, especially in the administration of vaccines. Creative Biolabs is a world leader in the field of vaccine development. With our extensive experience and advanced platform, we are therefore confident in offering the best vaccine development services for allergic disease.

Creative Biolabs provides vaccine development services for bee venom allergy according to customer’s detailed requirements.

Long telomeres, the endcaps on DNA, not the fountain of youth once thought, and scientists may now know why

In a study of 17 people from five families, Johns Hopkins Medicine researchers say they found that ultra-lengthy DNA endcaps called telomeres fail to provide the longevity presumed for such people. Instead, people with long telomeres tend to develop a range of benign and cancerous tumors, as well as the age-related blood condition clonal hematopoiesis.

Reporting in the May 4 issue of the New England Journal of Medicine, the Johns Hopkins researchers say clonal hematopoiesis is common among this long-telomere group, and the blood condition combined with long may help mutations stick around longer in blood cells.

“Our findings challenge the idea that long telomeres protect against aging,” says Mary Armanios, M.D., professor of oncology at the Johns Hopkins Kimmel Cancer Center, and professor of genetic medicine, and genetics, and pathology at the Johns Hopkins University School of Medicine. “Rather than long telomeres protecting against aging, long telomeres allowed cells with mutations that arise with aging to be more durable.”

How interleukin-6 helps prevent allergic asthma and atopy

The immune system has a biological telecommunications system—small proteins known as interleukins that send signals among the leukocyte white blood cells to control their defense against infections or nascent cancer. Interleukin-6, or IL-6, is one of these key mediators of inflammation, and it can, as needed, provoke the immune system into attack against pathogens.

However, imbalances of IL-6—too much or too little—can cause disease, even in the absence of infection. Excess IL-6 is central to the pathogenesis of inflammatory reactions like rheumatoid disease and cytokine storms, while mutations that interrupt IL-6 signaling are also harmful, causing known as atopy that affect the skin, airways or body, including , allergic airway inflammation and hyper-IgE Syndrome, or HIES.

Loss of IL-6 signaling was known to cause an increase in inflammatory T helper 2, or Th2, cells. T helper cells act like generals, ordering other into action. Now, an unrecognized mechanism of how interrupted IL-6 signaling creates Th2 bias, as well as the specific role of IL-6 signaling in that process, has been described by Beatriz Léon, Ph.D., and colleagues at the University of Alabama at Birmingham. Their study is published in Cellular & Molecular Immunology.

From science fiction to reality: Xenobots are redefining biotechnology

The xenobot had been predicted to be a valuable tool in medicine and other fields. It is expected not only to help treat cancer but keep the aquatic bodies clean.

Ever imagined a world where we could utilize the power of a living cell to carry out certain functions? Just like we have robots that help in several aspects of our lives, some scientists in US universities have come up with a living robot known as the xenobot.

The xenobot had been predicted to be a valuable tool in medicine and other fields. In years to come, it wouldn’t only help treat cancer, but it would help keep the aquatic bodies clean.

New drug slows Alzheimer’s

Drug company Eli Lilly reports that donanemab can slow the pace of Alzheimer’s disease by 35%, following a Phase 3 study in human patients.

Brain scans of Alzheimer’s patients with treatment (A and B) and placebo ©, showing clearance of amyloid plaques. Credit: Eli Lilly.

In recent years, Alzheimer’s has become an increasingly major public health issue. The prevalence of this disease – a progressive neurological disorder that affects memory, thinking, and behaviour – is being driven by aging populations, changes in lifestyle factors, and improvements in diagnostic techniques.

A Chance Event 1 Million Years Ago Changed Human Brains Forever

Like treasured recipes passed down from generation to generation, there are just some regions of DNA that evolution doesn’t dare tweak. Mammals far and wide share a variety of such encoded sequences, for example, which have remained untouched for millions of years.

Humans are a strange exception to this club. For some reason, recipes long preserved by our ancient ancestors were suddenly ‘spiced up’ within a short evolutionary period of time.

Because we’re the only species in which these regions have been rewritten so rapidly, they are called ‘human accelerated regions’ (or HARs). What’s more, scientists think at least some HARs could be behind many of the qualities that set humans apart from their close relatives, like chimpanzees and bonobos.

Wonder Material Graphene Just Broke Another Major Record in Physics

Graphene is a special material. Among its many talents, it can act as a superconductor, generate a super-rare form of magnetism, and unlock entirely new quantum states.

Now graphene has another amazing credit: it can record levels of magnetoresistance without a need to push the temperature down towards absolute zero.

High magnetoresistance – a material’s ability to change its electrical resistance in response to a magnetic field – is relatively rare, yet materials that can shift their properties in this fashion are useful in computers, cars, and medical equipment.

Quantifying Biological Age: Blood Test #3 in 2023

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Exercise can increase the number of immune cells in the bloodstream of cancer patients

Exercise decreases the risk of cancer and reduces side effects of cancer treatments. In addition, it improves patients’ quality of life and the prognosis of cancer patients. This is according to two new Finnish studies.

“It was previously thought that cancer patients should just rest after a . Today, we have more and more researched information that can even improve the prognosis of cancer. However, it is not yet fully known how exercise controls cancer,” explains Research Assistant Tiia Koivula.

Previous preclinical studies have found that exercise affects the functioning of the immune system so that more are transferred to the tumor site and they become more active in destroying . Two studies conducted at the Turku PET Center of the University of Turku in Finland aimed to find out whether a short exercise bout affects the mobilization of immune cells in cancer patients.