A recent study identified a non-insulin-related protein that can activate the human insulin receptor, which could lead to the development of an insulin-mimicking oral pill and replace the need for daily injections to treat diabetes.
Category: biotech/medical – Page 937
Many investors are jumping to inject money into the startup.
Bill Gates and Jeff Bezos-backed foundations (Gates Frontier and Bezos Expeditions) have joined other companies in investing $75 million in Synchron, the endovascular brain-computer interface (BCI) company, according to a press release by the organization published on Thursday. This is a Series C financing round led by ARCH Venture Partners that brings the total amount raised since inception to $145 million.
Many investors on board.
Additional companies investing are Reliance Digital Health Limited, Greenoaks, Alumni Ventures, Moore Strategic Ventures, and Project X join ARCH as new additional investors.
The study shows that machine-learning models can help predict COVID-19 infections.
Researchers have discovered a new way to predict which features are most useful in determining test results for COVID-19. The research team, from Florida Atlantic University’s (FAU) College of Engineering and Computer Science in the U.S., used AI to predict positive or negative COVID-19 test results.
The most common techniques currently used to detect COVID-19 are blood tests, also called serology tests, and molecular tests. Since the two assessments use different methods, they vary substantially.
Materials scientists at UNSW Sydney have shown that human pluripotent stem cells in a lab can initiate a process resembling the gastrulation phase—where cells begin differentiating into new cell types—much earlier than occurs in mother nature.
For an embryo developing in the womb, gastrulation occurs at day 14. But in a dish in a lab at UNSW’s Kensington campus, Scientia Associate Professor Kris Kilian oversaw an experiment where a gastrulation-like event was triggered within two days of culturing human stem cells in a unique biomaterial that, as it turned out, set the conditions to mimic this stage of embryo development.
“Gastrulation is the key step that leads to the human body plan,” says A/Prof. Kilian.
Vitamin D plays an important role in the regulation of calcium and phosphorus absorption by the organism. It also helps keep the brain and immune system working. Researchers at the Federal University of São Carlos (UFSCar) in Brazil and University College London (UCL) in the United Kingdom have now shown that vitamin D supplementation reduces the risk of dynapenia in older people by 78%.
Dynapenia is an age-associated loss of muscle strength. It can be partially explained by muscle atrophy and is a major risk factor for physical incapacity later in life. People with dynapenia are more likely to fall, need to go to hospital, be prematurely institutionalized, and die.
An article on the study is published in the journal Calcified Tissue International and Musculoskeletal Research. The study was supported by FAPESP.
In his lively tour of longevity science and pseudoscience, Ward, a British reporter, discovers that researchers are largely not as interested in immortality per se as much as in helping us live fulfilling, active lives until our final day. And while some immortalists hope the culmination of this effort will eventually lead us to never finding that day, Ward leaves the question open.
He begins at the Church of Perpetual Life, a congregation of people who, instead of seeking paradise after death, would rather avoid their demise altogether. There, Ward meets Neal VanDeRee, the church’s pastor, who practices intermittent fasting and envisions a future in which biotechnology advances faster than our bodies break down.
VanDeRee is working to reach what he and other immortalists call “escape velocity” by extending their lives until biotechnology progresses fast enough to keep them alive forever. Another immortalist, Aubrey de Grey, sees this moment as surprisingly close — within 20 to 30 years, or maybe even sooner. It’s quite a claim, but is it possible? “Either we’ll discover we can make people healthy for longer but our lifespan is quite set, as most gerontologists believe, or de Grey’s longevity escape velocity will be proven correct,” Ward writes, never quite telling us which future he is betting on.
American company Pfizer cemented a deal with China to sell its antiviral medication Paxlovid. This is an addition to the supply of Covid treatments in the country. Watch further to know more.
Companies are working to avoid a “quantum winter” that could stall progress and freeze startup investments.
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So we designed CAR-T cells to produce IL-2 using synNotch. Now, when a CAR-T cell encounters a tumor, it produces IL-2 within the tumor instead of outside it, avoiding causing harm to surrounding healthy cells. Because synNotch is able to bypass the barriers tumors put up, it is able to help T cells amp up and maintain the amount of IL-2 they can make, allowing the T cells to keep functioning even in a hostile microenvironment.
We tested our CAR-T cells modified with synNotch on mice with pancreatic cancer and melanoma. We found that CAR-T cells with synNotch-induced IL-2 were able to produce enough extra IL-2 to overcome the tumors’ defensive barriers and fully activate, completely eliminating the tumors. While all of the mice receiving synNotch modified CAR-T cells survived, none of the CAR-T-only mice did.
Furthermore, our synNotch modified CAR-T cells were able to trigger IL-2 production without causing toxicity to healthy cells in the rest of the body. This suggests that our method of engineering T cells to produce this toxic cytokine only where it is needed can help improve the effectiveness of CAR-T cells against cancer while reducing side effects.