Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 785

Recent research published in Nature Communications has used machine learning algorithms to find new compounds that can eliminate senescent cells [1].

Senolytics are molecules that destroy senescent cells. Only a small number of such molecules have been identified, and only two have shown efficacy in clinical trials: dasatinib and quercetin in combination [2]. One of the biggest challenges is that senolytics often only work against specific types of cells. Additionally, some senolytics may work well for one cell type while being toxic to other, non-senescent cell types [3].

There is also a group of senolytics that are used in cancer therapies. However, most of them target pathways that are mutated in cancer. Therefore, they cannot be used as therapeutic agents in different contexts.

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Researchers have long thought that rewards like food or money encourage learning in the brain by causing the release of the “feel-good” hormone dopamine, known to reinforce storage of new information. Now, a new study in rodents describes how learning still occurs in the absence of an immediate incentive.

Led by researchers at NYU Grossman School of Medicine, the study explored the relationship between dopamine and the brain chemical acetylcholine, also known to play a role in learning and memory. Past research had shown that these two hormones compete with one another, so that a boost in one causes a decline in the other. Rewards were thought to promote learning by simultaneously triggering an increase in dopamine and a decrease in acetylcholine.

This sudden hormone imbalance is believed to open a window of opportunity for brain cells to adjust to new circumstances and form memories for later use. Known as neuroplasticity, this process is a major feature of learning as well as recovery after injury. However, the question had remained whether food and other external rewards are the only drivers for this memory system, or whether our brains instead are able to create the same conditions that are favorable to learning without outside help.

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A team from the University of Chicago.

Founded in 1,890, the University of Chicago (UChicago, U of C, or Chicago) is a private research university in Chicago, Illinois. Located on a 217-acre campus in Chicago’s Hyde Park neighborhood, near Lake Michigan, the school holds top-ten positions in various national and international rankings. UChicago is also well known for its professional schools: Pritzker School of Medicine, Booth School of Business, Law School, School of Social Service Administration, Harris School of Public Policy Studies, Divinity School and the Graham School of Continuing Liberal and Professional Studies, and Pritzker School of Molecular Engineering.

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Using machine learning, the system could warn us about the emergence of dangerous virus variants in the future and allow us to prepare in advance.

We all know how devastating the COVID-19 pandemic has been – and it could have been even worse if not for the efforts of scientists and health workers around the world. But what if we could get a heads-up on the next most dangerous variants of a virus before they become a global threat?

Well, a new AI system can just do that. It can warn us about the emergence of dangerous virus variants in future pandemics, according to a study by scientists from Scripps Research and Northwestern University in the US.

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Year 2021 This bit of dna could be synthesized to essentially regrow humans if they had critical injury much like wolverine from the marvel movies.

Two species of sea slugs can pop off their heads and regrow their entire bodies from the noggin down, scientists in Japan recently discovered. This incredible feat of regeneration can be achieved in just a couple of weeks and is absolutely mind-blowing.

Most cases of animal regeneration — replacing damaged or lost body parts with an identical replacement — occur when arms, legs or tails are lost to predators and must be regrown. But these sea slugs, which belong to a group called sacoglossans, can take it to the next level by regrowing an entirely new body from just their heads, which they seem to be able to detach from their original bodies on purpose.

If that wasn’t strange enough, the slugs’ heads can survive autonomously for weeks thanks in part to their unusual ability to photosynthesize like plants, which they hijack from the algae they eat. And if that’s still not enough in the bizarro realm, the original decapitated body can also go on living for days or even months without their heads.

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This is a major crisis in America and most likely globally now.

The US is in the midst of a catastrophic fentanyl epidemic that is causing an eye-watering number of deaths and tearing the fabric of American society apart.

The ultra-strong opioid being cut with virtually every street drug in the country killed a record 75,000 Americans in 2021, the equivalent of 1,500 lives lost every week.

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A protein famed among scientists and clinicians for its ability to suppress the development of many types of tumors may just be moonlighting as a cancer fighter, a recent study by researchers at Stanford Medicine found. The study, conducted in laboratory mice, suggests that the protein, p53, instead evolved to promote the repair of tissues and cells after injury.

The surprising finding is like learning that your favorite bit actor is actually an Oscar-winning director who dabbles in performance on the weekends.

“This turns what we thought we knew about p53 on its head,” said Laura Attardi, Ph.D., professor of radiation oncology and of genetics. “We need to consider that p53’s role as a tumor suppressor may be secondary to a more basic role in repairing damage to tissues.”

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