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Category: biotech/medical – Page 668

Meet pAblo·pCasso: A new leap in CRISPR technologies for next-gen genome engineering

A new CRISPR-Cas toolkit, dubbed “pAblo·pCasso,” is set to transform the landscape of bacterial genome editing, offering unprecedented precision and flexibility in genetic engineering. The new technology, developed by researchers at The Novo Nordisk Foundation Center for Biosustainability (DTU Biosustain), expands the range of genome sites available for base-editing and dramatically accelerates the development of bacteria for a wide range of bioproduction applications.

PAblo·pCasso sets a new standard in CRISPR-Cas technologies. A key innovation is to enable precise and reversible DNA edits within Gram-negative bacteria, a feat not achievable with previous CRISPR systems. The toolkit utilizes specialized fusion enzymes, modified Cas9 coupled with editor modules CBE or ABE, which act like molecular pencils to alter specific DNA nucleotides, thus accurately controlling gene function.

The development of pAblo·pCasso involved overcoming significant challenges. Traditional CRISPR-Cas systems were limited by their need for specific DNA sequences (PAM sequences) near the target site and were less effective in making precise, single-nucleotide changes. pAblo·pCasso transcends these limitations by incorporating advanced Cas-fusion variants that do not require specific PAM sequences, thereby expanding the range of possible genomic editing sites.

Measles Outbreak Should Be a Vaccine Wake-Up Call

Given the value of the vaccine, it’s mindboggling that some in the US would choose not to protect their children. And yet, vaccine rates among US kindergartners fell for the second consecutive year in 2022, a situation the Centers for Disease Control and Prevention said left some 250,000 kids vulnerable to measles. While some of those missed shots were potentially due to challenges accessing timely health care during the pandemic, there’s reason to worry that growing hesitancy about vaccination is also at play.

It does not help that some states are making it easier to forgo routine childhood vaccines. Mississippi, for example, previously led the nation in vaccination coverage for kindergarteners, with more than 98.6% of kids receiving both doses of their MMR shots in the 2021–2022 school year. But anti-vaccine activists succeeded in loosening the state’s childhood vaccination policy, and last year families could for the first time seek religious exemptions for basic shots like MMR, tetanus, polio and others. According to a report from NBC, the state granted more than 2,200 exemptions in the first five months they were allowed.

The shift seemingly reflects a new partisan divide. A recent Pew Research Center poll found a steep drop in the number of Republicans and people who lean Republican who don’t believe vaccines should be required for attending public school.

The Rise of Pico Technology

In the vast realm of scientific discovery and technological advancement, there exists a hidden frontier that holds the key to unlocking the mysteries of the universe. This frontier is Pico Technology, a domain of measurement and manipulation at the atomic and subatomic levels. The rise of Pico Technology represents a seismic shift in our understanding of precision measurement and its applications across diverse fields, from biology to quantum computing. Pico Technology, at the intersection of precision measurement and quantum effects, represents the forefront of scientific and technological progress, unveiling the remarkable capabilities of working at the picoscale, offering unprecedented precision and reactivity that are reshaping fields ranging from medicine to green energy.

Unlocking the Picoscale World

At the heart of Pico Technology lies the ability to work at the picoscale, a dimension where a picometer, often represented as 1 × 10^−12 meters, reigns supreme. The term ‘pico’ itself is derived from the Greek word ‘pikos’, meaning ‘very small’. What sets Pico Technology apart is not just its capacity to delve deeper into smaller scales, but its unique ability to harness the inherent physical, chemical, mechanical, and optical properties of materials that naturally manifest at the picoscale.

Various Eye Diseases Raise Risk for Falls

according to a retrospective cohort study.

Poor vision is associated with risks for falls and fractures, but details about risks associated with specific eye diseases are less clear. In this retrospective U.K. cohort study, researchers identified nearly 600,000 patients (mean age, 74) with cataracts, glaucoma, or age-related macular degeneration (AMD) and compared them with age-and sex-matched control patients who did not have eye diseases. Falls and fractures were tracked for a median of about 4 years. Analyses were adjusted for a wide range of chronic diseases and medications that increase risk for falls.

Compared with controls, patients with eye diseases had significantly higher hazard ratios for falls and fractures: HRs ranged from 1.18 to 1.38 for the three eye-disease groups. The incidence rates for falls per 100,000 person-years were about 1,800 to 2,500 for the three eye-disease groups, compared with 620 to 850 for control groups. For fractures, the corresponding incidence rates for the three eye-disease groups were 970 to 1,290, compared with 380 to 500 for control groups.

The absolute and relative risks for falls and fractures were similar for all 3 eye-disease groups. An unexplained fall, particularly an injurious one, should prompt primary care clinicians to explore visual impairment as a potential cause or contributing factor.

Fantastic Voyage: Cancer Tumors Reduced by 90% Using Nanorobots

The research, which was conducted on mice, demonstrates how these tiny nanomachines are propelled by urea present in urine and precisely target the tumor, attacking it with a radioisotope carried on their surface.

Bladder cancer has one of the highest incidence rates in the world and ranks as the fourth most common tumor in men. Despite its relatively low mortality rate, nearly half of bladder tumors resurface within 5 years, requiring ongoing patient monitoring. Frequent hospital visits and the need for repeat treatments contribute to making this type of cancer one of the most expensive to cure.

While current treatments involving direct drug administration into the bladder show good survival rates, their therapeutic efficacy remains low. A promising alternative involves the use of nanoparticles capable of delivering therapeutic agents directly to the tumor. In particular, nanorobots—nanoparticles endowed with the ability to self-propel within the body—are noteworthy.