Lifeboat Foundation

This impressive achievement could potentially revolutionize how we treat cancer and immunity deficiencies.

Children born with Artemis-SCID face many challenges, from a missing repertoire of T and B cells to reduced resistance against chemotherapy used in bone marrow transplants. Additionally, malfunctioning DNA repair mechanisms increase the risk of developing graft-versus-host disease, where the donor’s immune system attacks host tissues.

That’s why researchers are trying everything to find an antidote for such a rare genetic disease and have now turned to gene therapy to treat Artemis-SCID. Gene therapy eliminates the need for donor cells.

Continue reading “Gene therapy could save children from a rare genetic disease” »

A new study develops ‘environment-modulating’ drugs that reinvigorate T-cells to once again destroy cancer cells.

T-cells, typically thought to be anti-cancer, can switch sides and work against us in the right environment (or battlefield!), according to a new study published on December 21 in Nature.

This discovery is unexpected because many extensive studies before this believed that most worn-out T-cells’ properties were “irreversible.” Simply put, they were doomed to being subpar tumor killers.

Continue reading “Scientists break new ground in cancer fight by ‘reinvigorating’ T cells” »

The deadly brain cancer is no longer a mystery.

Glioblastoma is one of the most dangerous cancer types affecting the human brain and spinal cord. Over 240,000 people lose their lives because of nervous system cancer annually, and in most of these cases, the leading cause of death is glioblastoma.

Its tumors spread fast and induce highly painful seizures and headaches. What’s worse is that there is no known 100 percent effective cure for this disease. US president Joe Biden’s eldest son Beau Biden and late American actor Robert Forster were also among the many victims of glioblastoma.

The newly-created Longevity Escape Velocity Foundation (LEV) has released details of the first study in its flagship research programme: Robust Mouse Rejuvenation – Study 1.

Longevity. Technology: A highlight of Longevity Summit Dublin 2022 was Dr Aubrey de Grey’s announcement of his new foundation; LEV Foundation exists to proactively identify and address the most challenging obstacles on the path to the widespread availability of genuinely effective treatments to prevent and reverse human age-related disease, and to that end, its flagship research programme is a sequence of large mouse lifespan studies.

Mouse models are significant in aging research for several reasons. Mice and humans share many genetic and physiological similarities, including similar aging-related pathways, and this makes mice a useful model for studying the molecular and cellular processes underlying aging in humans.

Compounds in final-stage trials at Eli Lilly and Eisai may halt brain protein buildup linked to cognitive decline.

𝐀𝐥𝐳𝐡𝐞𝐢𝐦𝐞𝐫’𝐬 𝐃𝐢𝐬𝐞𝐚𝐬𝐞

One of the main features of Alzheimer’s disease is that the β-amyloid peptide, a molecule found inside neurons that has many diverse functions, begins to fold incorrectly and accumulates. This process, which ends up causing neuronal death, is linked to a series of other cellular alterations, making it difficult to determine whether they are the cause or the consequence. An example is the case of the deregulation of a type of dynorphin.

Dynorphins are the body’s own opioid peptides, which play a key role in many brain pathways. They are located in different areas of the brain, such as the hippocampus, amygdala or hypothalamus, and are involved in memory processes, emotion control, stress and pain, and among other processes. In addition, several studies have shown their involvement in epilepsy, stroke, addictions, depression and schizophrenia.

Continue reading “Big dynorphin may protect neurons from the accumulation of Alzheimer’s-associated amyloid” »

The Chinese subvariant Omicron BF.7 has reached India. 3 cases have been reported so far, 2 in Gujarat & 1 in Odisha. The Niti Aayog says there’s no need to panic. But if the situation escalates, Is India prepared? Here’s what Priyanka Sharma has to say.
#china #covid #wion.

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Continue reading “Gravitas: Wuhan Virus returns: Is India prepared?” »

Laser technician Denise Sediq prepares the right eye of Lt. Colonel Thomas Hite, Jr. for corrective eye surgery at Walter Reed Army Medical Center June 11, 2002 in Washington, DC. (Photo by Stefan Zaklin/Getty Images)

The federal agency has issued a 25-page draft report outlining how doctors should better inform patients about the potential for double vision, dry eyes, poor night vision, eye pain and other side effects after LASIK surgery.

“This concept that cells ‘fight back’ against modified RNA is of practical importance, as it suggests how one might improve the effectiveness of RNA therapy.”

Researchers from the Smidt Heart Institute have unveiled a novel concept — they harnessed modified messenger RNA (mRNA) technology used in creating the Pfizer and Moderna Covid-19 vaccines, which can be a significant step in the evolution and creation of biological pacemakers.

Luismmolina/iStock.

Continue reading “A breakthrough in mRNA therapies could lead to biological heart pacemakers” »