Lifeboat Foundation

An antibiotic developed some 80 years ago before being abandoned and forgotten could again offer exciting new solutions, this time to the emerging threat of drug-resistant superbugs.

Half of the bacteria-killing drugs we use today are variations of compounds that were found nearly a century ago, during this ‘golden age’ of antibiotics. One called streptothricin was isolated in the 1940s, drawing attention for its potential in treating infections caused by what are known as gram-negative bacteria.

Unlike gram-positive bacteria, these microbes lack a robust cell wall that many antibiotics target. Finding alternatives has been one of the big challenges for the pharmaceutical industry. In 2017, the World Health Organization (WHO) released a list of the most dangerous, drug-resistant pathogens out there. Most were gram-negative bacteria.

Closin in on Doctor jobs.

A medical domain AI developed by Google Researchers broke records on its ability to pass medical exam questions, but more surprisingly generated answers that were consistently rated as better than human doctors. While the study notes several caveats, it marks a significant milestone in how AI could upend a number of professions.

Fitbits and Apple Watches weren’t designed for people with atypical health conditions. But the tech can be extremely useful—with some creativity.

Evidence that non-invasive sensory stimulation of 40 Hz gamma frequency brain rhythms can reduce Alzheimer’s disease pathology and symptoms, already shown with light and sound by multiple research groups in mice and humans, now extends to tactile stimulation. A new study by MIT scientists shows that Alzheimer’s model mice exposed to 40 Hz vibration an hour a day for several weeks showed improved brain health and motor function compared to untreated controls.

The MIT group is not the first to show that gamma frequency tactile stimulation can affect brain activity and improve motor function, but they are the first to show that the stimulation can also reduce levels of the hallmark Alzheimer’s protein phosphorylated tau, keep neurons from dying or losing their synapse circuit connections, and reduce neural DNA damage.

“This work demonstrates a third sensory modality that we can use to increase gamma power in the brain,” said Li-Huei Tsai, corresponding author of the study, director of The Picower Institute for Learning and Memory and the Aging Brain Initiative at MIT, and Picower Professor in the Department of Brain and Cognitive Sciences (BCS).

Cardiovascular diseases, such as heart attacks, are a leading cause of death worldwide resulting from a limited self-healing power of the heart. Unlike humans, zebrafish have the remarkable capacity to recover from cardiac damage. Researchers from the group of Jeroen Bakkers (Hubrecht Institute) have used the zebrafish to shed light on their regenerative success. They discovered a new mechanism that functions as a switch to push the heart muscle cells to mature in the regeneration process. Importantly, this mechanism was evolutionary conserved as it had a very similar effect on mouse and human heart muscle cells.

The results of the study, published in Science on May 18, show that examining the natural heart regeneration process in zebrafish and applying these discoveries to human heart muscle cells could contribute to the development of new therapies against cardiovascular diseases.

Continue reading “How to repair a damaged heart: Key mechanism behind heart regeneration in zebrafish revealed” »

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Researchers are working on edible computer chips to control robots that can operate inside the human body to precisely deliver drugs before safely being digested.

By Matthew Sparkes

Continue reading “Edible computer chips could control digestible drug-delivery robots” »

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The genetically modified super-smart mice also proved to suffer less from anxiety, the scientists found.

For all that science has decoded the human genome, we don’t actually know what most of our DNA does, or even what a great many of our genes do. One way to elucidate what a gene does is to change it (mutate it) and see what happens.

Continue reading “Scientists create super-intelligent mice, discover they’re also very laid-back” »

(https://isbscience.org/bio/leroy-hood/) is Co-Founder, Chief Strategy Officer and Professor, at the Institute of Systems Biology (ISB) in Seattle, as well as CEO of Phenome Health (https://phenomehealth.org/), a nonprofit organization dedicated to delivering value through health innovation focused on his P4 model of health (Predictive, Preventive, Personalized and Participatory) where a patient’s unique individuality is acknowledged, respected, and leveraged for the benefit of everyone.

Dr. Hood, who is a world-renowned scientist and recipient of the National Medal of Science in 2011, co-founded the Institute for Systems Biology (ISB) in 2000 and served as its first President from 2000–2017. In 2016, ISB affiliated with Providence St. Joseph Health (PSJH) and Dr. Hood became PSJH’s Senior Vice President and Chief Science Officer.

Continue reading “Dr. Leroy Hood, MD, Ph.D. — Co-Founder, Institute of Systems Biology (ISB); CEO, Phenome Health” »

Imagine using your cellphone to control the activity of your own cells to treat injuries and disease. It sounds like something from the imagination of an overly optimistic science fiction writer. But this may one day be a possibility through the emerging field of quantum biology.

Over the past few decades, scientists have made incredible progress in understanding and manipulating biological systems at increasingly small scales, from protein folding to genetic engineering. And yet, the extent to which quantum effects influence living systems remains barely understood.

Continue reading “Quantum physics proposes a new way to study biology—the results could revolutionize our understanding of how life works” »