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Hi everybody. I’m writing to you because we are reaching an important moment in our reproduction of Harold Katcher’s seminal study of rats rejuvenation, in which we are only 9 months from starting the injections but we raised 71% of the total cost of the experiment. We already published the article of our 2024 experiment in a peer-reviewed journal (https://journals.tmkarpinski.com/index.php/ejbr/article/view/772), in which we injected the Pig Plasma Extracellular Particles (PPEPs) in young rats to assess a potential acute immunogenicity or toxicity — without any negative effect observed. Nina Torres Zanvettor (cofounder of ICR together with me) and I were interviewed some weeks ago by Eleanor Sheekey in her YouTube channel (https://youtu.be/Q-lS1UMHG1o?si=ImDWycjM8r8-KpyF), as we are trying to spread the word about the experiment and the crowdfunding. We are making the experiment in collaboration with Unicamp university and Dr. Marcelo Mori, a world-class aging scientist. The rats are already aging in the university facility and we are preparing the epigenetic age measurements with Horvath’s foundation (Clock Foundation), but we still have to raise 29% (US$21,000) of the total cost (US$75,000).

(https://youtu.be/Q-lS1UMHG1o

We will publish everything (methods, materials and results) immediately, but we need the help of the community too, as we will give back all the information for the community. Could you help us to fund the study? Any amount is important. The link to make a donation is https://www.rejuvenescimento.org/donation. I don’t even consider it precisely a “donation”, but a financial collaboration, as the “donor” would be able to use the information, and maybe they can also use the rejuvenation technology that some day would arise from this research. By the way, if we manage to rejuvenate the rats, we will then try to keep them young as long as we can, in a longevity experiment. Also, if we rejuvenate the rats, we will carry out a safety experiment in a Good Laboratory Practices facility here in Brazil that would allow regulatory approval to try the therapy in human patients who don’t have any other alternative to be kept alive — we expect to be able to carry out those human trials in 2028. So we intend to go all the way to the clinic, if we confirm Katcher’s results.

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Spider-inspired magnetic soft robots could perform minimally invasive gastrointestinal tract procedures

The gastrointestinal (GI) tract is a collection of organs and structures inside the bodies of humans and other animals that is responsible for the digestion of food, the absorption of nutrients and the expulsion of waste. Its underlying parts include the mouth, esophagus, stomach, intestines, rectum and anus.

Over the past decades, the incidence of cancer in the GI tract and some other conditions affecting the digestive system has risen substantially. Existing approaches to diagnose and treat GI cancers rely on endoscopy, a medical procedure that entails the inspection of internal organs via a flexible tube with an embedded camera (i.e., endoscope), which is inserted into the body through the anus, mouth or a small incision.

In addition to being highly uncomfortable for patients, endoscopy often fails to reach regions that are deep into the GI tract or are difficult to access due to the body’s natural configuration. Some have thus been trying to devise alternative systems that could inspect parts of the digestive system more effectively, while causing patients minimal discomfort.

Anti-ageing and increased mental capacity through cannabis

A low-dose long-term administration of cannabis can not only reverse aging processes in the brain, but also has an anti-aging effect. Researchers from the University Hospital Bonn (UKB) and the University of Bonn together with a team from Hebrew University (Israel) have now been able to show this in mice. They found the key to this in the protein switch mTOR, whose signal strength has an influence on cognitive performance and metabolic processes in the entire organism. The results are now presented in the journal “ACS Pharmacology & Translation Science”

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If quantum computing is answering unknowable questions, how do we know they’re right?

Quantum computing promises to solve the seemingly unsolvable in fields such as physics, medicine, cryptography and more.

But as the race to develop the first large-scale, error-free commercial device heats up, it begs the question: how can we check that these ‘impossible’ solutions are correct?

A new Swinburne study is tackling this paradox. The paper is published in the journal Quantum Science and Technology.

A biocompatible and stretchable transistor for implantable devices

Recent technological advances have opened new possibilities for the development of advanced biomedical devices that could be implanted inside the human body. These devices could be used to monitor biological signals that offer insight about the evolution of specific medical conditions or could even help to alter problematic physiological processes.

Despite their potential for the diagnosis and treatment of some conditions, most developed to date are based on rigid electronic components. These components can damage tissue inside the body or cause inflammation.

Some have been trying to develop alternative implantable electronics that are based on soft and stretchable materials, such as polymers. However, most known polymers and elastic materials are not biocompatible, which means that they can provoke immune responses and adversely affect the growth of cells.

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