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Category: biotech/medical – Page 571

Delivering high-quality mRNA using enzymes: A guide to mRNA in vitro transcription

From being a promising yet underexplored approach in the 1990s, mRNA therapeutics have evolved dramatically. The discovery of chemical modifications to overcome mRNA’s instability and immunotoxicity enabled these therapeutics to reach clinical trials and the forefront of modern medicine. The platform’s scalability, rapid production and relatively straightforward manufacturing process mean that mRNA therapeutics are a powerful alternative to traditional small molecule drugs and DNA technology.

Enzymes are a vital tool that make in vitro transcription possible and refine the reaction products to generate highly pure, homogeneous mRNA. In this ebook, we provide an in-depth review into:

Researchers develop T cell growth method that enhances cancer-fighting ability in melanoma model

Experimental findings indicated that activating T cells for 48 hours in combination of certain stimuli could encourage aerobic glycolysis. The highest level of aerobic glycolysis was noted with a combination of three stimuli, namely T cell receptor (TCR) triggering, CD28 costimulation, and hyper-physiologic concentrations of IL-2.

To generate an ‘‘in vivo-activated’’-like state and enhance efficacy, freshly isolated TCR-Tg pmel-1 CD8+ T cells were activated using antigen-presenting cells, cognate peptide (gp100), and IL-2. A 7-day T cell conditioning with DCA reduced extracellular lactate and increased total acetyl-coenzyme A (CoA) by changing glycolytic flux.

To assess the effects of DCA conditioning on the potency of therapeutic T cells in cancer immunotherapy, these cells were used to treat mice bearing B16 melanoma. Cytotoxicity assays showed a small but significant improvement in the therapeutic potential of DCA-conditioned T cells.

My Top 4 Promising Technologies for Extending Healthspan

BiOptimizers Magnesium Breakthrough 10% with code Modern10 https://bioptimizers.com/modern. This video brought to you by BiOptimizers.
Here I look at which technologies I think could make a difference in healthspan and lifespan in the next 5 to 10 years.
Some links are affiliate links so we will earn a commission when they are used to purchase products.

If you would like to support our channel please consider joining our patreon / modernhealthspan.
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Metabolic Daily https://pendulumtherapeutics.sjv.io/N… 5% discount Code MODERN https://omegaquant.com/shop/ Bulletproof 15% off with coupon code: HEALTHSPAN15: https://tinyurl.com/4npjk5vp Inner Fuel Gut support https://bulletproof.fdf2.net/PyDKDM Omega-3 Krill Oil https://bulletproof.fdf2.net/xkdxmy Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN OneSkin 15% Discount: Code MODERN https://tinyurl.com/3t6tevj8 OS-01 Face Topical Supplement https://tinyurl.com/29c8wrr2 ☕If you would like to support our channel, we’d love a coffee…thank you! https://www.buymeacoffee.com/mhealthspan Chapters 00:00 Intro 03:36 Dr Greg Fahy Thymus regeneration 15:24 BiOptimizers 16:46 Dr Harold Katcher Young Porcine Exosomes 19:40 Nicolas & Nina Taking Dr Katcher’s results to clinical trials 22:48 Dr Hans Keirstead Stem cell secretome 29:50 Tom Benson Mitochondrial transplants 37:30 Dr Alessio Lanna Rejuvenating the immune system 🌐Links in this video *************************************** Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation. Audio Copyright Disclaimer Please note that we have full authorization to the music that we used in our videos as they were created using the service WeVideo which provides the rights to the music. The rights are detailed in the terms of use that can be reviewed here https://www.wevideo.com/terms-of-use and any following inquiries should be addressed to [email protected]. ********************************************** #stemcells #mitochondria #immunesystem.
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Chapters.
00:00 Intro.
03:36 Dr Greg Fahy Thymus regeneration.
15:24 BiOptimizers.
16:46 Dr Harold Katcher Young Porcine Exosomes.
19:40 Nicolas & Nina Taking Dr Katcher’s results to clinical trials.
22:48 Dr Hans Keirstead Stem cell secretome.
29:50 Tom Benson Mitochondrial transplants.
37:30 Dr Alessio Lanna Rejuvenating the immune system.

🌐Links in this video.

*******************************
Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation.

Audio Copyright Disclaimer.

Continue reading “My Top 4 Promising Technologies for Extending Healthspan” | >

Why your brightly coloured food can hold some dark secrets

Artificial food colours — the kind you find in candies, drinks and processed meats — are now under international scrutiny for possibly causing cancer, allergic reactions and behavioural issues. What can you do to keep your food safe?

There’s something undeniably attractive about the colour red. It’s powerful, bold and assertive on the lips; appetising in food and on restaurant billboards; and certainly hard to miss on a traffic signal — or so we’d hope!

Rapamycin Rejuvenates The Immune System (Clip)

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Voice AI Startup ElevenLabs Hit $3.3 Billion Valuation After Latest Funding Round

In today’s AI news, ElevenLabs said on Thursday it has raised $180 million in a new funding round that triples the voice cloning artificial intelligence startup’s valuation to $3.3 billion. The Series C funding round was co-led by Andreessen Horowitz and Iconiq Growth, with participation from additional new investors.

On Thursday, OpenAI announced that it is deepening its ties with the US government through a partnership with the National Laboratories and expects to use AI to “supercharge” research across a wide range of fields to better serve the public.

“This is the beginning of a new era, where AI will advance science, strengthen national security, and support US government initiatives,” OpenAI said.

In other advancements, Cerebras Systems announced today it will host DeepSeek’s breakthrough R1 artificial intelligence model on U.S. servers, promising speeds up to 57 times faster than GPU-based solutions while keeping sensitive data within American borders. The move comes amid growing concerns about China’s rapid AI advancement and data privacy.

And, the US Copyright Office issued AI guidance this week that declared no laws need to be clarified when it comes to protecting authorship rights of humans producing AI-assisted works. “Questions of copyrightability and AI can be resolved pursuant to existing law, without the need for legislative change,” the Copyright Office said.

In videos, let’s bust some early myths about DeepSeek. In episode 40 of Mixture of Experts, join host Tim Hwang along with experts Aaron Baughman, Chris Hay and Kate Soule. Last week, we covered the release of DeepSeek-R1; now that the entire world is up to speed, let’s separate the facts from the hype. Next, what is model distillation and why does it matter for competition in AI?

Then, recorded at TEDAI Vienna, AI researcher Youssef Nader and digital archaeologist Julian Schilliger share how they used AI to virtually “unroll” and decode the Herculaneum scrolls, burnt and buried by the eruption of Mount Vesuvius nearly 2,000 years ago. Learn how AI could help decipher a range of artifacts, revealing clues about the mysteries and achievements of the ancient world. And, the native 1080p AI Video from Pika can create hyper-realistic animals. Jerrod Lew is back with another demo of Pika 2.1 generating animals with text-to-video prompts.

Continue reading “Voice AI Startup ElevenLabs Hit .3 Billion Valuation After Latest Funding Round” | >

Artificial organic neuron closely mimics the characteristics of biological nerve cells

Researchers at Linköping University (LiU), Sweden, have created an artificial organic neuron that closely mimics the characteristics of biological nerve cells. This artificial neuron can stimulate natural nerves, making it a promising technology for various medical treatments in the future.

Work to develop increasingly functional artificial continues at the Laboratory for Organic Electronics, LOE. In 2022, a team of scientists led by associate professor Simone Fabiano demonstrated how an artificial organic neuron could be integrated into a living carnivorous plant to control the opening and closing of its maw. This synthetic nerve cell met two of the 20 characteristics that differentiate it from a biological nerve cell.

In their latest study, published in the journal Nature Materials, the same researchers at LiU have developed a new artificial nerve cell called conductance-based organic electrochemical neuron, or c-OECN, which closely mimics 15 out of the 20 neural features that characterize biological nerve cells, making its functioning much more similar to natural nerve cells.

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