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Category: biotech/medical – Page 554

Cocaine use continues to be a public health problem, yet despite concerted efforts, no drugs have been approved to resolve cocaine addiction. Research suggests that the attention-deficit/hyperactivity disorder drug methylphenidate (MPH; Ritalin) could serve as a cocaine-replacement therapy, but clinical results have been mixed. Although several labs have produced MPH derivatives for testing, parts of the molecule remained chemically inaccessible. Now, researchers reporting in ACS Central Science have cleared that hurdle.

According to the Centers for Disease Control and Prevention, more than 5 million Americans reported actively using cocaine in 2020, and almost 25,000 Americans died of a cocaine-related overdose in 2021. Although small-molecule drugs have proven effective in treating other drug addictions—for example, methadone as a therapy for heroin abuse—no such medication exists for cocaine abuse.

MPH has been considered a potential treatment because it behaves similarly to the illicit drug, increasing dopamine levels in the brain by blocking dopamine reuptake. Additionally, have shown that MPH has a lower risk of abuse than cocaine.

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Bacterial diversity in the gut plays an important role in health. The human microbiome has featured prominently in research, with links being made between it and cancer, personality, memory, and diseases such as diabetes and multiple sclerosis.

While it’s understood that a mother’s microbiome is transferred to their baby at birth and boosted by breastfeeding, what other sources of gut bacteria are there? A new study by researchers at the Graz University of Technology (TU Graz) in Austria has confirmed, for the first time, that one source is fruits and vegetables.

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The human gut microbiome has a crucial connection to our health and well-being, but it is a complex entity made up of many different organisms, which all have an effect on one another. The hundreds of different microbial species in the gut metabolize the foods we consume in different ways, and the metabolites that microbes generate are often then consumed by other microbes. It’s been suggested that the more than half of the stuff that is eaten by gut microbes are byproducts of other gut microbes. This interdependence can have profound implications for the gut microbiome, and some species become totally reliant on the presence of others.

Scientists are still learning about the various characteristics of a healthy human gut microbiome, but there are certain species that tend to be present. High diversity in the microbiome is also typically associated with good health. While some microbes can fill in the gaps if other important ones are missing, some species can’t be substituted.

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It’s the day after the Baltimore Orioles clinched the American League East Championship with their 100th win of the season, and lifelong fan Tim Evans is showing his pride on his sleeve.

“It’s so great,” Evans, 62, says with a huge smile, wearing his orange O’s jersey.

The last time the Orioles won the AL East was in 2014, the same year Evans was diagnosed with amyotrophic lateral sclerosis (ALS), a progressive nervous system disease that causes muscle weakness and loss of motor and speech functions. Evans currently has severe speech and swallowing problems. He can talk slowly, but it’s hard for most people to understand him.

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A study spearheaded by Oregon State University has shown why certain polyunsaturated fatty acids work to combat a dangerous liver condition, opening a new avenue of drug research for a disease that currently has no FDA-approved medications.

Scientists led by Oregon State’s Natalia Shulzhenko, Andrey Morgun and Donald Jump used a technique known as multi-omic network analysis to identify the mechanism through which dietary omega 3 supplements alleviated nonalcoholic steatohepatitis, usually abbreviated to NASH.

The mechanism involves betacellulin, a protein growth factor that plays multiple positive roles in the body but also contributes to , or scarring, and the progression to cirrhosis and .

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Magnets are magnificent. Made of iron, aluminum, nickel, cobalt, and various other metals, they’re used in compasses for navigation, in medical imaging machines to see inside the human body, in kitchens to keep cabinets and refrigerators closed, in computers to store data and in new high-speed “hyperloop” trains that can travel at speeds of up to 76 miles per hour.

For environmentalists, however, the most exciting use yet for magnets might be a newly discovered application out of Australia’s Royal Melbourne Institute of Technology, otherwise known as RMIT University: Using magnets, researchers there have discovered a novel way of removing harmful microplastics from water.

“[Microplastics] can take up to 450 years to degrade, are not detectable and removable through conventional treatment systems, resulting in millions of tons being released into the sea every year,” co-lead research Nasir Mahmood said in a statement. “This is not only harmful for aquatic life, but also has significant negative impacts on human health.”

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🦠🔬💊 https://www.news-medical.net/news/20231025/How-strep-bacteri…-treatment

Researchers discover that Group A streptococcal infections alter immunoglobulin G (IgG) homeostasis to evade the immune system, affecting the transition from local to systemic infections. The study also raises concerns about the effectiveness of antibody-based therapies, as the bacteria’s virulence factors can degrade therapeutic antibodies.

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Researchers at Baylor College of Medicine have identified a small molecule named 5D4 that can suppress the growth of breast and ovarian cancers in animal models. 5D4 works by binding to TopBP1 protein in cancer cells, disrupting its interactions with several pathways that promote cancer growth. Combining 5D4 with another cancer inhibitor, talazoparib, enhances the effectiveness of the anti-cancer activity.

The study, published in the Proceedings of the National Academy of Sciences, strongly supports continuing the investigation toward further developing this strategy for clinical use.

“Cancer development involves many steps of genetic alterations and signaling pathway deregulation. About 10 years ago, our team discovered that protein TopBP1 is at a convergent point of multiple cellular pathways involved in cancer growth and progression, making it a potential candidate for targeted cancer therapy,” said corresponding author Dr. Weei-Chin Lin, professor of medicine-hematology and oncology and of molecular and cellular biology at Baylor. He also is a member of Baylor’s Dan L Duncan Comprehensive Cancer Center. “Our idea was to identify molecules that would bind to TopBP1 and interfere with its interactions with molecular pathways that promote cancer growth.”

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The liver is one of the largest organs in the body. The main types of liver cancer in adults are hepatocellular carcinoma and bile duct cancer, or cholangiocarcinoma. Read our expert-reviewed summary of these diseases.

Primary liver cancer is a disease in which cancer forms in the liver. The most common type is hepatocellular carcinoma. Learn more about liver cancer, signs, and symptoms from the National Cancer Institute.

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A new study shows that cerebrospinal fluid reduces current treatment efficacy in brain cancer and identifies new therapeutic opportunities.

Cerebrospinal fluid, the clear colorless liquid that protects the , also may be a factor that makes brain cancers resistant to treatment, Australian researchers led by Associate Professor Cedric Bardy at the South Austraila Health and Medical Research Institute (SAHMRI) and Flinders University reveal in the journal Science Advances.

Reporting how this occurs, the study, titled “Human cerebrospinal fluid affects chemoradiotherapy sensitivities in tumor cells from patients with ,” in Science Advances shows that a decades-old anti-anxiety drug can improve the effectiveness of chemo-radiotherapy towards glioblastoma, or GBM, the most common and lethal .

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