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Category: biotech/medical – Page 507

Altos rejuvenation research in mice signposts healthspan extension

So, they get very healthy but only live 24% longer no matter how many more times they use the treatment. I wonder what the telomere effect is. And what they are doing is not the same as what Aubrey’s mouse experiment is doing.

Altos Labs Co-founder and Chief Scientist Rick Klausner participated in a panel discussing efforts to increase human healthspan by combatting age-related diseases at this year’s Aspen Ideas Health conference.

In a panel that included Laura Deming and Kristen Fortney, Klausner discussed an Altos experiment in Spain (likely to be research conducted by Universidad Católica de Murcia and Altos Labs in collaboration with the Hospital Clínic de Barcelona), Klausner reported that if old kidneys are transplanted into young people they do not function nearly as well as transplanting young kidneys – but organ donations donors are getting older and older, and therein lies the rub.

We’ve been doing these experiments with the transplant team at Barcelona where we remove a kidney from different animals, and now we’re preparing to do this in the clinic. You take an old kidney and you transplant it into a young rat versus [transplanting] a young kidney and you see a tremendous difference in overall survival and kidney function. But when we take the old rat organ and we introduce these components that rejuvenate, this reprogramming cocktail, just for 45 minutes they’re exposed to it and then they survive as well if not better than the young organs that are transplanted.

Sugar Substitute Linked to Increased Risk of Heart Attack and Stroke, study finds

Xylitol is a common zero-calorie sweetener found in sugar-free candy and toothpaste. Cleveland Clinic researchers found higher amounts of the sugar alcohol xylitol are associated with increased risk of cardiovascular events like heart attack and stroke.

The team, led by Stanley Hazen, M.D., Ph.D., confirmed the association in a large-scale patient analysis, preclinical research models and a clinical intervention study. Findings were published today in the European Heart Journal.

Xylitol is a common sugar substitute used in sugar-free candy, gums, baked goods and oral products like toothpaste. Over the past decade, the use of sugar substitutes, including sugar alcohols and artificial sweeteners, has increased significantly in processed foods that are promoted as healthy alternatives.

Chinese researchers develop first open-source brain-on-chip interface system globally

Chinese researchers have developed an open-source “brain-on-chip” interface system, which is the first of its kind in the world. The system can instruct a robot to avoid obstacles, track, and grasp through “mind control,” the Science and Technology Daily reported on Wednesday.

The interface system was co-developed by research teams from Tianjin University and Southern University of Science and Technology.

The system uses an artificial brain cultivated in vitro – such as a “brain-like organ,” which can interact with external information through encoding, decoding and stimulus-feedback when coupled with electrode chips, according to the report.

AI Super-Human Eye Brings Scientists One Step Closer to Understanding the Most Complicated and Mysterious Dimension of Our Existence

The brain is the most complex organ ever created. Its functions are supported by a network of tens of billions of densely packed neurons, with trillions of connections exchanging information and performing calculations. Trying to understand the complexity of the brain can be dizzying. Nevertheless, if we ever hope to understand how the brain works, we need to be able to map neurons and study how they are wired.

Now, publishing in Nature Communications, researchers from Kyushu University have developed a new AI tool, which they call QDyeFinder, that can automatically identify and reconstruct individual neurons from images of the mouse brain. The process involves tagging neurons with a super-multicolor labeling protocol, and then letting the AI automatically identify the neuron’s structure by matching similar color combinations.

Engineers find a way to protect microbes from extreme conditions

Microbes that are used for health, agricultural, or other applications need to be able to withstand extreme conditions, and ideally the manufacturing processes used to make tablets for long-term storage. MIT researchers have now developed a new way to make microbes hardy enough to withstand these extreme conditions.

Their method involves mixing bacteria with food and drug additives from a list of compounds that the FDA classifies as “generally regarded as safe.” The researchers identified formulations that help to stabilize several different types of microbes, including yeast and bacteria, and they showed that these formulations could withstand high temperatures, radiation, and industrial processing that can damage unprotected microbes.

In an even more extreme test, some of the microbes recently returned from a trip to the International Space Station, coordinated by Space Center Houston Manager of Science and Research Phyllis Friello, and the researchers are now analyzing how well the microbes were able to withstand those conditions.

AGI-23 | Test and Evaluation First Principles for General Learning Systems

This is a recording of the AGI23 Conference, Day 1, June 16th 2023, Stockholm. This video shows the following tutorial: Test and Evaluation First Principles for General Learning Systems, led by Tyler Cody.

SingularityNET was founded by Dr. Ben Goertzel with the mission of creating a decentralized, democratic, inclusive, and beneficial Artificial General Intelligence (AGI). An AGI is not dependent on any central entity, is open to anyone, and is not restricted to the narrow goals of a single corporation or even a single country.

The SingularityNET team includes seasoned engineers, scientists, researchers, entrepreneurs, and marketers. Our core platform and AI teams are further complemented by specialized teams devoted to application areas such as finance, robotics, biomedical AI, media, arts, and entertainment.

Website: https://singularitynet.io.
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Instagram: / singularitynet.io.
Discord: / discord.
Forum: https://community.singularitynet.io.
Telegram: https://t.me/singularitynet.
WhatsApp: https://whatsapp.com/channel/0029VaM8…
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Github: https://github.com/singnet.
Linkedin: / singularitynet.

Genomic variants study points to improved detection of thyroid cancer

Researchers from Sinai Health and the University of Toronto have gleaned new insights into how thyroid cancer could be more effectively treated.

The study, which looked at thyroid tumor tissues and thyroid nodule biopsies from 620 patients at Mount Sinai Hospital from 2016 to 2022, examined whether differences in patients’ RAS genomic variants were reflected in the status of their tumors. It also investigated the presence of the variant BRAF V600E and TERT promoter variants in the patient’s samples.

Researchers ultimately concluded that differences in RAS in combination with BRAF V600E and TERT promoter variants could be used to arrive at more accurate cancer diagnoses in patients with indeterminate thyroid nodules.

Re-engineering cancerous tumors to self-destruct and kill drug-resistant cells

Treating cancer can sometimes feel like a game of Whac-A-Mole. The disease can become resistant to treatment, and clinicians never know when, where and what resistance might emerge, leaving them one step behind. But a team led by Penn State researchers has found a way to reprogram disease evolution and design tumors that are easier to treat.

They created a modular genetic circuit that turns cancer cells into a “Trojan horse,” causing them to self-destruct and kill nearby drug-resistant cancer cells. Tested in human cell lines and in mice as proof of concept, the circuit outsmarted a wide range of .

The findings were published today, July 4, in the journal Nature Biotechnology. The researchers also filed a provisional application to patent the technology described in the paper.