Cleveland Clinic researchers have discovered a new bacterium that weakens the immune system in the gut, potentially contributing to certain inflammatory and infectious gut diseases.
The team identified the bacterium, Tomasiella immunophila (T. immunophila), which plays a key role in breaking down a crucial immune component of the gut’s multi-faceted protective immune barrier.
Identifying this bacterium is the first step to developing new treatments for a variety of inflammatory and infectious gut diseases. These conditions, including inflammatory bowel disease, Crohn’s and ulcerative colitis, are associated with decreased levels of secretory immunoglobulin A (SIgA), an antibody that protects mucosal surfaces.
Source: Nottingham Trent University.
Scientists have identified previously unreported genes which appear to play a key role in the muscle aging process. It is hoped that the findings from a Nottingham Trent University study could be used to help delay the impact of the aging process.
The study, which also involved Sweden’s Karolinska Institute, Karolinska University Hospital, and Anglia Ruskin University, is reported in the Journal of Cachexia, Sarcopenia and Muscle.
With liquid biopsies, detecting cancer and tracking treatment progress can be as easy as taking a blood test. This is an increasingly popular way of monitoring cancer, because it’s much less invasive than solid tumour biopsies. And liquid biopsies can become even more sensitive if they capture methylation information as well as genetic data.
Usually, liquid biopsies for cancer rely on the detection of small amounts of DNA that are shed from a tumour into the bloodstream. But especially in the disease’s early stages, circulating tumour DNA (ctDNA) levels are very low and point mutations linked to cancer can be easy to miss.
“If we want to develop assays to detect cancer earlier, we need very sensitive detection of these rare tumour fragments,” says Charlotte Proudhon, group leader at the Research Institute for Environmental and Occupational Health in Rennes, France, whose team are among those now developing liquid biopsy methods that include epigenetic markers, such as methylation.
A new University of Maryland-led discovery could spur the development of new and improved treatments for Hutchinson-Gilford progeria syndrome (HGPS), often simply called “progeria”—a rare genetic disorder with no known cure that causes accelerated aging in children.
Publishing in the journal Aging…
Researchers identify protein that could improve cardiovascular health of those with progeria.
Organic electrochemical transistors (OECTs) are neuromorphic transistors made of carbon-based materials that combine both electronic and ionic charge carriers. These transistors could be particularly effective solutions for amplifying and switching electronic signals in devices designed to be placed on the human skin, such as smart watches, trackers that monitor physiological signals and other wearable technologies.
In contrast with conventional neuromorphic transistors, OECTs could operate reliably in wet or humid environments, which would be highly advantageous for both medical and wearable devices. Despite their potential, most existing OECTs are based on stiff materials, which can reduce the comfort of wearables and thus hinder their large-scale deployment.
Researchers at the University of Hong Kong have developed a new wearable device based on stretchable OECTs that can both perform computations and collect signals from the surrounding environment. Their proposed system, presented in a paper published in Nature Electronics, could be used to realize in-sensor edge computing on a flexible wearable device that is comfortable for users.
A recent study from the University of California San Diego School of Medicine, investigating meditation as a treatment for chronic lower back pain, has revealed that men and women use different biological mechanisms for pain relief. Men primarily rely on the release of endogenous opioids, the body’s natural painkillers, whereas women depend on alternative, non-opioid pathways to manage pain.
Synthetic opioid drugs, such as morphine and fentanyl, are the most powerful class of painkilling drugs available. Women are known to respond poorly to opioid therapies, which use synthetic opioid molecules to bind to the same receptors as naturally occurring endogenous opioids. This aspect of opioid drugs helps explain why they are so powerful as painkillers, but also why they carry a significant risk of dependence and addiction.
“Dependence develops because people start taking more opioids when their original dosage stops working,” said Fadel Zeidan, Ph.D., professor of anesthesiology and Endowed Professor in Empathy and Compassion Research at UC San Diego Sanford Institute for Empathy and Compassion. “Although speculative, our findings suggest that maybe one reason that females are more likely to become addicted to opioids is that they’re biologically less responsive to them and need to take more to experience any pain relief.”