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Nasal nanomedicine delivers immune-boosting therapy to fight brain tumors

Researchers at Washington University School of Medicine in St. Louis, along with collaborators at Northwestern University, have developed a noninvasive approach to treat one of the most aggressive and deadly brain cancers. Their technology uses precisely engineered structures assembled from nano-size materials to deliver potent tumor-fighting medicine to the brain through nasal drops. The novel delivery method is less invasive than similar treatments in development and was shown in mice to effectively treat glioblastoma by boosting the brain’s immune response.

Type 1 Diabetes Cured in Mice Given Experimental Hybrid Treatment

A specially devised hybrid treatment has shown tremendous potential for treating type 1 diabetes in mice, scoring full marks at preventing the condition in prediabetic animals and at reversing the condition in animals with fully developed diabetes.

What makes the new approach stand out is that it successfully combines immune system cells from both the patient mouse and a donor mouse, encouraging them to live in harmony without a need for immunosuppressive drugs for at least four months.

The researchers behind the work, led by a team from the Stanford School of Medicine, are hopeful the same approach could be successful in humans too. The treatment might also have potential for other procedures where transplants are required.

Long-Term Personalized Adaptive Deep Brain Stimulation in Parkinson Disease: A Nonrandomized Clinical Trial

Long-term adaptive deep brain stimulation (aDBS) provided tolerable, effective, and safe therapy in persons with Parkinson disease whose symptoms were previously stable while receiving continuous DBS.


Question Is long-term adaptive deep brain stimulation (aDBS) tolerable and as effective and safe as continuous DBS (cDBS)?

Findings In this nonrandomized clinical trial with an open-label comparison between cDBS and aDBS, the primary outcome was met as the majority of participants receiving aDBS achieved a performance goal of good on-time (ie, time when symptoms were well controlled) without troublesome dyskinesia relative to stable cDBS therapy.

Meaning Long-term aDBS provided tolerable, effective, and safe therapy in persons with Parkinson disease whose symptoms were previously stable while receiving cDBS.

Single-dose radiation before surgery can eradicate breast cancer

A single, targeted high dose of radiation delivered before other treatments could completely eradicate tumors in most women with early-stage, operable hormone-positive breast cancer, according to a study led by UT Southwestern Medical Center researchers. The findings, published in JAMA Network Open, could shift the paradigm for patients with the most common form of breast cancer, who typically undergo surgery before a regimen of radiation therapy.

“This is a major advance in the field,” said study leader Asal Rahimi, M.D., Professor of Radiation Oncology, Associate Vice Chair for Program Development, and Medical Director of the Clinical Research Office at the Harold C. Simmons Comprehensive Cancer Center. “This provides patients a significant time savings, spares a lot of their tissue from irradiation, and allows them to still undergo any type of oncoplastic surgery they may choose, all while very effectively treating their disease.”

Peace lily: why leaves turn brown and how to fix it, according to experts

It’s not random.

The Spathiphyllum is forgiving, but it signals stress fast. Brown patches and crunchy tips are a nudge from the plant about its air, water, or light. Here’s how specialists diagnose those signals and the small adjustments that bring foliage back to lush green.

Brown on a peace lily is usually a care mismatch, not a fatal disease. The plant is reacting to dry air, irregular watering, hard tap water, or harsh sun. Each cause marks leaves a little differently, which helps you zero in on the fix.

How T cells transform to defend our organs

We owe a lot to tissue resident memory T cells (TRM). These specialized immune cells are among the body’s first responders to disease.

Rather than coursing through the bloodstream—as many T cells do—our TRM cells specialize in defending specific organs. They battle viruses, , , melanomas, and many other health threats.

Pandurangan Vijayanand, M.D., Ph.D., William K. Bowes Distinguished Professor at La Jolla Institute for Immunology (LJI), has even shown that a greater density of TRM cells is linked to better survival outcomes in lung cancer patients.

Pro-inflammatory diets linked to accelerated brain aging in older adults

The study also utilized blood samples collected at the beginning of the research period. The investigators measured several biomarkers of systemic inflammation, including C-reactive protein and white blood cell counts. These markers were combined into a composite inflammation score. This score allowed the team to test if inflammation in the body explained the link between diet and brain changes.

The results revealed a significant association between dietary habits and brain aging. Individuals who consumed the most pro-inflammatory diets had a larger brain age gap compared to those who ate anti-inflammatory diets. Specifically, those in the most pro-inflammatory group had brains that appeared about half a year older on average than those in the healthiest diet group. This suggests that poor dietary quality may accelerate the biological clock of the brain.

This association was dependent on the age of the participants. The link between a pro-inflammatory diet and older brain age was much stronger in adults aged 60 and older. In this older demographic, a pro-inflammatory diet was associated with an advanced brain age of nearly a full year. This implies that older adults might be more vulnerable to the negative effects of a poor diet.

The Waist-To-Hip RatioModifies LP(a)-Associated CVD Risk

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