Lifeboat Foundation

This is a new channel with Liz Parrish. This is an hour with Aubrey.

Most people consider #aging to be a normal part of the cycle of #life and #death. But, did you know that some people see aging merely as a disease?
Which means that they believe there is a cure for aging.
And, these people are in pursuit of that cure.

Continue reading “Ep#04 Aubrey De Grey : What if we don’t have to die” »

With the Monsoon rains comes many infectious diseases that can pose health risks, such as mosquito-borne malaria and dengue.

Early suggestion for a likely diagnosis can save lives. However, many infections share the same symptoms and clinical findings. The combination of a detailed patient anamnesis, physical examination, and laboratory data is therefore a prerequisite for identification of the likely cause.

In a paper published in Science Advances, an international team led by deCODE genetics, a subsidiary of Amgen, reveals the discovery of sequence variants in the gene ABCC9 that influence the pitch of voices.

Speaking is one of the most characteristic human behaviors, and yet the genetic underpinnings of voice and speech are largely unknown. In the first study of its kind, the scientists combined speech recordings from almost 13,000 Icelanders with data, in the sequence of the genome, to search for common variants in ABCC9 that are associated with a higher-pitched voice.

Continue reading “Study reveals first genetic locus for voice pitch” »

Prostate cancer is the most common non-skin cancer in men worldwide. According to international estimates about one in six men will get prostate cancer during their lifetime and worldwide, over 375,000 patients will die from it each year. Tumor resistance to current therapies plays an essential role in this and new approaches are therefore urgently needed.

Now an international research team from the University of Bern, Inselspital Bern and the University of Connecticut has identified a previously unknown weak spot in prostate cancer cells. This weak spot is possibly also present in other cancer cells. The study was led by Mark Rubin from the Department for Biomedical Research (DBMR) and Center for Precision Medicine (BCPM) at the University of Bern and Inselspital Bern, and Rahul Kanadia from the Department of Physiology and Neurobiology and the Institute for Systems Genomics at the University of Connecticut. The research results have been published in the journal Molecular Cell.

“We took a closer look at a certain molecular machine called the spliceosome,” explains Anke Augspach, lead author of the study and researcher from the Department for BioMedical Research (DBMR). “It plays an important role in the translation of genes into proteins. In this process, the spliceosome separates parts of the gene that are not needed for the production of the protein and fuses the other parts.”

Researchers have observed spontaneous reversal of the devastating heart condition transthyretin cardiac amyloidopathy for the first time, edging closer to a cure.

An international research team has succeeded for the first time in measuring the electron spin in matter—i.e., the curvature of space in which electrons live and move—within “kagome materials,” a new class of quantum materials.

The results obtained—published in Nature Physics —could revolutionize the way quantum materials are studied in the future, opening the door to new developments in quantum technologies, with possible applications in a variety of technological fields, from renewable energy to biomedicine, from electronics to quantum computers.

Success was achieved by an international collaboration of scientists, in which Domenico Di Sante, professor at the Department of Physics and Astronomy “Augusto Righi,” participated for the University of Bologna as part of his Marie Curie BITMAP research project. He was joined by colleagues from CNR-IOM Trieste, Ca’ Foscari University of Venice, University of Milan, University of Würzburg (Germany), University of St. Andrews (UK), Boston College and University of Santa Barbara (U.S.).

Visits with a 24/7, co-payment-free telemedicine program established by Penn Medicine for its employees were 23% less expensive than in-person visits for the same conditions, according to a new analysis published in the American Journal of Managed Care.

Researchers at the Perelman School of Medicine at the University of Pennsylvania found that the per-visit costs for the telemedicine program, called Penn Medicine OnDemand, averaged $380 while in-person encounters in primary care offices, emergency departments, or urgent care clinics during the same timeframe cost $493 to conduct, a $113 difference per patient.

“The conditions most often handled by OnDemand are low acuity—non-urgent or semi-urgent issues like respiratory infections, sinus infections, and allergies—but incredibly common, so any kind of cost reduction can make a huge difference for controlling employee benefit costs,” said the study’s lead researcher, Krisda Chaiyachati, MD, an adjunct assistant professor of Medicine at Penn Medicine, who previously served as medical director of Penn Medicine OnDemand and now is the physician lead for Value-based Care and Innovation at Verily. “This research shows the clear financial benefits when hospitals and health systems offer telemedicine services directly to their own employees.”

Chemical signals from contracting muscles can influence the growth of brain networks, according to new research published in Neuroscience. The study highlights the importance of physical activity to mental health, and the findings could also help contribute to the development of more effective treatments for cognitive disorders such as Alzheimer’s disease.

Previous studies had shown that exercise has significant benefits for cognitive health, even when initiated at late stages in life. Exercise has been associated with long-term changes in the hippocampus, a brain region crucial for learning and memory, including increased neurogenesis, synaptogenesis, and enlarged volume.

However, the specific mechanisms through which exercise produces these changes in the hippocampus were not well understood. By uncovering these mechanisms, the authors behind the new study aim to develop exercise-based treatments for cognitive pathologies that affect the hippocampus, such as Alzheimer’s disease, stress, depression, anxiety, and normal aging.

Almost as soon as there were super-resolution microscopes, scientists pointed them towards molecular motors called kinesins. These proteins, powered by the molecular fuel ATP, drive crucial processes including cell division, cell signalling and intracellular transport by shuttling cargo along protein highways called microtubules. Researchers have long wanted to understand how these motors work, but to visualize them, scientists have had to slow them down or isolate them in simplified, in vitro systems.

Now, in papers published concurrently in Science, two teams working independently have used a super-resolution tool called MINFLUX to study the motor in near-real time at physiologically relevant concentrations of ATP. The first paper, led by MINFLUX’s inventor, Stefan Hell, who has a joint appointment at the Max Planck Institute (MPI) for Multidisciplinary Sciences in Göttingen and the MPI for Medical Research in Heidelberg, both in Germany, used a new instrument design to track the protein in 3D, revealing details about its motion¹. The second, led by biophysicist Jonas Ries at the European Molecular Biology Laboratory in Heidelberg, showed for the first time that MINFLUX is capable of tracking kinesin even amid the bustle of living cells².

“This technology requires a lot of different things to work, and it’s fun to see all of these things coming together,” says Michelle Digman, a biomedical engineer at the University of California, Irvine, who develops imaging strategies but was not involved in either study. “It seemed like a proof of concept to show that they’re able to track kinesin very precisely. And when you have the live cell system, that’s even more spectacular.”