Lifeboat Foundation

Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. In people with healthy bones, new bone is always replacing old bone. In osteonecrosis, the lack of blood causes the bone to break down faster than the body can make enough new bone. The bone starts to die and may break down.

You can have osteonecrosis in one or several bones. It is most common in the upper leg. Other common sites are your upper arm and your knees, shoulders and ankles. The disease can affect men and women of any age, but it usually strikes in your thirties, forties or fifties.

At first, you might not have any symptoms. As the disease gets worse, you will probably have joint pain that becomes more severe. You may not be able to bend or move the affected joint very well.

The Covid Moonshot effort to develop antivirals began in 2020 with a tweet. Three and a half years later, the team has a leading drug candidate.

Treating mental disorders with fewer side effects

Now, researchers have managed to genetically modify yeast cells to produce drugs for mental disorders such as schizophrenia with fewer side effects.

“Development of medicines from natural plant substances is widely used. However, since plants do not produce these substances to fight human diseases, there is often a need to modify them to make them more effective and safe,” said Michael Krogh Jensen, a senior researcher at DTU Biosustain and co-founder of the biotech company Biomia.

The challenge of measuring adult neurogenesis is difficult, but it’s not impossible. A big part of the solution is knowing what to measure and where. While this new study was performed on rats—and therefore may be a poor predictor of what we’ll see in humans—it can direct future research by showing neuroscientists where to look and what to look for.

And unlike the hard problem of consciousness, unraveling the mysteries of adult neurogenesis may have clinical applications. Better the lifecycle of neurons may reveal how neurological disorders such as Parkinson’s and Alzheimer’s disease emerge. There’s even research linking disorders such as depression and anxiety to neurogenesis activity.

Continue reading “Adult-made neurons mature longer, have unique functions” »

Only 2% of Alzheimer’s is 100% genetic. The rest is up to your daily habits.

Up Next ► 4 ways to hack your memory https://youtu.be/SCsztDMGP7o.

Continue reading “5 ways to build an Alzheimer’s-resistant brain | Lisa Genova” »

A team of surgeons in New York has performed the world’s first transplant of an entire eye in a procedure widely hailed as a medical breakthrough, although it isn’t yet known whether the man will ever see through the donated eye.

The groundbreaking surgery involved removing part of the face and the whole left eye—including its blood supply and optic nerve—of a donor and grafting them onto a lineworker from Arkansas who survived a 7,200-volt electric shock in June 2021.

Aaron James, 46, suffered extensive injuries including the loss of his left eye, his dominant left arm above the elbow, his nose and lips, front teeth, left cheek area and chin.

Researchers at the University of Oxford, UK have found that butyrate, a short-chain fatty acid produced by gut bacteria, can boost the antimicrobial activity of immune cells in the gut, possibly helping them better fend off bacterial infections and improve immune health.

The study, which exposed human monocytes and macrophages (immune cells) to bacterial infections to simulate real-world scenarios in the lab, backs up ongoing research into the benefits of butyrate as a therapeutic component to combat conditions—from food allergies to inflammatory bowel disease (IBD) and support immune system function.

CAR T treatments help revolutionize treatment of blood cancer. Now, researchers are engineering immune cells to take aim at solid tumors.

It quadrupled the rate at which doctors talked to patients about their.

An AI that encourages doctors to talk to cancer patients about their end-of-life care impacts how they choose to live out their final days.